Lung γδ T Cells Mediate Protective Responses during Neonatal Influenza Infection that Are Associated with Type 2 Immunity

Influenza infection causes mortality in infants and protective immunity in this population is poorly understood. Guo et al. find that γδ T cells are required for recovery after neonatal influenza infection. γδ T cell-derived IL-17A is associated with the tissue repair response orchestrated by IL-33, ILC2s, and amphiregulin, and IL-17A correlates with improved disease outcomes in influenza-infected children.

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