A simple, safe, targeted and efficient in vivo DNA delivery system is necessary for clinical-grade liver targeted gene therapy in humans. Intravascular hydrodynamic gene delivery has been investigated in large animal models but translation to humans has been hampered by its technical challenges, invasiveness and potential for significant cardiovascular adverse events. We posited that intrabiliary delivery of DNA plasmids via ERCP-guided hydrodynamic injection overcomes these obstacles.
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Τρίτη 3 Ιουλίου 2018
Successful liver-directed gene delivery by ERCP-guided hydrodynamic injection (with videos)
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Αλέξανδρος Γ. Σφακιανάκης Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,0030693260717...
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Alimentary Pharmacology &Therapeutics, EarlyView. https://ift.tt/2qECBIJ
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heory of COVID-19 pathogenesis Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Yuichiro J. Suzuki ScienceD...
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