Neuropilin-1 (NRP-1) upregulated by IL-6/STAT3 signalling contributes to invasion in pancreatic neuroendocrine neoplasms

Although the upregulation of Neuropilin-1 (NRP-1) is associated with many solid tumours, its role in pancreatic neuroendocrine neoplasms (pNEN) has not been well elucidated. The aim of this study was to investigate the role of NRP-1 in improving treatment and determining the prognosis of pNEN. In this study, the expression of NRP-1 in pNEN tissue samples and pNEN cell line BON1 was analysed by Western blot, polymerase chain reaction (PCR) and immunocytochemistry upon exposure to interleukin-6 (IL-6).

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