Phosphatidylinositol-3-kinase mutations are associated with increased local failure in brain metastases treated with radiation

We retrospectively reviewed 259 patients with brain metastases treated with whole brain radiation (WBRT) or stereotactic radiosurgery (SRS). Patients with PIK3 mutations were found to be at higher risk for LF following WBRT, while PIK3 mutations were not significantly associated with LF following SRS. Novel therapeutic strategies to improve outcomes in patients with PIK3 mutations undergoing WBRT should be considered.

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