Genomics Reloaded: Rise of the Expression Profiles

In this issue of Oncology Scan, similar to previous head and neck cancer Oncology Scans (1-7), we examine the use of genomic signatures to predict response to head and neck cancer therapy (8-10). In the past decade and a half, multiple teams have identified and developed gene expression profile signatures capable of subclassifying head and neck cancer, prognosticating outcome, and predicting treatment response. We discuss the implications of these genomic signatures for head and neck cancer patients, how these signatures can be applied to other therapies, their use to assist in preclinical studies, and suggestions on how this work can move the field forward, not just for head and neck cancer but potentially for all types of cancers.

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