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Δευτέρα 8 Μαΐου 2017

Blood Pressure Variability: Does it Predict the Outcome of Acute Ischemic Stroke?

<span class="paragraphSection">Stroke is a leading cause of death and disability worldwide.<sup><a href="#CIT0001" class="reflinks">1</a></sup> The prognosis of stroke is highly variable and a large number of studies aimed to identify predictors of outcome in these patients in order to guide treatment decisions.<sup><a href="#CIT0002" class="reflinks">2</a></sup> Elevated blood pressure (BP) during the acute phase of stroke was an independent predictor of adverse outcome in some reports<sup><a href="#CIT0003" class="reflinks">3</a>,<a href="#CIT0004" class="reflinks">4</a></sup> but others did not confirm this association.<sup><a href="#CIT0005" class="reflinks">5</a>,<a href="#CIT0006" class="reflinks">6</a></sup> More recently, focus has shifted to BP variability as a risk factor for cardiovascular morbidity and mortality.<sup><a href="#CIT0007" class="reflinks">7–9</a></sup> In hypertensive patients and normotensive subjects, increased BP variability appears to increase the risk of cardiovascular events and all-cause mortality independently of clinic or ambulatory BP measurements.<sup><a href="#CIT0007" class="reflinks">7–9</a></sup> However, there are limited and conflicting data regarding the prognostic significance of BP variability during the acute phase of ischemic stroke.<sup><a href="#CIT0005" class="reflinks">5</a>,<a href="#CIT0010" class="reflinks">10</a></sup></span>

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