Ocular oncology: advances in retinoblastoma, uveal melanoma and conjunctival melanoma

<span class="paragraphSection"><div class="boxTitle">Abstract</div><div class="boxTitle">Background</div>Retinoblastoma, uveal and conjunctival melanomas are important malignancies within the remit of ocular oncology. Outlined are the diagnostic features and management principles, as well as advancements in the field and current challenges.<div class="boxTitle">Sources of data</div>Original papers, reviews and guidelines.<div class="boxTitle">Areas of agreement</div>Most eyes with retinoblastoma (International Intraocular Retinoblastoma Classification (IIRC) Group A–D) are salvaged, whereas advanced cases (Group E) remain a challenge. Despite a high rate of local tumour control in uveal melanoma, metastatic spread commonly occurs. Conjunctival melanoma is treated by complete resection, but high rates of local recurrence occur, with the possibility of systemic relapse and death.<div class="boxTitle">Areas of controversy</div>Use of the IIRC in retinoblastoma, and systemic screening in melanomas.<div class="boxTitle">Growing points</div>Utilization of novel treatment modalities in retinoblastoma and an increasing understanding of the genetic basis of melanomas.<div class="boxTitle">Areas timely for developing research</div>Improvements in chemotherapy delivery in retinoblastoma and prognostic tests in melanomas.</span>

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