Publication date: Available online 23 January 2016
Source:Cortex
Author(s): Valerie C. Brandt, Christian Beck, Valeria Sajin, Magdalena K. Baaske, Tobias Bäumer, Christian Beste, Silke Anders, Alexander Münchau
Premonitory urges are a cardinal feature in Tourette syndrome and are commonly viewed as the driving force of tics, building up before and subsiding after the execution of tics. Although the urge-tic interplay is one of the most preeminent features in Tourette syndrome, the temporal relationship between tics and urges has never been examined experimentally, mainly due to the lack of an appropriate assessment tool.We investigated the temporal relationship between urge intensity and tics in 17 Tourette patients and between urge intensity and eye blinks in 16 healthy controls in a free ticcing/blinking condition and a tic/blink suppression condition. For this purpose, an urge assessment tool was developed that allows real-time monitoring and quantification of urge intensity.Compared to free ticcing/blinking, urge intensity was higher during the suppression condition in both Tourette patients and healthy controls, while tics and blinks occurred less frequently.The data show that urge intensity increases prior to tics and decreases after tics in a time window of approximately ±10 seconds. Tic suppression had a significant effect on the shape of the urge distribution around tics and led to a decrease in the size of the correlation between urge intensity and tics, indicating that tic suppression led to a de-coupling of tics and urges.In healthy controls, urges to blink were highly associated with eye blink execution, albeit in a narrower time frame (∼±5 seconds). Blink suppression had a similar effect on the urge distribution associated with eye blinks as tic suppression had on the urge to tic in Tourette patients.These results corroborate the negative reinforcement model, which proposes that tics are associated with a relief in urges, thereby perpetuating ticcing behaviour. This study also documents similarities and differences between urges to act in healthy controls and urges to tic in Tourette syndrome.
from #Medicine via ola Kala on Inoreader http://ift.tt/1UiNfLt
via IFTTT
Αρχειοθήκη ιστολογίου
-
►
2023
(138)
- ► Φεβρουαρίου (74)
- ► Ιανουαρίου (64)
-
►
2022
(849)
- ► Δεκεμβρίου (61)
- ► Σεπτεμβρίου (74)
- ► Φεβρουαρίου (65)
-
►
2021
(2936)
- ► Δεκεμβρίου (59)
- ► Σεπτεμβρίου (180)
- ► Φεβρουαρίου (325)
-
►
2020
(1624)
- ► Δεκεμβρίου (293)
- ► Σεπτεμβρίου (234)
- ► Φεβρουαρίου (28)
-
►
2019
(13362)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (5586)
- ► Ιανουαρίου (5696)
-
►
2018
(66471)
- ► Δεκεμβρίου (5242)
- ► Σεπτεμβρίου (5478)
- ► Φεβρουαρίου (4835)
- ► Ιανουαρίου (5592)
-
►
2017
(44259)
- ► Δεκεμβρίου (5110)
- ► Σεπτεμβρίου (5105)
-
▼
2016
(7467)
- ► Δεκεμβρίου (514)
- ► Σεπτεμβρίου (1038)
- ► Φεβρουαρίου (793)
-
▼
Ιανουαρίου
(578)
-
▼
Ιαν 23
(50)
- A Sentimentalist Theory of Mind, by Michael Slote.
- Apical Resection Mouse Model to Study Early Mammal...
- A Novel Microsurgical Model for Heterotopic, En Bl...
- Longitudinal Associations of Friend-Based Social S...
- Implication of Immunokine Profiling for Cancer Sta...
- Systemic activation of the immune system in HIV in...
- Hypothesis: A single dose of an anxiolitic may pre...
- Insulin resistance is a two-sided mechanism acting...
- The low-frequency (delta and theta) oscillations m...
- Great expectations: Nutritional medicine as a main...
- ICF - Measure of Participation and Activities Scre...
- Medical Outcomes Short-Form Health Survey
- Vestibular Rehabilitation Benefits Questionnaire
- Vestibular Activities and Participation Measure
- Vestibular Disorders Activities of Daily Living Scale
- University of California Los Angeles Dizziness Que...
- Supine to Stand Test
- Unified Dyskinesia Rating Scale
- Rivermead Mobility Index
- Medical Outcomes Study Short Form 36
- A physiological signature of sound meaning in deme...
- Temporal relationship between premonitory urges an...
- Getting lost: Topographic skills in acquired and d...
- Age-related differences of neural connectivity dur...
- The Effects of a Novel Therapeutic Intervention in...
- A Randomized Controlled Trial of a Home-Based Acti...
- The effect of early intensive care on recovery fro...
- Plasmatic proinflammatory chemokines levels are tr...
- DDAH1 deficiency promotes intracellular oxidative ...
- “Cold training” affects rat liver responses to con...
- Interaction between left ventricular twist mechani...
- Effects of postoperative administration of celecox...
- Neurophysiological Markers of Multiple Facets of I...
- Corrigendum to “Reduced intrasubject variability w...
- Remote Sensing, Vol. 8, Pages 86: Characterization...
- IJERPH, Vol. 13, Pages 157: Associations of Age, B...
- The effect of age and unilateral leg immobilizatio...
- Influence of exercise intensity and duration on fu...
- Physiological and pathophysiological ROS as probed...
- Remote Sensing, Vol. 8, Pages 91: Treating the Hoo...
- IJMS, Vol. 17, Pages 149: Cissus sicyoides: Pharma...
- The Yeast ATF1 Acetyltransferase Efficiently Acety...
- Remote Sensing, Vol. 8, Pages 90: Validation and S...
- Remote Sensing, Vol. 8, Pages 89: Multi-View Stere...
- Molecules, Vol. 21, Pages 138: Antioxidant Activit...
- Sensors, Vol. 16, Pages 146: An Adaptive INS-Aided...
- IJERPH, Vol. 13, Pages 155: Association between Ps...
- Healthcare, Vol. 4, Pages 13: Musculoskeletal Diso...
- Land, Vol. 5, Pages 2: Acknowledgement to Reviewer...
- IJMS, Vol. 17, Pages 149: Cissus sicyoides: Pharma...
-
▼
Ιαν 23
(50)
Αναζήτηση αυτού του ιστολογίου
Σάββατο 23 Ιανουαρίου 2016
Temporal relationship between premonitory urges and tics in Gilles de la Tourette syndrome
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
-
Αλέξανδρος Γ. Σφακιανάκης Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,0030693260717...
-
heory of COVID-19 pathogenesis Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Yuichiro J. Suzuki ScienceD...
-
Alimentary Pharmacology &Therapeutics, EarlyView. https://ift.tt/2qECBIJ
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου
Σημείωση: Μόνο ένα μέλος αυτού του ιστολογίου μπορεί να αναρτήσει σχόλιο.