The objective of this study was to evaluate the pharmacological mechanisms involved in anti-inflammatory and antidiarrheal actions of hydroalcoholic extract obtained from the leaves of Cissus sicyoides (HECS). The anti-inflammatory effect was evaluated by oral administration of HECS against acute model of edema induced by xylene, and the mechanisms of action were analysed by involvement of arachidonic acid (AA) and prostaglandin E2 (PGE2). The antidiarrheal effect of HECS was observed and we analyzed the motility and accumulation of intestinal fluid. We also analyzed the antidiarrheal mechanisms of action of HECS by evaluating the role of the opioid receptor, α2 adrenergic receptor, muscarinic receptor, nitric oxide (NO) and PGE2. The oral administration of HECS inhibited the edema induced by xylene and AA and was also able to significantly decrease the levels of PGE2. The extract also exhibited significant anti-diarrheal activity by reducing motility and intestinal fluid accumulation. This extract significantly reduced intestinal transit stimulated by muscarinic agonist and intestinal secretion induced by PGE2. Our data demonstrate that the mechanism of action involved in the anti-inflammatory effect of HECS is related to PGE2. The antidiarrheal effect of this extract may be mediated by inhibition of contraction by acting on the intestinal smooth muscle and/or intestinal transit.
from #Medicine via ola Kala on Inoreader http://ift.tt/1Ui2oN3
via IFTTT
Αρχειοθήκη ιστολογίου
-
►
2023
(138)
- ► Φεβρουαρίου (74)
- ► Ιανουαρίου (64)
-
►
2022
(849)
- ► Δεκεμβρίου (61)
- ► Σεπτεμβρίου (74)
- ► Φεβρουαρίου (65)
-
►
2021
(2936)
- ► Δεκεμβρίου (59)
- ► Σεπτεμβρίου (180)
- ► Φεβρουαρίου (325)
-
►
2020
(1624)
- ► Δεκεμβρίου (293)
- ► Σεπτεμβρίου (234)
- ► Φεβρουαρίου (28)
-
►
2019
(13362)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (5586)
- ► Ιανουαρίου (5696)
-
►
2018
(66471)
- ► Δεκεμβρίου (5242)
- ► Σεπτεμβρίου (5478)
- ► Φεβρουαρίου (4835)
- ► Ιανουαρίου (5592)
-
►
2017
(44259)
- ► Δεκεμβρίου (5110)
- ► Σεπτεμβρίου (5105)
-
▼
2016
(7467)
- ► Δεκεμβρίου (514)
- ► Σεπτεμβρίου (1038)
- ► Φεβρουαρίου (793)
-
▼
Ιανουαρίου
(578)
-
▼
Ιαν 23
(50)
- A Sentimentalist Theory of Mind, by Michael Slote.
- Apical Resection Mouse Model to Study Early Mammal...
- A Novel Microsurgical Model for Heterotopic, En Bl...
- Longitudinal Associations of Friend-Based Social S...
- Implication of Immunokine Profiling for Cancer Sta...
- Systemic activation of the immune system in HIV in...
- Hypothesis: A single dose of an anxiolitic may pre...
- Insulin resistance is a two-sided mechanism acting...
- The low-frequency (delta and theta) oscillations m...
- Great expectations: Nutritional medicine as a main...
- ICF - Measure of Participation and Activities Scre...
- Medical Outcomes Short-Form Health Survey
- Vestibular Rehabilitation Benefits Questionnaire
- Vestibular Activities and Participation Measure
- Vestibular Disorders Activities of Daily Living Scale
- University of California Los Angeles Dizziness Que...
- Supine to Stand Test
- Unified Dyskinesia Rating Scale
- Rivermead Mobility Index
- Medical Outcomes Study Short Form 36
- A physiological signature of sound meaning in deme...
- Temporal relationship between premonitory urges an...
- Getting lost: Topographic skills in acquired and d...
- Age-related differences of neural connectivity dur...
- The Effects of a Novel Therapeutic Intervention in...
- A Randomized Controlled Trial of a Home-Based Acti...
- The effect of early intensive care on recovery fro...
- Plasmatic proinflammatory chemokines levels are tr...
- DDAH1 deficiency promotes intracellular oxidative ...
- “Cold training” affects rat liver responses to con...
- Interaction between left ventricular twist mechani...
- Effects of postoperative administration of celecox...
- Neurophysiological Markers of Multiple Facets of I...
- Corrigendum to “Reduced intrasubject variability w...
- Remote Sensing, Vol. 8, Pages 86: Characterization...
- IJERPH, Vol. 13, Pages 157: Associations of Age, B...
- The effect of age and unilateral leg immobilizatio...
- Influence of exercise intensity and duration on fu...
- Physiological and pathophysiological ROS as probed...
- Remote Sensing, Vol. 8, Pages 91: Treating the Hoo...
- IJMS, Vol. 17, Pages 149: Cissus sicyoides: Pharma...
- The Yeast ATF1 Acetyltransferase Efficiently Acety...
- Remote Sensing, Vol. 8, Pages 90: Validation and S...
- Remote Sensing, Vol. 8, Pages 89: Multi-View Stere...
- Molecules, Vol. 21, Pages 138: Antioxidant Activit...
- Sensors, Vol. 16, Pages 146: An Adaptive INS-Aided...
- IJERPH, Vol. 13, Pages 155: Association between Ps...
- Healthcare, Vol. 4, Pages 13: Musculoskeletal Diso...
- Land, Vol. 5, Pages 2: Acknowledgement to Reviewer...
- IJMS, Vol. 17, Pages 149: Cissus sicyoides: Pharma...
-
▼
Ιαν 23
(50)
Αναζήτηση αυτού του ιστολογίου
Σάββατο 23 Ιανουαρίου 2016
IJMS, Vol. 17, Pages 149: Cissus sicyoides: Pharmacological Mechanisms Involved in the Anti-Inflammatory and Antidiarrheal Activities
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
-
Αλέξανδρος Γ. Σφακιανάκης Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,0030693260717...
-
heory of COVID-19 pathogenesis Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Yuichiro J. Suzuki ScienceD...
-
Alimentary Pharmacology &Therapeutics, EarlyView. https://ift.tt/2qECBIJ
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου
Σημείωση: Μόνο ένα μέλος αυτού του ιστολογίου μπορεί να αναρτήσει σχόλιο.