Publication date: Available online 23 January 2016
Source:Medical Hypotheses
Author(s): Larisa B. Korolevskaya, Konstantin V. Shmagel, Nadezhda G. Shmagel, Evgeniya V. Saidakova
Currently, immune activation is proven to be the basis for the HIV infection pathogenesis and a strong predictor of the disease progression. Among the causes of systemic immune activation the virus and its products, related infectious agents, pro-inflammatory cytokines, and regulatory CD4+ T cells' decrease are considered. Recently microbial translocation (bacterial products yield into the bloodstream as a result of the gastrointestinal tract mucosal barrier integrity damage) became the most popular hypothesis. Previously, we have found an association between immune complexes present in the bloodstream of HIV infected patients and the T cell activation. On this basis, we propose a significantly modified hypothesis of immune activation in HIV infection. It is based on the immune complexes' participation in the immunocompetent cells' activation. Immune complexes are continuously formed in the chronic phase of the infection. Together with TLR-ligands (viral antigens, bacterial products coming from the damaged gut) present in the bloodstream they interact with macrophages. As a result macrophages are transformed into the type II activated forms. These macrophages block IL-12 production and start synthesizing IL-10. High level of this cytokine slows down the development of the full-scale Th1-response. The anti-viral reactions are shifted towards the serogenesis. Newly synthesized antibodies' binding to viral antigens leads to continuous formation of the immune complexes capable of interacting with antigen-presenting cells.
from #Medicine via ola Kala on Inoreader http://ift.tt/1OFkB5K
via IFTTT
Αρχειοθήκη ιστολογίου
-
►
2023
(138)
- ► Φεβρουαρίου (74)
- ► Ιανουαρίου (64)
-
►
2022
(849)
- ► Δεκεμβρίου (61)
- ► Σεπτεμβρίου (74)
- ► Φεβρουαρίου (65)
-
►
2021
(2936)
- ► Δεκεμβρίου (59)
- ► Σεπτεμβρίου (180)
- ► Φεβρουαρίου (325)
-
►
2020
(1624)
- ► Δεκεμβρίου (293)
- ► Σεπτεμβρίου (234)
- ► Φεβρουαρίου (28)
-
►
2019
(13362)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (5586)
- ► Ιανουαρίου (5696)
-
►
2018
(66471)
- ► Δεκεμβρίου (5242)
- ► Σεπτεμβρίου (5478)
- ► Φεβρουαρίου (4835)
- ► Ιανουαρίου (5592)
-
►
2017
(44259)
- ► Δεκεμβρίου (5110)
- ► Σεπτεμβρίου (5105)
-
▼
2016
(7467)
- ► Δεκεμβρίου (514)
- ► Σεπτεμβρίου (1038)
- ► Φεβρουαρίου (793)
-
▼
Ιανουαρίου
(578)
-
▼
Ιαν 23
(50)
- A Sentimentalist Theory of Mind, by Michael Slote.
- Apical Resection Mouse Model to Study Early Mammal...
- A Novel Microsurgical Model for Heterotopic, En Bl...
- Longitudinal Associations of Friend-Based Social S...
- Implication of Immunokine Profiling for Cancer Sta...
- Systemic activation of the immune system in HIV in...
- Hypothesis: A single dose of an anxiolitic may pre...
- Insulin resistance is a two-sided mechanism acting...
- The low-frequency (delta and theta) oscillations m...
- Great expectations: Nutritional medicine as a main...
- ICF - Measure of Participation and Activities Scre...
- Medical Outcomes Short-Form Health Survey
- Vestibular Rehabilitation Benefits Questionnaire
- Vestibular Activities and Participation Measure
- Vestibular Disorders Activities of Daily Living Scale
- University of California Los Angeles Dizziness Que...
- Supine to Stand Test
- Unified Dyskinesia Rating Scale
- Rivermead Mobility Index
- Medical Outcomes Study Short Form 36
- A physiological signature of sound meaning in deme...
- Temporal relationship between premonitory urges an...
- Getting lost: Topographic skills in acquired and d...
- Age-related differences of neural connectivity dur...
- The Effects of a Novel Therapeutic Intervention in...
- A Randomized Controlled Trial of a Home-Based Acti...
- The effect of early intensive care on recovery fro...
- Plasmatic proinflammatory chemokines levels are tr...
- DDAH1 deficiency promotes intracellular oxidative ...
- “Cold training” affects rat liver responses to con...
- Interaction between left ventricular twist mechani...
- Effects of postoperative administration of celecox...
- Neurophysiological Markers of Multiple Facets of I...
- Corrigendum to “Reduced intrasubject variability w...
- Remote Sensing, Vol. 8, Pages 86: Characterization...
- IJERPH, Vol. 13, Pages 157: Associations of Age, B...
- The effect of age and unilateral leg immobilizatio...
- Influence of exercise intensity and duration on fu...
- Physiological and pathophysiological ROS as probed...
- Remote Sensing, Vol. 8, Pages 91: Treating the Hoo...
- IJMS, Vol. 17, Pages 149: Cissus sicyoides: Pharma...
- The Yeast ATF1 Acetyltransferase Efficiently Acety...
- Remote Sensing, Vol. 8, Pages 90: Validation and S...
- Remote Sensing, Vol. 8, Pages 89: Multi-View Stere...
- Molecules, Vol. 21, Pages 138: Antioxidant Activit...
- Sensors, Vol. 16, Pages 146: An Adaptive INS-Aided...
- IJERPH, Vol. 13, Pages 155: Association between Ps...
- Healthcare, Vol. 4, Pages 13: Musculoskeletal Diso...
- Land, Vol. 5, Pages 2: Acknowledgement to Reviewer...
- IJMS, Vol. 17, Pages 149: Cissus sicyoides: Pharma...
-
▼
Ιαν 23
(50)
Αναζήτηση αυτού του ιστολογίου
Σάββατο 23 Ιανουαρίου 2016
Systemic activation of the immune system in HIV infection: the role of the immune complexes (hypothesis)
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
-
Αλέξανδρος Γ. Σφακιανάκης Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,0030693260717...
-
heory of COVID-19 pathogenesis Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Yuichiro J. Suzuki ScienceD...
-
Alimentary Pharmacology &Therapeutics, EarlyView. https://ift.tt/2qECBIJ
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου
Σημείωση: Μόνο ένα μέλος αυτού του ιστολογίου μπορεί να αναρτήσει σχόλιο.