In Reply to Daugherty and Lawrence

Thanks to Daugherty and Lawrence for the thoughtful review and comments1. We agree with your perspective. Margin assessment remains an integral component in evaluating local recurrence risk in patients managed with breast-conserving therapy. We share your concerns that caution is needed, particularly in dealing with patients in whom adjuvant radiation therapy is omitted, including the elderly populations. Clinical trials evaluating outcomes in patients treated without breast radiation therapy require strict adherence to margin clearance.

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