In Reply to Dahele and Verbakel

The authors' letter and translational research work support the question posed in the review1,2: Are we at the tipping point for the era of real-time radiation therapy? The research by Dahele and Verbakel adds additional clinical evidence that real-time 3-dimensional image guided radiation therapy (3D IGRT) can be performed on standard-equipped cancer radiation therapy (RT) systems. Indeed, had it been published or known to us before we wrote the review, their clinical translation of markerless spine tracking3 would have been included as a fourth real-time 3D IGRT implementation on standard-equipped systems.

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