Cancers, Vol. 10, Pages 510: Management of Typical and Atypical Pulmonary Carcinoids Based on Different Established Guidelines

Cancers, Vol. 10, Pages 510: Management of Typical and Atypical Pulmonary Carcinoids Based on Different Established Guidelines

Cancers doi: 10.3390/cancers10120510

Authors: Rohit Gosain Sarbajit Mukherjee Sai S. Yendamuri Renuka Iyer

Neuroendocrine tumors (NETs) are a group of malignancies that originated from neuroendocrine cells, with the most common sites being lungs and the gastrointestinal tract. Lung NETs comprise 25% of all lung malignancies. Small cell lung cancer is the most common form of lung NETs, and other rare forms include well-differentiated typical carcinoids (TCs) and poorly differentiated atypical carcinoids (ACs). Given the paucity of randomized studies, rational treatment is challenging. Therefore, it is recommended that these decisions be made using a multidisciplinary collaborative approach. Surgery remains the mainstay of treatment, when feasible. Following surgery, various guidelines offer different recommendations in the adjuvant setting. In this paper, we describe the adjuvant management of lung NETs, as recommended by different guidelines, and highlight their differences. In addition to that, we also discuss the management of metastatic lung NETS, including the use of peptide receptor radionucleotide therapy.

https://ift.tt/2Lc6qJv