Amphiphilic polysaccharide self‐assembled (SA) nanogels are attractive nanocarriers for biologics owing to their chaperone‐like activity by nanoencapsulating biologics inside their polymer network in the isolated state. This progress report highlights the design and function of SA nanogels, the recent progress in developments of the nanogel‐tectonic materials, and their applications in bone tissue engineering.
Abstract
Amphiphilic polysaccharide self‐assembled (SA) nanogels are promising protein carriers owing to their chaperone‐like activity that allows them to nanoencapsulate proteins within their polymer networks. The chaperoning function is an important concept that has led to breakthroughs in the development of effective protein drug delivery systems by stabilizing formulations and controlling the quality of unstable proteins. Recently, nanogel‐tectonic materials that integrate SA nanogels as building blocks have been designed as new hydrogel biomaterials. This article describes recent progress and applications of SA nanogel tectonic materials as protein delivery systems for tissue engineering.
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