Physical activity effects on the individual alpha peak frequency of older adults with and without genetic risk factors for Alzheimer’s Disease: A MEG study

For more than two decades, an enormous effort has been devoted to the search for pharmacological therapies that could palliate the devastating effects of Alzheimer's Disease (AD). Most of these therapies relied on the so-called "amyloid hypothesis" (Hardy and Higgins, 1992), that is considered the leading explanation for the disease. Unfortunately, clinical trials testing agents that interfere with amyloid production failed to improve cognition or to slow down the deterioration process, while produced substantial side effects (Drachman, 2014; Intlekofer and Cotman, 2013).

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