Modeling in vivo interstitial hydration-pressure relationships in skin and skeletal muscle

A theoretical understanding of hydrostatic pressure- fluid volume relationships, or equations of state, of interstitial fluid in skin and skeletal muscle through mathematical/physical modeling is lacking. Here we investigate at the microscopic level forces that seem to underlie and determine the movements of fluid and solid tissue elements on the microscopic as well as on the macroscopic level. Effects that occur during variation of hydration due to interaction between expanding glycosaminoglycans (GAGs) and the collagen interstitial matrix of tissue seem to be of major importance.

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