Inhibition of Aberrant DNA Re-methylation Improves Post-implantation Development of Somatic Cell Nuclear Transfer Embryos

Gao et al. show that aberrant DNA re-methylation is a critical epigenetic barrier to SCNT embryo development. Inactivation of Dnmts can rescue re-methylation defects and improve post-implantation development of SCNT embryos and overall cloning efficiency, which is further enhanced by simultaneous removal of additional epigenetic barriers.

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