Rates of Osteoporosis Screening and Treatment Following Vertebral Fracture

Publication date: Available online 22 August 2018

Source: The Spine Journal

Author(s): David W Barton, Caleb J Behrend, Jonathan J Carmouche

Structured Abstract

Background Context

Osteoporosis remains an underrecognized and undertreated disease entity in the orthopaedic setting, accounting for substantial long-term morbidity and mortality. Osteoporosis is often not diagnosed or treated until multiple fractures have occurred. Vertebral compression fractures are the most common sentinel fracture, providing an opportunity to intervene with antiresorptive therapy before more debilitating fractures occur. Little data has been published on osteoporosis screening and treatment following vertebral fractures. Further elucidation of the osteoporosis care gap in these patients is warranted.

PURPOSE: To demonstrate the current state of post vertebral fracture osteoporosis management at a large tertiary care center with no established secondary fracture prevention program.

Study Design

Retrospective cohort study

Setting

A large tertiary care hospital or one of its affiliated community hospitals

Patient Sample

All 2933 patients 50 years of age or older who presented to an emergency department with a new vertebral fracture between 2008 and 2014.

Outcome Measures

Physiological Measures: Rates of new fractures within 2 years following first vertebral fracture.

Patient Care Metrics

Post-vertebral fracture rates of dual energy x ray absorptiometry (DXA) testing, calcium and vitamin D supplementation, and pharmacotherapy for osteoporosis within 1 year post-fracture, and more than one year post fracture. Linear trend of the rate of new anti-osteoporosis pharmacotherapy among previously anti-osteoporosis medication naive patients within 1 year of fracture over time from 2008 to 2014.

Methods

All patients age 50 or older presenting to an emergency department with a vertebral fracture between 2008 and 2014 were included. Only an individual's first documented vertebral fracture was considered. Individuals were assessed for DXA screening, calcium and vitamin D supplementation, treatment with an anti-osteoporosis medication, and additional fractures following incident vertebral fracture. Statistical analyses included descriptive statistics and a simple logistic regression. No specific funding was provided for this study. The authors of this study report no relevant financial conflicts of interests or associated biases.

Results

Between 2008 and 2014, 2933 unique patients were seen at an included emergency department for one or more vertebral fracture encounters. Ninety-eight percent did not receive a DXA scan within the preceding two years or one year following fracture. Seven percent of patients were started on antiresorptive therapy after their fracture, with 341 (5%) starting within 1 year of fracture and 211 (2%) starting thereafter. Twenty-one percent (n = 616) had taken an antiresorptive medication before their fracture. Seventy three percent (n = 2128) were never prescribed antiresorptive therapy. Treatment rates slightly decreased over time. Thirty eight percent of patients presenting with a vertebral fracture (n = 1115) went on to develop a second fragility fracture within two years.

Conclusions

In the absence of a specific local program to improve secondary fracture prevention following minimal trauma spinal fractures, recognition and treatment of osteoporosis in patients at this institution remained dismal over time despite numerous calls to action on the topic in the orthopaedic literature and elsewhere. Undertreatment of osteoporosis puts patients at increased risk of incurring additional fractures. Within two years, 38% of the patients in this sample developed an additional fragility fracture. This study demonstrates a profound post-vertebral fracture osteoporosis care gap.

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