Hypofractionated Whole Breast Irradiation in Large-Breasted Women – Is There A Dosimetric Predictor for Acute Skin Toxicities?

Underutilization of hypofractionated whole breast irradiation (HF-WBI) in large-breasted women may be partially explained by concerns about dose heterogeneity and lack of validated dosimetric guidelines. We examined acute grade 3 dermatitis rates with HF-WBI in large-breasted patients when our institutionally-designed dosimetric guidelines are followed and evaluated predictors for skin toxicity. Whole breast CTV V105 >10% was a significant predictor of grade 3 dermatitis and is a useful parameter to guide optimization of breast radiation plans.

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