Retinoid-Sensitive Epigenetic Regulation of the Hoxb Cluster Maintains Normal Hematopoiesis and Inhibits Leukemogenesis

Hox genes are regulators of HSC maintenance and contributors in leukemogenesis. Li and colleagues elucidate a mechanism for how the retinoid-dependent cis-regulatory element DERARE maintains normal hematopoiesis but prevents leukemogenesis by coordinate regulation of Hoxb cluster genes in a methylation-dependent manner.

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