Blood Development: Hematopoietic Stem Cell Dependence and Independence

Dzierzak and Bigas review the current knowledge on molecular/cell trajectories that generate the complete hematopoietic system, informed by classical embryological and genetic experiments, cell fate tracing data, single-cell imaging, and transcriptomics studies. The authors also discuss the current developmentally informed efforts toward generating engraftable and multilineage blood cells.

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