Efficacy of Granulocyte Colony Stimulating Factor and N-acetyl Cysteine Therapies in Patients with Severe Alcoholic Hepatitis

Patients with alcoholic hepatitis (AH) have high mortality, so new therapies are needed. Administration of granulocyte colony stimulating factor (GCSF) increases survival times of patients with AH. It is not known whether addition of N-acetyl cysteine (NAC) to GCSF could further increase survival time. We performed a randomized controlled pilot study to compare the efficacy of standard medical therapy with pentoxifylline to treatment with a combination of GCSF and standard medical therapy as well as to the combination of NAC, GCSF, and standard medical therapy in patients with severe AH.

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