Abscopal effects with hypofractionated schedules extending into the effector phase of the tumor-specific T cell response

Hypofractionated radiotherapy (hRT) combined with immune checkpoint blockade (ICB) can induce T cell-mediated local and abscopal antitumor effects. We previously observed peak levels of tumor-infiltrating lymphocytes (TILs) between day 5 and day 8 after hRT; since TILs are regarded as radiosensitive, hRT schedules extending into this period might be less immunogenic, prompting us to compare clinically relevant, short and extended schedules with equivalent biologically effective doses in combination with anti-PD1 antibody treatment.

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