Stereotactic Radiosurgery for Resected Brain Metastases: New Evidence Supports a Practice Shift, but Questions Remain

Brain metastases are a common and devastating complication of cancer. Surgical resection of brain metastases remains an important treatment modality, especially for larger lesions with symptomatic mass effect. However, recurrence in the surgical bed occurs in approximately 60% of cases following resection alone (1, 2). For decades, the addition of postoperative adjuvant whole-brain radiation therapy (WBRT) has been the standard of care on the basis of randomized studies demonstrating efficacy in reducing the risk of recurrence in the surgical bed and the incidence of new metastases (1, 2).

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