Chromatin Configuration Affects the Dynamics and Distribution of a Transiently Interacting Protein

We present a theoretical study of the interaction between a protein (diffusing particle) and chromatin (polymer chain). Each monomer is a trap where a particle can transiently bind. We derive, to our knowledge, novel formulas for the transition rate between monomer sites, given a specific polymer configuration, and find that a particle is likely to rapidly rebind many times to its release site before moving to another site. The reattachment probability is larger when the local density around the release site is smaller.

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