In Reply to Overgaard et al

To the Editor: We appreciate Dr Overgaard's comments regarding our recent analysis of US fractionation patterns in early-stage glottic cancer (1, 2). He raises 2 intriguing points: first, whether the survival difference that we and others (3) have observed between fractionation schedules is plausible given highly effective surgical salvage; and second, whether the survival difference may be better explained by total duration of radiation therapy than by dose per fraction.

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