Observe, and Keep Chemotherapy Up the Sleeve

In this case of an adult with completely resected disease (1), the choices for therapy are observation or radiation therapy alone. Extrapolating from a pediatric population with residual disease per Children's Oncology Group study AHOD03P1, chemotherapy (adriamycin, vincristine, prednisone, and cyclophosphamide) would be supported because it confers an excellent 5-year event-free survival of 88.1% (2). Additionally, those patients with resected disease who were observed had a 5-year event-free survival of 77%.

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