Single-Molecule Spectroscopy: In Situ Two-Step Photoreduced SERS Materials for On-Chip Single-Molecule Spectroscopy with High Reproducibility (Adv. Mater. 36/2017)

Highly reproducible on-chip single-molecule Raman detection is achieved by developing a two-step photoreduction approach to incorporate surface-enhanced Raman scattering (SERS) materials with microfluidics, as reported by Zhipeng Li and co-workers in article number 1702893. The detection limit for various types of molecules can be as low as 10⁻¹³m with reproducibility of about 50%. This work may lead to substantial advances in single-molecule spectroscopy and quantitative SERS detection.

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