Using Indocyanine Green Extraction to Predict Liver Function After Stereotactic Body Radiotherapy for Hepatocellular Carcinoma

Indocyanine green (ICG) is a direct measure of hepatocyte function. Incorporation of ICG with standard clinical factors significantly improves the prediction of post SBRT liver function when toxicity is defined by an increase of Child Pugh (CP) > 2 or change in absolute albumin-bilirubin (ALBI) score > 0.5 or ALBI grade > 1. The use of ICG may facilitate the delivery of the maximum safe dose of radiation for patients with hepatocellular carcinoma and has the potential to improve uncomplicated tumor control and survival.

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