Co-Delivery of Drugs and Genes Using Polymeric Nanoparticles for Synergistic Cancer Therapeutic Effects

Abstract

Drug and gene delivery systems based on nanoparticles, microparticles and hydrogels have been widely studied for cancer treatment in the past decade. To achieve an efficient and safe delivery, selection of drug and gene delivery carrier is critical. Biocompatible polymeric nanoparticles are considerably promising carrier candidates in delivery of drugs and genes because of their unique chemical and physical properties. However, delivery of a drug or gene sometimes cannot achieve a satisfactory treatment effect. Therefore, co-delivery of dual drugs or co-delivery of a drug and a gene in a polymeric nanoparticle has attracted attention. Such co-delivery systems can overcome multi-drug resistance of chemical drugs and achieve a synergistic therapeutic effect. In this progress report, we summarize recent progress in the preparation and application of polymeric drug and gene co-delivery nanosystems. The remaining challenges and future trends in this field are also included.

Polymeric nanoparticles-mediated combination therapy is an effective strategy in cancer treatment. Co-delivery of dual drugs or drug/gene can enhance anti-cancer efficacy due to a synergistic effect. Moreover, polymeric nanocarriers can improve biodistribution of the therapeutics as well as release them at target sites. In this Progress Report, recent progresses in preparation and application of polymeric drug and gene co-delivery nanosystems are summarized.

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