Cancer Therapy: Biotransporting Self-Assembled Nanofactories Using Polymer Vesicles with Molecular Permeability for Enzyme Prodrug Cancer Therapy (Adv. Mater. 36/2017)

In article number 1702406, Kazunari Akiyoshi and co-workers develop self-assembled nanofactories formulated with intrinsically molecular permeable polymer vesicles. Because of this permeability, enzyme-loaded vesicles act as enzyme reactors, enabling the diffusion of a variety of low-molecular-weight substrates, including clinical prodrugs, to react with the retained encapsulated enzymes in vitro and in vivo. Thus, the vesicles serve as nanofactories that can transform prodrugs into drugs at tumor sites for cancer therapy.

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