A systematic review of normal-tissue complication models relevant to standard fractionation radiation therapy of the head and neck region published after the QUANTEC reports

There has recently been an increasing interest in model-based evaluation and comparison of different treatment options in radiation oncology studies. This is partly driven by the considerable technical advancements in radiation therapy of the last decade, leaving radiation oncologists with a multitude of options to consider. In lieu of randomized trials comparing all of these different treatment options for varying indications, which is unfeasible, treatment evaluations based on normal-tissue complication probability (NTCP) models offer a practical alternative.

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