11:08
Head and Neck Cancers by Alexandros G. Sfakianakis
Abstract Purpose The aim of this study was to accurately determine the prevalence of obstructive sleep apnoea (OSA) in patients with epilepsy (PWE) and to evaluate the efficacy of seizure control after treating OSA. Methods Articles were identified through a search of both MEDLINE and Embase. The...
11:08
Head and Neck Cancers by Alexandros G. Sfakianakis
Butorphanol tartrate (BT), a mixed [micro]/[kappa]/[delta] opioid receptor agonist, is one of the most potent orexigens known to date. The central mechanisms through which BT causes hyperphagia are largely unknown. Interestingly, BT suppresses meal-end activation of neurons synthesizing anorexigenic...
11:06
OtoRhinoLaryngology by Alexandros G.Sfakianakis
Abstract Purpose The aim of this study was to accurately determine the prevalence of obstructive sleep apnoea (OSA) in patients with epilepsy (PWE) and to evaluate the efficacy of seizure control after treating OSA. Methods Articles were identified through a search of both MEDLINE and Embase. The...
11:05
News in OtoRhinoLaryngology - Alexandros G. Sfakianakis
Abstract Purpose The aim of this study was to accurately determine the prevalence of obstructive sleep apnoea (OSA) in patients with epilepsy (PWE) and to evaluate the efficacy of seizure control after treating OSA. Methods Articles were identified through a search of both MEDLINE and Embase. The...
10:58
Νευρολογία κ' Νευροχειρουργική
Butorphanol tartrate (BT), a mixed [micro]/[kappa]/[delta] opioid receptor agonist, is one of the most potent orexigens known to date. The central mechanisms through which BT causes hyperphagia are largely unknown. Interestingly, BT suppresses meal-end activation of neurons synthesizing anorexigenic...
10:58
Νευρολογία κ' Νευροχειρουργική
In this issue of the Journal of Neuro-Ophthalmology, M. Tariq Bhatti, MD and Mark Moster, MD discuss the following 6 articles: 1. Feuer WJ, Schiffman JC, Davis JL, Porciatti V, Gonzalez P, Koilkonda RD, Yuan H, Lalwani A, Lam BL, Guy J. Gene therapy for Leber hereditary optic neuropathy: initial results....
10:58
Νευρολογία κ' Νευροχειρουργική
Background: Although patients with acute optic neuritis (ON) recover high-contrast visual acuity (HCVA) to 20/40 or better in 95% of affected eyes, patients with a history of ON continue to note subjective abnormalities of vision. Furthermore, substantial and permanent thinning of the retinal nerve fiber...
10:53
Human Diseases
Purpose: To compare clinical and free-living walking cadence in school-age children, and examine how allometric scaling of leg length variability affects objective ambulatory activity assessment. Methods: 375 children (154 boys, 221 girls; 9-11 years) completed GAITRite-determined slow, normal, and fast...
10:53
Human Diseases
Aerobic exercise training, and to a lesser degree, dynamic resistance training, are recommended to lower blood pressure (BP) among adults with hypertension. Yet, the combined influence of these exercise modalities, termed concurrent exercise training (CET), on resting BP is unclear. Purpose: Meta-analyze...
10:53
Human Diseases
Purpose: Older adults walk slower than young adults but it is not known why. Previous research suggests that ankle plantarflexors may have a crucial role in the reduction of walking speed. The purpose of this study was to investigate age-related differences in triceps surae muscle-tendon function during...
10:53
Human Diseases
Physical activity (PA) has numerous health benefits, particularly for those with diabetes. However, rates of long-term PA participation are often poor. Purpose: This study examined the effect of an intensive lifestyle intervention (ILI) on objectively-assessed PA over a 4-year period among older adults...
10:53
Human Diseases
Endurance athletes have a high prevalence of airway diseases, some possibly representing adaptive mechanisms to the need of conditioning large volumes of inspired air during high ventilation in specific environments. The aim of this study is to assess the ability to condition (warm and humidify) inspired...
10:53
Human Diseases
Purpose: To compare 24-h and postprandial glucose responses to incremental intervals of standing (STAND), walking (WALK) and cycling (CYCLE) to a sit-only (SIT) condition. Methods: Nine overweight/obese (BMI= 29 +/- 3 kg.m2) adults (30 +/- 15 yr) participated in this randomized crossover full-factorial...
10:53
Human Diseases
Introduction: Few physical activity interventions have been undertaken in infants and toddlers, despite concerns they are insufficiently active. The Prevention of Overweight in Infancy trial encouraged parents to be physically active with their child from birth, including prone-based play ('tummy time'),...
10:43
Νευρολογία κ' Νευροχειρουργική
Publication date: Available online 29 July 2016Source:Pediatric Neurology Author(s): Raphael Schiffmann, Markus Ries BackgroundFabry disease, an X-linked disorder of glycosphingolipids, markedly increases the risk of systemic vasculopathy, ischemic stroke, small-fiber peripheral neuropathy, cardiac...
10:33
Emergency Medicine by Alexandros G. Sfakianakis
Objectives: To compare internal jugular vein and subclavian vein access for central venous catheterization in terms of success rate and complications. Design: A 1:1 randomized controlled trial. Setting: Baskent University Medical Center. Patients: Pediatric patients scheduled for cardiac surgery. Interventions:...
10:33
Emergency Medicine by Alexandros G. Sfakianakis
Objectives: The goal of this study was to retrospectively evaluate the clinical impact of an accurate autocorrecting blood glucose monitoring system in children with severe burns. Blood glucose monitoring system accuracy is essential for providing appropriate intensive insulin therapy and achieving tight...
10:33
Emergency Medicine by Alexandros G. Sfakianakis
Objectives: Hyperglycemia after cardiac surgery and cardiopulmonary bypass in children has been associated with worse outcome; however, causality has never been proven. Furthermore, the benefit of tight glycemic control is inconsistent. The purpose of this study was to describe the metabolic constellation...
10:33
Emergency Medicine by Alexandros G. Sfakianakis
Objectives: Acute kidney injury may be promoted by critical illness, preexisting medical conditions, and treatments received both before and during ICU admission. We aimed to estimate the frequency of acute kidney injury during ICU treatment and to determine factors, occurring both before and during...
10:33
Emergency Medicine by Alexandros G. Sfakianakis
Objectives: To characterize the determinants of platelet transfusion in a PICU and determine whether there exists an association between platelet transfusion and adverse outcomes. Design: Prospective observational single center study, combined with a self-administered survey. Setting: PICU of Sainte-Justine...
10:29
OroFacial Medicine by Alexandros G.Sfakianakis
Abstract Objectives This study investigated chewing function in elderly individuals with Alzheimer's disease (AD) and correlated chewing function with cognitive status. Materials and methods Sixteen elderly individuals with mild AD (mean age 76.7 ± 6.3 years; 8 men, 8 women) and 16 age and gender-matched...
10:29
OroFacial Medicine by Alexandros G.Sfakianakis
Bruxism is a repetitive jaw-muscle activity characterized by clenching or grinding of the teeth and/or bracing or thrusting of the mandible. Recent advances have clarified the relationship between gastroesophageal reflux and sleep bruxism (SB). However, the influence of pharmacological elimination of...
10:19
Θεραπεία
No abstract available from Therapeutics via xlomafota13 on Inoreader http://ift.tt/2aE57o6
10:18
Θεραπεία
T-lymphocytes genetically engineered with the chimeric antigen receptor (CAR-T) have shown great therapeutic potential in cancer treatment. A variety of preclinical researches and clinical trials of CAR-T therapy have been carried out to lay the foundation for future clinical application. In these researches,...
10:18
Θεραπεία
Although the same treatment strategy as used for small cell lung cancer, including second-line chemotherapy, is generally applied to metastatic neuroendocrine carcinoma (NEC) and mixed adenoneuroendocrine carcinoma (MANEC) of the gastrointestinal tract (GIT; GIT-NEC/MANEC), the efficacy of amrubicin...
10:18
Θεραπεία
Evofosfamide, also formerly known as TH-302, is an investigational hypoxia-activated prodrug and is used to target cancerous cells under hypoxic conditions, which is a feature possessed by multiple solid tumors including pancreatic tumors. Gemcitabine, a cytotoxic agent, has for many years been the standard...
10:18
Θεραπεία
Ototoxicity continues to be a major dose-limiting side effect of cis-diamminedichloroplatinum(II) (cisplatin). With an ongoing need to develop pharmaceutical protection strategies for cisplatin's ototoxicity, there is also a need to develop stable in-vivo mammalian models of cisplatin ototoxicity. The...
10:18
Θεραπεία
Radiotherapy and adjuvant cisplatin chemotherapy are the mainstream approaches in the treatment of nasopharyngeal carcinoma (NPC). These have been shown to effectively improve the outcome and reduce tumor recurrence. However, radiotherapy and chemotherapy resistance during the course of treatment has...
10:18
Θεραπεία
Metastatic squamous cell carcinoma (SCCA) anal cancer is relatively rare. With limited data, cisplatin plus 5-fluorouracil has traditionally been utilized in the first-line setting. Treatment beyond front-line cisplatin progression is not well defined. Epidermal growth factor receptor (EGFR) is highly...
10:18
Θεραπεία
The A33 protein, expressed in colorectal tumors, is a target for improving treatment of patients with colorectal cancer. Over the last decade, studies have tested anti-A33 antibody as a therapeutic agent for these patients. Preclinical results were promising, but clinical trials did not confirm positive...
10:18
Θεραπεία
Pancreatic cancer is among the leading causes of cancer death in the USA, with limited effective treatment options. A major contributor toward the formation and persistence of pancreatic cancer is the dysregulation of the hepatocyte growth factor (HGF)/Met (HGF receptor) and the macrophage-stimulating...
10:18
Θεραπεία
We have previously reported the cytotoxic effects of chalcone A1, derived from 1-naphthaldehyde, in leukemia cell lines. On the basis of these findings, the main aim of this study was to elucidate some of the molecular mechanisms involved in apoptosis induced by chalcone A1 toward K562 and Jurkat cells....
10:18
Θεραπεία
Preoperative chemoradiotherapy (CRT) is generally performed for locally advanced rectal cancer (LARC, cStage 2 or 3) to improve local disease control and patient survival. The pathological tumor response to CRT is a surrogate marker that is associated with oncological outcome. Thus, markers that predict...
10:18
Θεραπεία
Docetaxel-based chemotherapy has been recommended for advanced nasopharyngeal carcinoma (NPC). However, treatment failure often occurs because of acquired drug resistance. In this study, a docetaxel-resistant NPC cell line CNE-2R was established with increasing doses of docetaxel for more than 6 months....
10:18
Θεραπεία
The combination of daunorubicin and cytarabine is the cornerstone of induction therapy for acute myeloid leukemia (AML). Little data are available on the optimal chemotherapy regimen for patients with AML and advanced renal failure, with some authors recommending administration of reduced daunorubicin...
10:18
Θεραπεία
Bromodomain and extraterminal protein (BET) inhibitors suppress the expression of c-MYC. U266, a human myeloma cell line, expresses the MYCL gene, but not the c-MYC gene. Our aim was to analyse the antimyeloma activity of BET inhibitors on U266 cells. Two BET inhibitors, I-BET151 and JQ1, were tested....
10:18
Θεραπεία
No abstract available from Therapeutics via xlomafota13 on Inoreader http://ift.tt/2al82zX
09:43
Νευρολογία κ' Νευροχειρουργική
No abstract available from NeuroSurgery via xlomafota13 on Inoreader http://ift.tt/2aDy8ki via IFTTT
09:43
Νευρολογία κ' Νευροχειρουργική
No abstract available from NeuroSurgery via xlomafota13 on Inoreader http://ift.tt/2aFuDGW via IFTTT
09:43
Νευρολογία κ' Νευροχειρουργική
No abstract available from NeuroSurgery via xlomafota13 on Inoreader http://ift.tt/2aDxEL6 via IFTTT
09:43
Νευρολογία κ' Νευροχειρουργική
Intracranial pressure (ICP) is the pressure inside the bony calvarium and can be affected by a variety of processes, such as intracranial masses and edema, obstruction or leakage of cerebrospinal fluid, and obstruction of venous outflow. This review focuses on the imaging of 2 important but less well...
09:43
Νευρολογία κ' Νευροχειρουργική
No abstract available from NeuroSurgery via xlomafota13 on Inoreader http://ift.tt/2aDxFi8 via IFTTT
09:43
Νευρολογία κ' Νευροχειρουργική
BACKGROUND: Embolic protection devices are used during carotid artery stenting procedures to reduce risk of distal embolization. Although this is a standard procedural recommendation, no studies have shown superiority of these devices over unprotected stenting procedures. OBJECTIVE: To assess the periprocedural...
09:43
Νευρολογία κ' Νευροχειρουργική
Publication date: December 2016Source:Current Opinion in Neurobiology, Volume 41 Author(s): Zhenyu Liu, Ali S Hamodi, Kara G Pratt The retinotectal circuit is the major component of the amphibian visual system. It is comprised of the retinal ganglion cells (RGCs) in the eye, which project their axons...
09:43
Νευρολογία κ' Νευροχειρουργική
In this issue of the Journal of Neuro-Ophthalmology, M. Tariq Bhatti, MD and Mark Moster, MD discuss the following 6 articles: 1. Feuer WJ, Schiffman JC, Davis JL, Porciatti V, Gonzalez P, Koilkonda RD, Yuan H, Lalwani A, Lam BL, Guy J. Gene therapy for Leber hereditary optic neuropathy: initial results....
09:14
Νευρολογία κ' Νευροχειρουργική
Background: Although patients with acute optic neuritis (ON) recover high-contrast visual acuity (HCVA) to 20/40 or better in 95% of affected eyes, patients with a history of ON continue to note subjective abnormalities of vision. Furthermore, substantial and permanent thinning of the retinal nerve fiber...
08:59
OroFacial Medicine by Alexandros G.Sfakianakis
It is well known that exposure to maternal separation (MS) in early life causes plastic changes in the nervous system in adulthood, occasionally resulting in ubiquitous chronic pain. However, the pathogenic mechanisms of pain hypersensitivity remain unclear. Here, the authors examined the involvement...
08:48
Θεραπεία
Repression of phosphoglycerate dehydrogenase sensitizes triple-negative breast cancer to doxorubicin
Abstract Purpose Approximately 70 % of triple-negative breast cancer (TNBC) cell lines are identified to upregulate phosphoglycerate dehydrogenase (PHGDH), which regulates the intracellular synthesis of serine and glycine, and promotes tumor growth. In this work, the impact of this pathway on doxorubicin...
07:58
Human Diseases
from Sports Medicine via xlomafota13 on Inoreader http://ift.tt/2aDVSEp
07:58
Human Diseases
from Sports Medicine via xlomafota13 on Inoreader http://ift.tt/2aDWObM
07:58
Human Diseases
from Sports Medicine via xlomafota13 on Inoreader http://ift.tt/2agETEE
07:58
Human Diseases
from Sports Medicine via xlomafota13 on Inoreader http://ift.tt/2agEulE
07:58
Human Diseases
from Sports Medicine via xlomafota13 on Inoreader http://ift.tt/2aDWaLy
07:58
Human Diseases
from Sports Medicine via xlomafota13 on Inoreader http://ift.tt/2aDVBkW
07:58
Human Diseases
We would like to touch on some of the comments made in the Letter to the Editor entitled “Introduction of a Predictive Model for Epidural Steroid Injections Leads to Inappropriate and Inaccurate Conclusions.”from Sports Medicine via xlomafota13 on Inoreader http://ift.tt/2agEDpl
07:58
Human Diseases
Mai HT, Mitchell SM, Hashmi SZ, Jenkins TJ, Patel AA, Hsu WK. Differences in bone mineral density of fixation points between lumbar cortical and traditional pedicle screws. Spine J 2016:16:835–41 (in this issue).from Sports Medicine via xlomafota13 on Inoreader http://ift.tt/2agErXg
07:58
Human Diseases
Sivaganesan et al.'s [1] introduction of a predictive model using the patient and the disease-specific effectiveness of lumbar epidural steroid injections in degenerative spine disorders is a worthwhile idea but suffers from limitations.from Sports Medicine via xlomafota13 on Inoreader http://ift.tt/2agEgLv
07:58
Human Diseases
from Sports Medicine via xlomafota13 on Inoreader http://ift.tt/2aDVVQK
07:58
Human Diseases
COMMENTARY ON: Xiao R, Miller JA, Margetis K, et al. Radiographic progression of vertebral fractures in patients with multiple myeloma. Spine J 2016:16:822–32 (in this issue).from Sports Medicine via xlomafota13 on Inoreader http://ift.tt/2agEhyW
07:45
Anatomy Pathology
Thyroid-like follicular carcinoma of the kidney (TLFCK) is a rare but emerging renal neoplasm that morphologically mimics follicular carcinoma of the thyroid but lacks immunohistochemical expression of thyroid markers such as TTF-1 and thyroglobulin. Here, a case of an incidentally discovered TLFCK in...
07:31
Λοίμωξη
Sedge-dominated wetlands on the Qinghai–Tibetan Plateau are methane emission centers. Methanotrophs at these sites play a role in reducing methane emissions, but relatively little is known about the composition of active methanotrophs in these wetlands. Here, we used DNA stable isotope probing to identify...
07:31
Λοίμωξη
This commentary describes an assessment exercise known as the TRIPSE (Tri-Partite Problem Solving Exercise) that mimics science in operation. Students frame hypotheses based on limited data, design experiments to test them, which they later revise with new information. It is emphasised that there are...
07:31
Λοίμωξη
The OmpA-like protein domain has been associated with peptidoglycan-binding proteins, and is often found in virulence factors of bacterial pathogens. The intracellular pathogen Legionella pneumophila encodes for six proteins that contain the OmpA-like domain, among them the highly conserved uncharacterized...
07:31
Λοίμωξη
Pseudomonas aeruginosa is an opportunistic pathogen with high resistance to a wide variety of antimicrobials. The multidrug resistance pump MexAB-OprM promotes the efflux of various antibiotics, mostly when mutations accumulate in the transcriptional regulators MexR, NalC and NalD, thereby causing MexAB-OprM...
07:31
Λοίμωξη
Numerous national reports have addressed the need for changing how science courses in higher education are taught, so that students develop a deeper understanding of critical concepts and the analytical and cognitive skills needed to address future challenges. This review presents some evidence-based...
07:31
Λοίμωξη
Two-component systems (TCS) allow a cell to elaborate a variety of adaptive responses to environment changes. The recently discovered CasK/R TCS plays a role in the optimal unsaturation of fatty acids necessary for cold adaptation of the foodborne-pathogen Bacillus cereus. Here, we showed that the promoter...
07:31
Λοίμωξη
The 16S rRNA gene (16S rDNA) codes for RNA that plays a fundamental role during translation in the ribosome and is used extensively as a marker gene to establish relationships among bacteria. However, the complementary non-coding 16S rDNA (nc16S rDNA) has been ignored. An idea emerged in the course of...
07:31
Λοίμωξη
In sulfidic environments, microbes oxidize reduced sulfur compounds via several pathways. We used metagenomics to investigate sulfur metabolic pathways from microbial mat communities in two subterranean sulfidic streams in Lower Kane Cave, WY, USA and from Glenwood Hot Springs, CO, USA. Both unassembled...
07:30
Λοίμωξη
Sedge-dominated wetlands on the Qinghai–Tibetan Plateau are methane emission centers. Methanotrophs at these sites play a role in reducing methane emissions, but relatively little is known about the composition of active methanotrophs in these wetlands. Here, we used DNA stable isotope probing to identify...
07:30
Λοίμωξη
This commentary describes an assessment exercise known as the TRIPSE (Tri-Partite Problem Solving Exercise) that mimics science in operation. Students frame hypotheses based on limited data, design experiments to test them, which they later revise with new information. It is emphasised that there are...
07:30
Λοίμωξη
The OmpA-like protein domain has been associated with peptidoglycan-binding proteins, and is often found in virulence factors of bacterial pathogens. The intracellular pathogen Legionella pneumophila encodes for six proteins that contain the OmpA-like domain, among them the highly conserved uncharacterized...
07:30
Λοίμωξη
Pseudomonas aeruginosa is an opportunistic pathogen with high resistance to a wide variety of antimicrobials. The multidrug resistance pump MexAB-OprM promotes the efflux of various antibiotics, mostly when mutations accumulate in the transcriptional regulators MexR, NalC and NalD, thereby causing MexAB-OprM...
07:30
Λοίμωξη
Numerous national reports have addressed the need for changing how science courses in higher education are taught, so that students develop a deeper understanding of critical concepts and the analytical and cognitive skills needed to address future challenges. This review presents some evidence-based...
07:30
Λοίμωξη
Two-component systems (TCS) allow a cell to elaborate a variety of adaptive responses to environment changes. The recently discovered CasK/R TCS plays a role in the optimal unsaturation of fatty acids necessary for cold adaptation of the foodborne-pathogen Bacillus cereus. Here, we showed that the promoter...
07:30
Λοίμωξη
The 16S rRNA gene (16S rDNA) codes for RNA that plays a fundamental role during translation in the ribosome and is used extensively as a marker gene to establish relationships among bacteria. However, the complementary non-coding 16S rDNA (nc16S rDNA) has been ignored. An idea emerged in the course of...
07:30
Λοίμωξη
In sulfidic environments, microbes oxidize reduced sulfur compounds via several pathways. We used metagenomics to investigate sulfur metabolic pathways from microbial mat communities in two subterranean sulfidic streams in Lower Kane Cave, WY, USA and from Glenwood Hot Springs, CO, USA. Both unassembled...
02:02
OroFacial Medicine by Alexandros G.Sfakianakis
The rehabilitation of edentulous atrophic mandibles with dental implants is often threatened where there has been loss of horizontal alveolar bone. Techniques to augment the bone include guided bony regeneration, distraction osteogenesis, ridge splitting osteotomy, onlay grafting with block grafts (autologous...
01:22
Θεραπεία
To evaluate non-coplanar volumetric modulated arc radiotherapy (VMAT) trajectories for organ at risk (OAR) sparing in primary brain tumor radiotherapy. from Therapeutics via xlomafota13 on Inoreader http://ift.tt/2awHLjp
01:19
Λοίμωξη
Recently, one of the Journal of Bacteriology Classic Spotlight series highlighted the numerous studies on bacterial spores that have been published in the journal throughout the years. Bacterial endospores, the resilient and relatively quiescent bacterial structures first identified in the 1800s... ...
01:14
Human Diseases
AbstractBackgroundMycobacterium tuberculosis (Mtb) remains an unresolved threat resulting in great annual loss of life. The role of B cells during the protective immunity to Mtb is still unclear. B cells have been described as effector cells in addition to their role as antibody producing cells during...
01:14
Human Diseases
AbstractSince 2006, the Veterans Health Administration (VHA) has instituted policy changes and training programs to support system-wide implementation of two evidence-based psychotherapies (EBPs) for posttraumatic stress disorder (PTSD). To assess lessons learned from this unprecedented effort, we used...
01:10
News in OtoRhinoLaryngology - Alexandros G. Sfakianakis
Professional voice users, such as singers and teachers, are at greater risk of developing vocal fold injury from excessive use of voice; thus, protection of the vocal fold is essential. One of the most important factors that aggravates injury is the production of reactive oxygen species at the wound...
01:10
News in OtoRhinoLaryngology - Alexandros G. Sfakianakis
The field of music is increasingly gaining scope and attracting researchers from varied fields in terms of improvising the art of voice modulation in singing. There has been a lot of competition, and young budding singers are emerging with more talent. This study is aimed to develop software to differentiate...
01:01
OroFacial Medicine by Alexandros G.Sfakianakis
Thank you for giving us the chance to reply to the Letter to the Editor critiquing certain aspects of our article "Does the piezoelectric surgical technique produce fewer postoperative sequelae after lower third molar surgery than conventional rotary instruments? A systematic review and meta-analysis".1...
00:26
Emergency Medicine by Alexandros G. Sfakianakis
Rapid Sequencing of Awake IntubationEMCrit by Scott Weingart.from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/2a5ghSd
00:18
Θεραπεία
Summary Anaplastic lymphoma kinase 1 (ALK-1) is a member of the insulin receptor tyrosine kinase family. In clinical practice, three small molecule inhibitors of ALK-1 are used, namely crizotinib, ceritinib and alectinib. Several more agents are in active pre-clinical and clinical studies. Crizotinib...
00:18
Θεραπεία
Summary Histone deacetylase (HDAC) inhibitors are now intensively investigated as potential cytostatic agents in many malignancies. Here, we provide novel information concerning the influence of belinostat (Bel), a hydroxamate-based pan-HDAC inhibitor, on glioblastoma LN-229 and LN-18 cells. We found...
Fri Jul 29, 2016 23:59
OroFacial Medicine by Alexandros G.Sfakianakis
Abstract Objective The aim of this study was to establish global survival rates and potential prognostic factors for mucoepidermoid carcinoma (MC) of the salivary glands in patients diagnosed at the Dr. Eduardo Cáceres Graziani National Institute for Neoplastic Diseases (INEN), Lima, Peru, between...
Fri Jul 29, 2016 23:15
Λοίμωξη
Washington, DC – July 29, 2016 - Many deadly diseases that afflict humans were originally acquired through contact with animals. New research published in ASM's Applied and Environmental Microbiology shows that pathogens can also jump the species barrier to move from humans to animals. The study... ...
Fri Jul 29, 2016 22:50
Θεραπεία
Abstract Pasireotide (Signifor®) long-acting release (LAR) is a next-generation somatostatin receptor ligand (SRL) approved for treatment of patients with acromegaly who have had an inadequate response to surgery or for whom surgery is not an option. Pasireotide LAR has been shown to be more effective...
Fri Jul 29, 2016 22:36
Θεραπεία
Publication date: Available online 29 July 2016Source:Radiotherapy and Oncology Author(s): Gregory Smyth, Philip M. Evans, Jeffrey C. Bamber, Henry C. Mandeville, Liam C. Welsh, Frank H. Saran, James L. Bedford Background and purposeTo evaluate non-coplanar volumetric modulated arc radiotherapy (VMAT)...
Fri Jul 29, 2016 22:05
Θεραπεία
Abstract Background In Ireland, all new drugs are considered for a formal pharmacoeconomic evaluation (PE) prior to a reimbursement decision. All evaluations are conducted by the National Centre for Pharmacoeconomics (NCPE). The objectives of this study were to describe the evaluation process and to...
Fri Jul 29, 2016 20:28
Emergency Medicine by Alexandros G. Sfakianakis
Rapid Sequencing of Awake IntubationEMCrit by Scott Weingart.from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/2a5ghSd
Fri Jul 29, 2016 20:17
Θεραπεία
Abstract Since 1993, how to assess the causality of serious adverse events in premarketing drug clinical trials has undergone sustained regulatory evolution in the USA. In that year, an investigational drug study for chronic hepatitis B virus infection was emergently stopped after a patient suddenly...
Fri Jul 29, 2016 20:02
Θεραπεία
Summary Anaplastic lymphoma kinase 1 (ALK-1) is a member of the insulin receptor tyrosine kinase family. In clinical practice, three small molecule inhibitors of ALK-1 are used, namely crizotinib, ceritinib and alectinib. Several more agents are in active pre-clinical and clinical studies. Crizotinib...
Fri Jul 29, 2016 20:02
Θεραπεία
Summary Histone deacetylase (HDAC) inhibitors are now intensively investigated as potential cytostatic agents in many malignancies. Here, we provide novel information concerning the influence of belinostat (Bel), a hydroxamate-based pan-HDAC inhibitor, on glioblastoma LN-229 and LN-18 cells. We found...
Fri Jul 29, 2016 20:02
Θεραπεία
Abstract Purpose The Food and Drug Administration (FDA) and the European Medicines Agency (EMA) have both implemented procedures in order to shorten review time for marketing authorizations with potential therapeutic added value, called priority review and accelerated assessment procedure, respectively....
Fri Jul 29, 2016 19:58
OroFacial Medicine by Alexandros G.Sfakianakis
Abstract Purpose This patient study was designed to measure the validity of both the horizontal and Camper's planes, which are used as benchmarks to reestablish the sagittal orientation of the occlusal plane angles in dental rehabilitation. Materials and Methods Profile digital photographs...
Fri Jul 29, 2016 19:28
Anatomy Pathology
Abstract Aims Recent literature suggests that clinically silent, microscopic GISTs are common incidental findings. The aim of this study was to examine the histological, immunohistochemical and molecular characteristics of these tumours, which we have defined as measuring ≤ 20 mm, in order to determine...
Fri Jul 29, 2016 19:12
Λοίμωξη
Researchers as the University of Massachusetts are working with Geobacter by manipulating their genetic material. This manipulation makes the bacteria produce filaments of tryptophan, increasing the electrical conductivity of the bacteria by 2,000 times. The uses for these nanowires could be... from...
Fri Jul 29, 2016 19:12
Λοίμωξη
Have you ever gone to the beach, ready for a day of sun and sand, only to find a warning sign? One of the most common reasons beaches close is due to the presence of coliform bacteria. These indicator bacteria, such as Escherichia coli, are used as markers for fecal waste, since their presence c... ...
Fri Jul 29, 2016 18:49
News in OtoRhinoLaryngology - Alexandros G. Sfakianakis
We have recently talked about making soundscapes from photographs and a group of professional recording artists joining forces to document the exquisite sounds of nature. The real world, no doubt, is much more sonically diverse and full. Is there a way to capture the characteristic sounds of the...
Fri Jul 29, 2016 17:23
Human Diseases
To examine the association between exposure to para-dichlorobenzene, measured as urinary concentrations of 2,5-dichlorophenol (2,5-DCP), and thyroid function in US adolescents.from Pediatrics via xlomafota13 on Inoreader http://ift.tt/2alK7AQ
Fri Jul 29, 2016 17:23
Human Diseases
To examine the efficacy of a phonics-training program in children with neurofibromatosis type 1 (NF1) and reading difficulties.from Pediatrics via xlomafota13 on Inoreader http://ift.tt/2alJM18
Fri Jul 29, 2016 17:23
Human Diseases
A 4-year-old girl was referred for a cystic hepatic lesion discovered incidentally during ultrasound exploration. Hepatic magnetic resonance imaging (MRI) demonstrated a T1-hypointense and T2-hyperintense lesion of 18 × 15 × 13 mm compatible with a hepatic cyst or a ductal dilatation. 99mTc mebrofenin...
Fri Jul 29, 2016 17:23
Human Diseases
In 1907, G. F. Still wrote: “I know of no symptom which can be more obscure in its causation than colicky abdominal pain in childhood.”1 Nothing changed until John Apley, a British pediatrician, published his seminal work in 1958.2 He and his coauthor interviewed 1000 school-age children and their parents...
Fri Jul 29, 2016 17:23
Human Diseases
To evaluate the relationship between social determinants of health (SDH) and cardiovascular disease (CVD) risk factors as well as a measure of arterial stiffness in adolescents with type 1 diabetes (T1D).from Pediatrics via xlomafota13 on Inoreader http://ift.tt/2alKds1
Fri Jul 29, 2016 17:23
Human Diseases
To develop and validate a hierarchical decision tree model that combines neurobehavioral and physical measures to identify children affected by prenatal alcohol exposure even when facial dysmorphology is not present.from Pediatrics via xlomafota13 on Inoreader http://ift.tt/2a9lXpZ
Fri Jul 29, 2016 17:23
Human Diseases
Safety of the Manchester Triage System to Detect Critically Ill Children at the Emergency Department
To assess the safety of the Manchester Triage System in pediatric emergency care for children who require admission to the intensive care unit (ICU).from Pediatrics via xlomafota13 on Inoreader http://ift.tt/2alJYNC
Fri Jul 29, 2016 17:23
Human Diseases
To assess preferences of health care workers (HCWs) and parents of term and preterm infants to adverse health outcomes, and how perceived surgical mortality influences decision-making.from Pediatrics via xlomafota13 on Inoreader http://ift.tt/2a9m70s
Fri Jul 29, 2016 17:18
News in OtoRhinoLaryngology - Alexandros G. Sfakianakis
A precedence effect model is described that can use a binaural signal to robustly localize a sound source in the presence of multiple reflections for the frontal horizontal plane. The model also estimates a room impulse response from a running binaural signal and determines the spatial locations and...
Fri Jul 29, 2016 17:12
OroFacial Medicine by Alexandros G.Sfakianakis
Paramedian forehead flap represents a workhorse in facial soft tissue reconstruction but always requires a second step in order to interrupt the skin bridge. Direct visualization and dissection of vascular pedicle may avoid this drawback. from OroFacial Medicine via ola Kala on Inoreader http://ift.tt/2a9up8q...
Fri Jul 29, 2016 17:12
OroFacial Medicine by Alexandros G.Sfakianakis
It is essential to have a reliable assessment method in order to compare the results of cleft lip and palate surgery. In this study the computer-based program SymNose, a method for quantitative assessment of the nose and lip, will be assessed on usability and reliability. from OroFacial Medicine via...
Fri Jul 29, 2016 16:50
News in OtoRhinoLaryngology - Alexandros G. Sfakianakis
Passive Acoustic Mapping (PAM) enables real-time monitoring of ultrasound therapies by beamforming acoustic emissions emanating from the ultrasound focus. Reconstruction of the narrowband or broadband acoustic emissions component enables mapping of different physical phenomena, with narrowband emissions...
Fri Jul 29, 2016 16:50
News in OtoRhinoLaryngology - Alexandros G. Sfakianakis
Numerical modeling of wave propagation in acoustic tubes is a subject of longstanding interest, particularly for enclosures of varying cross section, and especially when viscothermal losses due to boundary layer effects are taken into consideration. Though steady-state, or frequency domain methods,...
Fri Jul 29, 2016 16:50
News in OtoRhinoLaryngology - Alexandros G. Sfakianakis
Acoustic black holes (ABHs) are effective, passive, lightweight vibration absorbers that have been developed and shown to effectively reduce the structural vibration and radiated sound of beam and plate structures. ABHs employ a local thickness change that reduces the speed of bending waves and increases...
Fri Jul 29, 2016 16:50
News in OtoRhinoLaryngology - Alexandros G. Sfakianakis
A precedence effect model is described that can use a binaural signal to robustly localize a sound source in the presence of multiple reflections for the frontal horizontal plane. The model also estimates a room impulse response from a running binaural signal and determines the spatial locations...
Fri Jul 29, 2016 16:41
OroFacial Medicine by Alexandros G.Sfakianakis
Publication date: Available online 28 July 2016Source:International Journal of Oral and Maxillofacial Surgery Author(s): H. Rushinek, R. Tabib, Y. Fleissig, M. Klein, S. Tshori The aims of the study were to evaluate the diagnostic accuracy and utility of the mean region of interest (ROI) and mean...
Fri Jul 29, 2016 16:29
Medical Imaging
Publication date: November 2016Source:Journal of Environmental Radioactivity, Volume 164 Author(s): Kyo Kitayama, Kenji Ohse, Nagayoshi Shima, Kencho Kawatsu, Hirofumi Tsukada The decreasing trend of the atmospheric 137Cs concentration in two cities in Fukushima prefecture was analyzed by a regression...
Fri Jul 29, 2016 16:18
News in OtoRhinoLaryngology - Alexandros G. Sfakianakis
Publication date: Available online 29 July 2016Source:Gait & Posture Author(s): Daniela Aldabe, Pedduzzi Marcelo Castro, Stephan Milosavljevic, Dawn Melanie Bussey Postural adjustment evaluations during single leg lift requires the initiation of heel lift (T1) identification. T1 measured by means...
Fri Jul 29, 2016 16:11
OroFacial Medicine by Alexandros G.Sfakianakis
First described by Jaffe in 1953, central giant cell lesions are defined by the World Health Organisation as "a localized benign but sometimes aggressive osteolytic proliferation consisting of fibrous tissue with haemorrhage and haemosiderin deposits, presence of osteoclast-like giant cells and reactive...
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