10:57
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
No abstract available from Aesthetics via xlomafota13 on Inoreader http://ift.tt/2a8EoMI
10:57
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
T-lymphocytes genetically engineered with the chimeric antigen receptor (CAR-T) have shown great therapeutic potential in cancer treatment. A variety of preclinical researches and clinical trials of CAR-T therapy have been carried out to lay the foundation for future clinical application. In these researches,...
10:57
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
Although the same treatment strategy as used for small cell lung cancer, including second-line chemotherapy, is generally applied to metastatic neuroendocrine carcinoma (NEC) and mixed adenoneuroendocrine carcinoma (MANEC) of the gastrointestinal tract (GIT; GIT-NEC/MANEC), the efficacy of amrubicin...
10:57
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
No abstract available from Therapeutics via xlomafota13 on Inoreader http://ift.tt/2aE57o6
10:57
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
Evofosfamide, also formerly known as TH-302, is an investigational hypoxia-activated prodrug and is used to target cancerous cells under hypoxic conditions, which is a feature possessed by multiple solid tumors including pancreatic tumors. Gemcitabine, a cytotoxic agent, has for many years been the standard...
10:57
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
Ototoxicity continues to be a major dose-limiting side effect of cis-diamminedichloroplatinum(II) (cisplatin). With an ongoing need to develop pharmaceutical protection strategies for cisplatin’s ototoxicity, there is also a need to develop stable in-vivo mammalian models of cisplatin ototoxicity. The...
10:57
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
Metastatic squamous cell carcinoma (SCCA) anal cancer is relatively rare. With limited data, cisplatin plus 5-fluorouracil has traditionally been utilized in the first-line setting. Treatment beyond front-line cisplatin progression is not well defined. Epidermal growth factor receptor (EGFR) is highly...
10:57
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
Radiotherapy and adjuvant cisplatin chemotherapy are the mainstream approaches in the treatment of nasopharyngeal carcinoma (NPC). These have been shown to effectively improve the outcome and reduce tumor recurrence. However, radiotherapy and chemotherapy resistance during the course of treatment has...
10:57
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
Pancreatic cancer is among the leading causes of cancer death in the USA, with limited effective treatment options. A major contributor toward the formation and persistence of pancreatic cancer is the dysregulation of the hepatocyte growth factor (HGF)/Met (HGF receptor) and the macrophage-stimulating...
10:57
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
The A33 protein, expressed in colorectal tumors, is a target for improving treatment of patients with colorectal cancer. Over the last decade, studies have tested anti-A33 antibody as a therapeutic agent for these patients. Preclinical results were promising, but clinical trials did not confirm positive...
10:57
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
Preoperative chemoradiotherapy (CRT) is generally performed for locally advanced rectal cancer (LARC, cStage 2 or 3) to improve local disease control and patient survival. The pathological tumor response to CRT is a surrogate marker that is associated with oncological outcome. Thus, markers that predict...
10:57
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
We have previously reported the cytotoxic effects of chalcone A1, derived from 1-naphthaldehyde, in leukemia cell lines. On the basis of these findings, the main aim of this study was to elucidate some of the molecular mechanisms involved in apoptosis induced by chalcone A1 toward K562 and Jurkat cells....
10:57
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
Docetaxel-based chemotherapy has been recommended for advanced nasopharyngeal carcinoma (NPC). However, treatment failure often occurs because of acquired drug resistance. In this study, a docetaxel-resistant NPC cell line CNE-2R was established with increasing doses of docetaxel for more than 6 months....
10:57
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
Bromodomain and extraterminal protein (BET) inhibitors suppress the expression of c-MYC. U266, a human myeloma cell line, expresses the MYCL gene, but not the c-MYC gene. Our aim was to analyse the antimyeloma activity of BET inhibitors on U266 cells. Two BET inhibitors, I-BET151 and JQ1, were tested....
10:57
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
The combination of daunorubicin and cytarabine is the cornerstone of induction therapy for acute myeloid leukemia (AML). Little data are available on the optimal chemotherapy regimen for patients with AML and advanced renal failure, with some authors recommending administration of reduced daunorubicin...
10:57
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
No abstract available from Therapeutics via xlomafota13 on Inoreader http://ift.tt/2al82zX
10:57
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
Abstract Objectives This study investigated chewing function in elderly individuals with Alzheimer’s disease (AD) and correlated chewing function with cognitive status. Materials...
10:56
THERAPY MEDICINE BY SFAKIANAKIS G.ALEXANDROS
No abstract available from Therapeutics via xlomafota13 on Inoreader http://ift.tt/2aE57o6 via IFTTT
10:56
THERAPY MEDICINE BY SFAKIANAKIS G.ALEXANDROS
T-lymphocytes genetically engineered with the chimeric antigen receptor (CAR-T) have shown great therapeutic potential in cancer treatment. A variety of preclinical researches and clinical trials of CAR-T therapy have been carried out to lay the foundation for future clinical application. In these researches,...
10:56
THERAPY MEDICINE BY SFAKIANAKIS G.ALEXANDROS
Although the same treatment strategy as used for small cell lung cancer, including second-line chemotherapy, is generally applied to metastatic neuroendocrine carcinoma (NEC) and mixed adenoneuroendocrine carcinoma (MANEC) of the gastrointestinal tract (GIT; GIT-NEC/MANEC), the efficacy of amrubicin...
10:56
THERAPY MEDICINE BY SFAKIANAKIS G.ALEXANDROS
Evofosfamide, also formerly known as TH-302, is an investigational hypoxia-activated prodrug and is used to target cancerous cells under hypoxic conditions, which is a feature possessed by multiple solid tumors including pancreatic tumors. Gemcitabine, a cytotoxic agent, has for many years been the standard...
10:56
THERAPY MEDICINE BY SFAKIANAKIS G.ALEXANDROS
Ototoxicity continues to be a major dose-limiting side effect of cis-diamminedichloroplatinum(II) (cisplatin). With an ongoing need to develop pharmaceutical protection strategies for cisplatin’s ototoxicity, there is also a need to develop stable in-vivo mammalian models of cisplatin ototoxicity. The...
10:56
THERAPY MEDICINE BY SFAKIANAKIS G.ALEXANDROS
Radiotherapy and adjuvant cisplatin chemotherapy are the mainstream approaches in the treatment of nasopharyngeal carcinoma (NPC). These have been shown to effectively improve the outcome and reduce tumor recurrence. However, radiotherapy and chemotherapy resistance during the course of treatment has...
10:56
THERAPY MEDICINE BY SFAKIANAKIS G.ALEXANDROS
Metastatic squamous cell carcinoma (SCCA) anal cancer is relatively rare. With limited data, cisplatin plus 5-fluorouracil has traditionally been utilized in the first-line setting. Treatment beyond front-line cisplatin progression is not well defined. Epidermal growth factor receptor (EGFR) is highly...
10:56
THERAPY MEDICINE BY SFAKIANAKIS G.ALEXANDROS
The A33 protein, expressed in colorectal tumors, is a target for improving treatment of patients with colorectal cancer. Over the last decade, studies have tested anti-A33 antibody as a therapeutic agent for these patients. Preclinical results were promising, but clinical trials did not confirm positive...
10:56
THERAPY MEDICINE BY SFAKIANAKIS G.ALEXANDROS
Pancreatic cancer is among the leading causes of cancer death in the USA, with limited effective treatment options. A major contributor toward the formation and persistence of pancreatic cancer is the dysregulation of the hepatocyte growth factor (HGF)/Met (HGF receptor) and the macrophage-stimulating...
10:56
THERAPY MEDICINE BY SFAKIANAKIS G.ALEXANDROS
We have previously reported the cytotoxic effects of chalcone A1, derived from 1-naphthaldehyde, in leukemia cell lines. On the basis of these findings, the main aim of this study was to elucidate some of the molecular mechanisms involved in apoptosis induced by chalcone A1 toward K562 and Jurkat cells....
10:56
THERAPY MEDICINE BY SFAKIANAKIS G.ALEXANDROS
Preoperative chemoradiotherapy (CRT) is generally performed for locally advanced rectal cancer (LARC, cStage 2 or 3) to improve local disease control and patient survival. The pathological tumor response to CRT is a surrogate marker that is associated with oncological outcome. Thus, markers that predict...
10:56
THERAPY MEDICINE BY SFAKIANAKIS G.ALEXANDROS
Docetaxel-based chemotherapy has been recommended for advanced nasopharyngeal carcinoma (NPC). However, treatment failure often occurs because of acquired drug resistance. In this study, a docetaxel-resistant NPC cell line CNE-2R was established with increasing doses of docetaxel for more than 6 months....
10:56
THERAPY MEDICINE BY SFAKIANAKIS G.ALEXANDROS
The combination of daunorubicin and cytarabine is the cornerstone of induction therapy for acute myeloid leukemia (AML). Little data are available on the optimal chemotherapy regimen for patients with AML and advanced renal failure, with some authors recommending administration of reduced daunorubicin...
10:56
THERAPY MEDICINE BY SFAKIANAKIS G.ALEXANDROS
Bromodomain and extraterminal protein (BET) inhibitors suppress the expression of c-MYC. U266, a human myeloma cell line, expresses the MYCL gene, but not the c-MYC gene. Our aim was to analyse the antimyeloma activity of BET inhibitors on U266 cells. Two BET inhibitors, I-BET151 and JQ1, were tested....
10:56
THERAPY MEDICINE BY SFAKIANAKIS G.ALEXANDROS
No abstract available from Therapeutics via xlomafota13 on Inoreader http://ift.tt/2al82zX via IFTTT
10:37
Cancer by Sfakianakis G.Alexandros
No abstract available from Cancer via xlomafota13 on Inoreader http://ift.tt/2aE57o6 via IFTTT
10:37
Cancer by Sfakianakis G.Alexandros
T-lymphocytes genetically engineered with the chimeric antigen receptor (CAR-T) have shown great therapeutic potential in cancer treatment. A variety of preclinical researches and clinical trials of CAR-T therapy have been carried out to lay the foundation for future clinical application. In these researches,...
10:37
Cancer by Sfakianakis G.Alexandros
Although the same treatment strategy as used for small cell lung cancer, including second-line chemotherapy, is generally applied to metastatic neuroendocrine carcinoma (NEC) and mixed adenoneuroendocrine carcinoma (MANEC) of the gastrointestinal tract (GIT; GIT-NEC/MANEC), the efficacy of amrubicin...
10:37
Cancer by Sfakianakis G.Alexandros
Ototoxicity continues to be a major dose-limiting side effect of cis-diamminedichloroplatinum(II) (cisplatin). With an ongoing need to develop pharmaceutical protection strategies for cisplatin’s ototoxicity, there is also a need to develop stable in-vivo mammalian models of cisplatin ototoxicity. The...
10:37
Cancer by Sfakianakis G.Alexandros
Evofosfamide, also formerly known as TH-302, is an investigational hypoxia-activated prodrug and is used to target cancerous cells under hypoxic conditions, which is a feature possessed by multiple solid tumors including pancreatic tumors. Gemcitabine, a cytotoxic agent, has for many years been the standard...
10:37
Cancer by Sfakianakis G.Alexandros
Radiotherapy and adjuvant cisplatin chemotherapy are the mainstream approaches in the treatment of nasopharyngeal carcinoma (NPC). These have been shown to effectively improve the outcome and reduce tumor recurrence. However, radiotherapy and chemotherapy resistance during the course of treatment has...
10:37
Cancer by Sfakianakis G.Alexandros
Metastatic squamous cell carcinoma (SCCA) anal cancer is relatively rare. With limited data, cisplatin plus 5-fluorouracil has traditionally been utilized in the first-line setting. Treatment beyond front-line cisplatin progression is not well defined. Epidermal growth factor receptor (EGFR) is highly...
10:37
Cancer by Sfakianakis G.Alexandros
The A33 protein, expressed in colorectal tumors, is a target for improving treatment of patients with colorectal cancer. Over the last decade, studies have tested anti-A33 antibody as a therapeutic agent for these patients. Preclinical results were promising, but clinical trials did not confirm positive...
10:37
Cancer by Sfakianakis G.Alexandros
Pancreatic cancer is among the leading causes of cancer death in the USA, with limited effective treatment options. A major contributor toward the formation and persistence of pancreatic cancer is the dysregulation of the hepatocyte growth factor (HGF)/Met (HGF receptor) and the macrophage-stimulating...
10:37
Cancer by Sfakianakis G.Alexandros
We have previously reported the cytotoxic effects of chalcone A1, derived from 1-naphthaldehyde, in leukemia cell lines. On the basis of these findings, the main aim of this study was to elucidate some of the molecular mechanisms involved in apoptosis induced by chalcone A1 toward K562 and Jurkat cells....
10:37
Cancer by Sfakianakis G.Alexandros
Preoperative chemoradiotherapy (CRT) is generally performed for locally advanced rectal cancer (LARC, cStage 2 or 3) to improve local disease control and patient survival. The pathological tumor response to CRT is a surrogate marker that is associated with oncological outcome. Thus, markers that predict...
10:37
Cancer by Sfakianakis G.Alexandros
Docetaxel-based chemotherapy has been recommended for advanced nasopharyngeal carcinoma (NPC). However, treatment failure often occurs because of acquired drug resistance. In this study, a docetaxel-resistant NPC cell line CNE-2R was established with increasing doses of docetaxel for more than 6 months....
10:37
Cancer by Sfakianakis G.Alexandros
The combination of daunorubicin and cytarabine is the cornerstone of induction therapy for acute myeloid leukemia (AML). Little data are available on the optimal chemotherapy regimen for patients with AML and advanced renal failure, with some authors recommending administration of reduced daunorubicin...
10:37
Cancer by Sfakianakis G.Alexandros
Bromodomain and extraterminal protein (BET) inhibitors suppress the expression of c-MYC. U266, a human myeloma cell line, expresses the MYCL gene, but not the c-MYC gene. Our aim was to analyse the antimyeloma activity of BET inhibitors on U266 cells. Two BET inhibitors, I-BET151 and JQ1, were tested....
10:37
Cancer by Sfakianakis G.Alexandros
No abstract available from Cancer via xlomafota13 on Inoreader http://ift.tt/2al82zX via IFTTT
10:26
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
No abstract available from Cancer via xlomafota13 on Inoreader http://ift.tt/2aE57o6
10:26
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
Although the same treatment strategy as used for small cell lung cancer, including second-line chemotherapy, is generally applied to metastatic neuroendocrine carcinoma (NEC) and mixed adenoneuroendocrine carcinoma (MANEC) of the gastrointestinal tract (GIT; GIT-NEC/MANEC), the efficacy of amrubicin...
10:26
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
T-lymphocytes genetically engineered with the chimeric antigen receptor (CAR-T) have shown great therapeutic potential in cancer treatment. A variety of preclinical researches and clinical trials of CAR-T therapy have been carried out to lay the foundation for future clinical application. In these researches,...
10:26
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
Evofosfamide, also formerly known as TH-302, is an investigational hypoxia-activated prodrug and is used to target cancerous cells under hypoxic conditions, which is a feature possessed by multiple solid tumors including pancreatic tumors. Gemcitabine, a cytotoxic agent, has for many years been the standard...
10:26
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
Ototoxicity continues to be a major dose-limiting side effect of cis-diamminedichloroplatinum(II) (cisplatin). With an ongoing need to develop pharmaceutical protection strategies for cisplatin’s ototoxicity, there is also a need to develop stable in-vivo mammalian models of cisplatin ototoxicity. The...
10:26
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
Radiotherapy and adjuvant cisplatin chemotherapy are the mainstream approaches in the treatment of nasopharyngeal carcinoma (NPC). These have been shown to effectively improve the outcome and reduce tumor recurrence. However, radiotherapy and chemotherapy resistance during the course of treatment has...
10:26
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
Metastatic squamous cell carcinoma (SCCA) anal cancer is relatively rare. With limited data, cisplatin plus 5-fluorouracil has traditionally been utilized in the first-line setting. Treatment beyond front-line cisplatin progression is not well defined. Epidermal growth factor receptor (EGFR) is highly...
10:26
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
Pancreatic cancer is among the leading causes of cancer death in the USA, with limited effective treatment options. A major contributor toward the formation and persistence of pancreatic cancer is the dysregulation of the hepatocyte growth factor (HGF)/Met (HGF receptor) and the macrophage-stimulating...
10:26
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
The A33 protein, expressed in colorectal tumors, is a target for improving treatment of patients with colorectal cancer. Over the last decade, studies have tested anti-A33 antibody as a therapeutic agent for these patients. Preclinical results were promising, but clinical trials did not confirm positive...
10:26
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
We have previously reported the cytotoxic effects of chalcone A1, derived from 1-naphthaldehyde, in leukemia cell lines. On the basis of these findings, the main aim of this study was to elucidate some of the molecular mechanisms involved in apoptosis induced by chalcone A1 toward K562 and Jurkat cells....
10:26
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
Preoperative chemoradiotherapy (CRT) is generally performed for locally advanced rectal cancer (LARC, cStage 2 or 3) to improve local disease control and patient survival. The pathological tumor response to CRT is a surrogate marker that is associated with oncological outcome. Thus, markers that predict...
10:26
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
Docetaxel-based chemotherapy has been recommended for advanced nasopharyngeal carcinoma (NPC). However, treatment failure often occurs because of acquired drug resistance. In this study, a docetaxel-resistant NPC cell line CNE-2R was established with increasing doses of docetaxel for more than 6 months....
10:26
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
The combination of daunorubicin and cytarabine is the cornerstone of induction therapy for acute myeloid leukemia (AML). Little data are available on the optimal chemotherapy regimen for patients with AML and advanced renal failure, with some authors recommending administration of reduced daunorubicin...
10:26
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
Bromodomain and extraterminal protein (BET) inhibitors suppress the expression of c-MYC. U266, a human myeloma cell line, expresses the MYCL gene, but not the c-MYC gene. Our aim was to analyse the antimyeloma activity of BET inhibitors on U266 cells. Two BET inhibitors, I-BET151 and JQ1, were tested....
10:26
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
No abstract available from Cancer via xlomafota13 on Inoreader http://ift.tt/2al82zX
10:26
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
No abstract available from #ORL via xlomafota13 on Inoreader http://ift.tt/2al6pSR
10:26
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
Purpose of review: Perforator flaps are increasingly being used to reconstruct head and neck defects. They offer several advantages over nonperforator-based flaps with lower donor site morbidity and a versatile range of reconstructive options. The anterolateral thigh flap is well established in the head...
09:56
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
No abstract available from NeuroSurgery via xlomafota13 on Inoreader http://ift.tt/2aDy8ki
09:56
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
No abstract available from NeuroSurgery via xlomafota13 on Inoreader http://ift.tt/2aFuDGW
09:56
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
No abstract available from NeuroSurgery via xlomafota13 on Inoreader http://ift.tt/2aDxEL6
09:56
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
Intracranial pressure (ICP) is the pressure inside the bony calvarium and can be affected by a variety of processes, such as intracranial masses and edema, obstruction or leakage of cerebrospinal fluid, and obstruction of venous outflow. This review focuses on the imaging of 2 important but less well...
09:56
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
No abstract available from NeuroSurgery via xlomafota13 on Inoreader http://ift.tt/2aDxFi8
09:56
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
BACKGROUND: Embolic protection devices are used during carotid artery stenting procedures to reduce risk of distal embolization. Although this is a standard procedural recommendation, no studies have shown superiority of these devices over unprotected stenting procedures. OBJECTIVE: To assess the...
09:56
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
A reference on drug metabolism and metabolite safety in the development phase, this book reviews the analytical techniques and experimental designs critical for metabolite studies. It features case studies of lessons learned and real world examples, along with regulatory perspectives from the US...
09:56
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
Background: Adoptive transfer of FOXP3+ regulatory T cells (Treg) offers a promising strategy to reduce damage to an allograft by the recipient’s immune system. Identification of cell surface markers sufficient to purify Treg expanded ex vivo to remove cellular contaminants requires optimisation. Furthermore,...
09:56
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
No abstract available from Allergy and Immunology via xlomafota13 on Inoreader http://ift.tt/2al4xtp
09:56
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
Background: The influence of preexisting donor-transmitted atherosclerosis (DA) on cardiac allograft vasculopathy (CAV) development remains unclear. Methods: We performed 3-dimensional intravascular ultrasound (3D-IVUS) analysis in 42 heart transplant (HTx) recipients at 2.1+/-0.9 months (baseline)...
09:56
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
Background: An increased percentage of peripheral transitional B cells producing IL-10 has been observed in patients tolerant to kidney allografts. In healthy volunteers, the balance between the CD40 and B cell receptor (BCR) signalling modulated IL-10 production by B cells, with stimulation via the...
09:56
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
No abstract available from Allergy and Immunology via xlomafota13 on Inoreader http://ift.tt/2akbCqT
09:56
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
In the setting of solid-organ transplantation, calcineurin inhibitor (CNI)-based therapy remains the cornerstone of immunosuppression. However, long-term use of CNIsis associated with some degree of nephrotoxicity. This has led to exploring the blockadeof some costimulation pathways as an efficient immunosuppressive...
09:56
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
Background: Elderly patients are the fastest growing group in need of renal transplantation. This study puts focus on renal transplant recipients in their eightieth year or older at time of engraftment. Is there evidence to support an absolute upper age limit for renal transplantation? Methods: Recipients...
09:56
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
During the last 20 years, waiting lists for renal transplantation (RT) have grown significantly older. However, elderly patients (ie >=65 years of age) are still more rarely referred or accepted to waiting lists and, if enlisted, have less chances of actually receiving a kidney allograft, than younger...
09:56
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
No abstract available from Allergy and Immunology via xlomafota13 on Inoreader http://ift.tt/2al4PjH
09:56
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
Background: In adult living donor liver transplantation (ALDLT), graft-to-recipient weight ratio (GRWR) of less than 0.8 is incomplete for predicting portal hypertension (>20 mmHg) after reperfusion. We aimed to identify preoperative factors contributing to PVP after reperfusion and to predict portal...
09:56
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
Repression of phosphoglycerate dehydrogenase sensitizes triple-negative breast cancer to doxorubicin
Abstract Purpose Approximately 70 % of triple-negative breast cancer (TNBC) cell lines are identified to upregulate phosphoglycerate dehydrogenase (PHGDH), which regulates the intracellular synthesis of serine and glycine, and promotes...
09:53
Medicine
No abstract availablehttp://ift.tt/2aDy8ki from #ENT-ORL via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2aFucw2 via IFTTT
09:53
Medicine
No abstract availablehttp://ift.tt/2aFuDGW from #ENT-ORL via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2aFudQG via IFTTT
09:53
Medicine
No abstract availablehttp://ift.tt/2aDxEL6 from #ENT-ORL via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2aDyaIW via IFTTT
09:53
Medicine
No abstract availablehttp://ift.tt/2aDxFi8 from #ENT-ORL via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2aFuqmX via IFTTT
09:53
Medicine
Intracranial pressure (ICP) is the pressure inside the bony calvarium and can be affected by a variety of processes, such as intracranial masses and edema, obstruction or leakage of cerebrospinal fluid, and obstruction of venous outflow. This review focuses on the imaging of 2 important but less well...
09:53
Medicine
BACKGROUND: Embolic protection devices are used during carotid artery stenting procedures to reduce risk of distal embolization. Although this is a standard procedural recommendation, no studies have shown superiority of these devices over unprotected stenting procedures. OBJECTIVE: To assess the periprocedural...
09:53
Medicine
Background: Adoptive transfer of FOXP3+ regulatory T cells (Treg) offers a promising strategy to reduce damage to an allograft by the recipient’s immune system. Identification of cell surface markers sufficient to purify Treg expanded ex vivo to remove cellular contaminants requires optimisation. Furthermore,...
09:53
Medicine
Background: An increased percentage of peripheral transitional B cells producing IL-10 has been observed in patients tolerant to kidney allografts. In healthy volunteers, the balance between the CD40 and B cell receptor (BCR) signalling modulated IL-10 production by B cells, with stimulation via the...
09:53
Medicine
No abstract available from #ENT via xlomafota13 on Inoreader http://ift.tt/2al4xtp via IFTTT from #ENT via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2aDxROj via IFTTT
09:53
Medicine
Background: The influence of preexisting donor-transmitted atherosclerosis (DA) on cardiac allograft vasculopathy (CAV) development remains unclear. Methods: We performed 3-dimensional intravascular ultrasound (3D-IVUS) analysis in 42 heart transplant (HTx) recipients at 2.1+/-0.9 months (baseline) and...
09:53
Medicine
No abstract available from #ENT via xlomafota13 on Inoreader http://ift.tt/2akbCqT via IFTTT from #ENT via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2aFv8k9 via IFTTT
09:53
Medicine
In the setting of solid-organ transplantation, calcineurin inhibitor (CNI)-based therapy remains the cornerstone of immunosuppression. However, long-term use of CNIsis associated with some degree of nephrotoxicity. This has led to exploring the blockadeof some costimulation pathways as an efficient immunosuppressive...
09:53
Medicine
Background: Elderly patients are the fastest growing group in need of renal transplantation. This study puts focus on renal transplant recipients in their eightieth year or older at time of engraftment. Is there evidence to support an absolute upper age limit for renal transplantation? Methods: Recipients...
09:53
Medicine
Publication date: December 2016Source:Current Opinion in Neurobiology, Volume 41 Author(s): Zhenyu Liu, Ali S Hamodi, Kara G Pratt The retinotectal circuit is the major component of the amphibian visual system. It is comprised of the retinal ganglion cells (RGCs) in the eye, which project their axons...
09:53
Medicine
No abstract availablehttp://ift.tt/2aDy8ki from #ENT via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2aFucw2 via IFTTT
09:53
Medicine
No abstract availablehttp://ift.tt/2aDxEL6 from #ENT via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2aDyaIW via IFTTT
09:53
Medicine
Intracranial pressure (ICP) is the pressure inside the bony calvarium and can be affected by a variety of processes, such as intracranial masses and edema, obstruction or leakage of cerebrospinal fluid, and obstruction of venous outflow. This review focuses on the imaging of 2 important but less well...
09:53
Medicine
No abstract availablehttp://ift.tt/2aFuDGW from #ENT via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2aFudQG via IFTTT
09:53
Medicine
No abstract availablehttp://ift.tt/2aDxFi8 from #ENT via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2aFuqmX via IFTTT
09:53
Medicine
BACKGROUND: Embolic protection devices are used during carotid artery stenting procedures to reduce risk of distal embolization. Although this is a standard procedural recommendation, no studies have shown superiority of these devices over unprotected stenting procedures. OBJECTIVE: To assess the periprocedural...
09:53
Allergy and Immunology by Alexandros G.Sfakianakis
Background: Adoptive transfer of FOXP3+ regulatory T cells (Treg) offers a promising strategy to reduce damage to an allograft by the recipient’s immune system. Identification of cell surface markers sufficient to purify Treg expanded ex vivo to remove cellular contaminants requires optimisation. Furthermore,...
09:53
Allergy and Immunology by Alexandros G.Sfakianakis
No abstract available from Allergy and Immunology via xlomafota13 on Inoreader http://ift.tt/2al4xtp via IFTTT
09:53
Allergy and Immunology by Alexandros G.Sfakianakis
Background: An increased percentage of peripheral transitional B cells producing IL-10 has been observed in patients tolerant to kidney allografts. In healthy volunteers, the balance between the CD40 and B cell receptor (BCR) signalling modulated IL-10 production by B cells, with stimulation via the...
09:53
Allergy and Immunology by Alexandros G.Sfakianakis
Background: The influence of preexisting donor-transmitted atherosclerosis (DA) on cardiac allograft vasculopathy (CAV) development remains unclear. Methods: We performed 3-dimensional intravascular ultrasound (3D-IVUS) analysis in 42 heart transplant (HTx) recipients at 2.1+/-0.9 months (baseline)...
09:53
Allergy and Immunology by Alexandros G.Sfakianakis
No abstract available from Allergy and Immunology via xlomafota13 on Inoreader http://ift.tt/2akbCqT via IFTTT
09:53
Allergy and Immunology by Alexandros G.Sfakianakis
In the setting of solid-organ transplantation, calcineurin inhibitor (CNI)-based therapy remains the cornerstone of immunosuppression. However, long-term use of CNIsis associated with some degree of nephrotoxicity. This has led to exploring the blockadeof some costimulation pathways as an efficient immunosuppressive...
09:53
Allergy and Immunology by Alexandros G.Sfakianakis
Background: In adult living donor liver transplantation (ALDLT), graft-to-recipient weight ratio (GRWR) of less than 0.8 is incomplete for predicting portal hypertension (>20 mmHg) after reperfusion. We aimed to identify preoperative factors contributing to PVP after reperfusion and to predict portal...
09:53
Allergy and Immunology by Alexandros G.Sfakianakis
During the last 20 years, waiting lists for renal transplantation (RT) have grown significantly older. However, elderly patients (ie >=65 years of age) are still more rarely referred or accepted to waiting lists and, if enlisted, have less chances of actually receiving a kidney allograft, than younger...
09:53
Allergy and Immunology by Alexandros G.Sfakianakis
Background: Elderly patients are the fastest growing group in need of renal transplantation. This study puts focus on renal transplant recipients in their eightieth year or older at time of engraftment. Is there evidence to support an absolute upper age limit for renal transplantation? Methods: Recipients...
09:53
Allergy and Immunology by Alexandros G.Sfakianakis
No abstract available from Allergy and Immunology via xlomafota13 on Inoreader http://ift.tt/2al4PjH via IFTTT
09:37
Cancer by Sfakianakis G.Alexandros
Repression of phosphoglycerate dehydrogenase sensitizes triple-negative breast cancer to doxorubicin
Abstract Purpose Approximately 70 % of triple-negative breast cancer (TNBC) cell lines are identified to upregulate phosphoglycerate dehydrogenase (PHGDH), which regulates the intracellular synthesis of serine and glycine, and promotes...
09:37
Cancer by Sfakianakis G.Alexandros
Publication date: Available online 29 July 2016Source:Cancer Treatment Reviews Author(s): Matteo Lambertini, Luigi Santoro, Lucia Del Mastro, Bastien Nguyen, Luca Livraghi, Donatella Ugolini, Fedro A. Peccatori, Hatem A. Azim JrBackgroundBreast cancer is composed of distinct subtypes...
09:37
Cancer by Sfakianakis G.Alexandros
Publication date: Available online 29 July 2016Source:Cancer Treatment Reviews Author(s): Tania Fleitas, Maider Ibarrola-Villava, Gloria Ribas, Andrés CervantesThis article will review the impact of the recently developed MassARRAY technology on our understanding of cancer biology and treatment....
09:25
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
Publication date: Available online 29 July 2016Source:Cancer Treatment Reviews Author(s): Matteo Lambertini, Luigi Santoro, Lucia Del Mastro, Bastien Nguyen, Luca Livraghi, Donatella Ugolini, Fedro A. Peccatori, Hatem A. Azim JrBackgroundBreast cancer is composed of distinct subtypes...
09:25
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
Publication date: Available online 29 July 2016Source:Cancer Treatment Reviews Author(s): Tania Fleitas, Maider Ibarrola-Villava, Gloria Ribas, Andrés CervantesThis article will review the impact of the recently developed MassARRAY technology on our understanding of cancer biology and treatment....
09:25
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
Bruxism is a repetitive jaw-muscle activity characterized by clenching or grinding of the teeth and/or bracing or thrusting of the mandible. Recent advances have clarified the relationship between gastroesophageal reflux and sleep bruxism (SB). However, the influence of pharmacological elimination of...
09:25
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
It is well known that exposure to maternal separation (MS) in early life causes plastic changes in the nervous system in adulthood, occasionally resulting in ubiquitous chronic pain. However, the pathogenic mechanisms of pain hypersensitivity remain unclear. Here, the authors examined the involvement...
09:23
Medicine
Background: Although patients with acute optic neuritis (ON) recover high-contrast visual acuity (HCVA) to 20/40 or better in 95% of affected eyes, patients with a history of ON continue to note subjective abnormalities of vision. Furthermore, substantial and permanent thinning of the retinal nerve fiber...
09:23
Medicine
In Rechargeable Wireless Sensor Networks (R-WSNs), in order to achieve the maximum data collection rate it is critical that sensors operate in very low duty cycles because of the sporadic availability of energy. A sensor has to stay in a dormant state in most of the time in order to recharge the battery...
09:23
Medicine
The profits of the ESCO (Energy Services Company) and EU (Energy Using Organization) in the EPCP (energy performance contracting project) rely on the signing of the shared savings contract and the successful operation of the project, and the probability of the project’s success is decided by the complementary...
09:23
Medicine
Spinal Muscular Atrophy (SMA) is a neuromuscular disease caused by mutations in the Survival Motor Neuron 1 gene, resulting in very low levels of functional Survival of Motor Neuron (SMN) protein. SMA human induced Pluripotent Stem Cells (hiPSCs) represent a useful and valid model for the study of the...
09:23
Medicine
The identification accuracy of dynamic characteristics coefficients is difficult to guarantee because of the errors of the measurement system itself. A novel dynamic calibration method of measurement system for dynamic characteristics coefficients is proposed in this paper to eliminate the errors of...
09:23
Medicine
This study was conducted to investigate the effect of the vascular endothelial growth factor (VEGF) and fibroblast growth factor 2 (FGF2) on revascularization, survival, and oocyte quality of cryopreserved, subcutaneously-transplanted mouse ovarian tissue. Autologous subcutaneous transplantation of vitrified-thawed...
09:23
Medicine
The FT/TFL1 gene family controls important aspects of plant development: MFT -like genes affect germination, TFL1 -like genes act as floral inhibitors, FT -like genes are floral activators. Gene duplications produced paralogs with modified functions required by the specific lifestyles of various angiosperm...
09:23
Medicine
The minichromosome maintenance (MCM) complex is the conserved helicase motor of the eukaryotic replication fork. Mutations in the Mcm4 subunit are associated with replication stress and double strand breaks in multiple systems. In this work we characterize a new temperature sensitive allele of Schizosaccharomyces...
09:23
Medicine
It is well known that exposure to maternal separation (MS) in early life causes plastic changes in the nervous system in adulthood, occasionally resulting in ubiquitous chronic pain. However, the pathogenic mechanisms of pain hypersensitivity remain unclear. Here, the authors examined the involvement...
09:23
Medicine
The Cell Wall Integrity (CWI) pathway is the primary signaling cascade that controls the de novo synthesis of the fungal cell wall and in Saccharomyces cerevisiae, this event is highly dependent on the RLM1 transcription factor. Here, we investigated the function of RlmA in the fungal pathogen Aspergillus...
09:23
Medicine
The FT/TFL1 gene family controls important aspects of plant development: MFT -like genes affect germination, TFL1 -like genes act as floral inhibitors, FT -like genes are floral activators. Gene duplications produced paralogs with modified functions required by the specific lifestyles of various angiosperm...
09:23
Medicine
The minichromosome maintenance (MCM) complex is the conserved helicase motor of the eukaryotic replication fork. Mutations in the Mcm4 subunit are associated with replication stress and double strand breaks in multiple systems. In this work we characterize a new temperature sensitive allele of Schizosaccharomyces...
09:23
Medicine
Background: Although patients with acute optic neuritis (ON) recover high-contrast visual acuity (HCVA) to 20/40 or better in 95% of affected eyes, patients with a history of ON continue to note subjective abnormalities of vision. Furthermore, substantial and permanent thinning of the retinal nerve fiber...
09:23
Medicine
Abstract Growing evidence suggests that deregulation of signalling elements of Notch and mammalian target of rapamycin (mTOR) pathways contribute to tumorigenesis. These signals play important roles in cellular functions and malignancies. Their tumorigenic role in T-cell acute lymphoblastic leukaemia...
09:23
Medicine
http://ift.tt/2akZZDf from #MedJournals via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2aDZS7X via IFTTT
09:23
Medicine
Abstract Mutation analysis of epidermal growth factor receptor (EGFR) gene is essential for treatment selection in non-small cell lung cancer (NSCLC). Analysis is usually performed in tumor samples. We evaluated the clinical utility of EGFR analysis in plasma cell-free DNA (cfDNA) from patients under...
09:23
Medicine
Abstract Mutation analysis of epidermal growth factor receptor (EGFR) gene is essential for treatment selection in non-small cell lung cancer (NSCLC). Analysis is usually performed in tumor samples. We evaluated the clinical utility of EGFR analysis in plasma cell-free DNA (cfDNA)...
09:23
Medicine
Abstract Growing evidence suggests that deregulation of signalling elements of Notch and mammalian target of rapamycin (mTOR) pathways contribute to tumorigenesis. These signals play important roles in cellular functions and malignancies. Their tumorigenic role in T-cell acute lymphoblastic...
09:23
Medicine
Both IL-7 and IL-15 have become important candidate immunomodulators for cancer treatment. However, IL-7 or IL-15 used alone suffers from shortcomings, such as short serum half-life and limited antitumor effect. We have cloned and expressed a recombinant ® IL-7/IL-15 fusion protein in which IL-7 and...
09:23
Medicine
It is well known that exposure to maternal separation (MS) in early life causes plastic changes in the nervous system in adulthood, occasionally resulting in ubiquitous chronic pain. However, the pathogenic mechanisms of pain hypersensitivity remain unclear. Here, the authors examined the involvement...
09:21
THERAPY MEDICINE BY SFAKIANAKIS G.ALEXANDROS
Repression of phosphoglycerate dehydrogenase sensitizes triple-negative breast cancer to doxorubicin
Abstract Purpose Approximately 70 % of triple-negative breast cancer (TNBC) cell lines are identified to upregulate phosphoglycerate dehydrogenase (PHGDH), which regulates the intracellular synthesis of serine and glycine, and promotes...
09:06
Cancer by Sfakianakis G.Alexandros
Abstract. The catalytically deficient ERBB3 strongly synergizes with the receptor tyrosine kinase ERBB2, and elevated levels represent an overall risk factor for unfavorable disease outcomes in breast cancer. Although itself not a target of pan ERBB kinase inhibitors, it contributes to resistance in...
09:06
Cancer by Sfakianakis G.Alexandros
Both IL-7 and IL-15 have become important candidate immunomodulators for cancer treatment. However, IL-7 or IL-15 used alone suffers from shortcomings, such as short serum half-life and limited antitumor effect. We have cloned and expressed a recombinant ® IL-7/IL-15 fusion protein in which IL-7 and...
09:06
Cancer by Sfakianakis G.Alexandros
Malignant gliomas exhibit a high level of intrinsic and acquired drug resistance and have a dismal prognosis. First and second line therapeutics for glioblastomas are alkylating agents, including the chloroethylating nitrosoureas (CNUs) lomustine, nimustine, fotemustine and carmustine. These agents target...
09:06
Cancer by Sfakianakis G.Alexandros
A typical obstacle to cancer therapy is the limited distribution of low-molecular weight anti-cancer drugs within the carcinoma tissue. In experimental carcinoma, Imatinib (STI571) increases efficacy of synchronized chemotherapy, reduces tumor interstitial fluid pressure and increases interstitial fluid...
09:06
Cancer by Sfakianakis G.Alexandros
The c-Myc gene encodes an oncoprotein transcription factor which is frequently up-regulated in almost all cancer types, and is the subject of intense investigation for management of cancer because of its pleiotropic effects controlling a spectrum of cellular functions. However, due of its non-enzymatic...
09:06
Cancer by Sfakianakis G.Alexandros
Resistance to radiotherapy due to insufficient cancer cell death is a significant cause of treatment failure in non-small cell lung cancer (NSCLC). The endogenous caspase-8 inhibitor, FLIP, is a critical regulator of cell death that is frequently overexpressed in NSCLC and is an established inhibitor...
09:06
Cancer by Sfakianakis G.Alexandros
CNDAC (2’-C-cyano-2’-deoxy-1-β-D-arabino-pentofuranosyl-cytosine, DFP10917) and its orally bioavailable prodrug, sapacitabine, are undergoing clinical trials for hematological malignancies and solid tumors. The unique action mechanism of inducing DNA strand breaks distinguishes CNDAC from other deoxycytidine...
09:06
Cancer by Sfakianakis G.Alexandros
Repression of phosphoglycerate dehydrogenase sensitizes triple-negative breast cancer to doxorubicin
Abstract Purpose Approximately 70 % of triple-negative breast cancer (TNBC) cell lines are identified to upregulate phosphoglycerate dehydrogenase (PHGDH), which regulates the intracellular synthesis of serine and glycine, and promotes...
09:06
Cancer by Sfakianakis G.Alexandros
from Cancer via xlomafota13 on Inoreader http://ift.tt/2akZZDf via IFTTT
08:55
Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolao
Abstract Plasticity of the axon initial segment (AIS) is a newly discovered type of structural plasticity that regulates cell excitability. AIS plasticity has been reported to happen during normal development of neocortex and also in a few pathological conditions involving disruption of the inhibition/excitation...
08:55
Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolao
Abstract Early chronic stress has enduring implications for physical and mental health outcomes. Hair cortisol concentration (HCC) has emerged as a marker of cumulative cortisol exposure, yet HCC in infants is not well understood. We examined how infant HCC relates to widely used basal salivary cortisol...
08:54
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
Malignant gliomas exhibit a high level of intrinsic and acquired drug resistance and have a dismal prognosis. First and second line therapeutics for glioblastomas are alkylating agents, including the chloroethylating nitrosoureas (CNUs) lomustine, nimustine, fotemustine and carmustine. These agents target...
08:54
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
Abstract. The catalytically deficient ERBB3 strongly synergizes with the receptor tyrosine kinase ERBB2, and elevated levels represent an overall risk factor for unfavorable disease outcomes in breast cancer. Although itself not a target of pan ERBB kinase inhibitors, it contributes to resistance in...
08:54
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
A typical obstacle to cancer therapy is the limited distribution of low-molecular weight anti-cancer drugs within the carcinoma tissue. In experimental carcinoma, Imatinib (STI571) increases efficacy of synchronized chemotherapy, reduces tumor interstitial fluid pressure and increases interstitial fluid...
08:54
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
Both IL-7 and IL-15 have become important candidate immunomodulators for cancer treatment. However, IL-7 or IL-15 used alone suffers from shortcomings, such as short serum half-life and limited antitumor effect. We have cloned and expressed a recombinant ® IL-7/IL-15 fusion protein in which IL-7 and...
08:54
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
The c-Myc gene encodes an oncoprotein transcription factor which is frequently up-regulated in almost all cancer types, and is the subject of intense investigation for management of cancer because of its pleiotropic effects controlling a spectrum of cellular functions. However, due of its non-enzymatic...
08:54
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
Resistance to radiotherapy due to insufficient cancer cell death is a significant cause of treatment failure in non-small cell lung cancer (NSCLC). The endogenous caspase-8 inhibitor, FLIP, is a critical regulator of cell death that is frequently overexpressed in NSCLC and is an established inhibitor...
08:54
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
CNDAC (2’-C-cyano-2’-deoxy-1-β-D-arabino-pentofuranosyl-cytosine, DFP10917) and its orally bioavailable prodrug, sapacitabine, are undergoing clinical trials for hematological malignancies and solid tumors. The unique action mechanism of inducing DNA strand breaks distinguishes CNDAC from other deoxycytidine...
08:54
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
Repression of phosphoglycerate dehydrogenase sensitizes triple-negative breast cancer to doxorubicin
Abstract Purpose Approximately 70 % of triple-negative breast cancer (TNBC) cell lines are identified to upregulate phosphoglycerate dehydrogenase (PHGDH), which regulates the intracellular synthesis of serine and glycine, and promotes...
08:54
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
from Cancer via xlomafota13 on Inoreader http://ift.tt/2akZZDf
08:54
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
Repression of phosphoglycerate dehydrogenase sensitizes triple-negative breast cancer to doxorubicin
Abstract Purpose Approximately 70 % of triple-negative breast cancer (TNBC) cell lines are identified to upregulate phosphoglycerate dehydrogenase (PHGDH), which regulates the intracellular synthesis of serine and glycine, and promotes...
08:54
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
Both IL-7 and IL-15 have become important candidate immunomodulators for cancer treatment. However, IL-7 or IL-15 used alone suffers from shortcomings, such as short serum half-life and limited antitumor effect. We have cloned and expressed a recombinant ® IL-7/IL-15 fusion protein in which IL-7 and...
08:53
Medicine
Ribosome-inactivating proteins have been isolated from Trichosanthes kirilowii root tubers and seeds, including trichosanthin, karasurin and T 33 from root tubers and trichosanthrip, trichokirin, alpha-kirilowin, beta-kirilowin and trichoanguin from seeds. The aforementioned proteins show structural...
08:53
Medicine
It is high time now to discover novel drugs due to the increasing rate of drug resistance by the pathogen organisms and target cells as well as the dependence or tolerance of the body towards the drug. As it is obvious that significant numbers of the modern day pharmaceuticals are derived from natural...
08:53
Medicine
Both IL-7 and IL-15 have become important candidate immunomodulators for cancer treatment. However, IL-7 or IL-15 used alone suffers from shortcomings, such as short serum half-life and limited antitumor effect. We have cloned and expressed a recombinant ® IL-7/IL-15 fusion protein in which IL-7 and...
08:53
Medicine
Malignant gliomas exhibit a high level of intrinsic and acquired drug resistance and have a dismal prognosis. First and second line therapeutics for glioblastomas are alkylating agents, including the chloroethylating nitrosoureas (CNUs) lomustine, nimustine, fotemustine and carmustine. These agents target...
08:53
Medicine
Both IL-7 and IL-15 have become important candidate immunomodulators for cancer treatment. However, IL-7 or IL-15 used alone suffers from shortcomings, such as short serum half-life and limited antitumor effect. We have cloned and expressed a recombinant ® IL-7/IL-15 fusion protein in which IL-7 and...
08:53
Medicine
Both IL-7 and IL-15 have become important candidate immunomodulators for cancer treatment. However, IL-7 or IL-15 used alone suffers from shortcomings, such as short serum half-life and limited antitumor effect. We have cloned and expressed a recombinant ® IL-7/IL-15 fusion protein in which IL-7 and...
08:53
Medicine
Both IL-7 and IL-15 have become important candidate immunomodulators for cancer treatment. However, IL-7 or IL-15 used alone suffers from shortcomings, such as short serum half-life and limited antitumor effect. We have cloned and expressed a recombinant ® IL-7/IL-15 fusion protein in which IL-7 and...
08:53
Medicine
Both IL-7 and IL-15 have become important candidate immunomodulators for cancer treatment. However, IL-7 or IL-15 used alone suffers from shortcomings, such as short serum half-life and limited antitumor effect. We have cloned and expressed a recombinant ® IL-7/IL-15 fusion protein in which IL-7 and...
08:53
Medicine
A typical obstacle to cancer therapy is the limited distribution of low-molecular weight anti-cancer drugs within the carcinoma tissue. In experimental carcinoma, Imatinib (STI571) increases efficacy of synchronized chemotherapy, reduces tumor interstitial fluid pressure and increases interstitial fluid...
08:53
Medicine
Resistance to radiotherapy due to insufficient cancer cell death is a significant cause of treatment failure in non-small cell lung cancer (NSCLC). The endogenous caspase-8 inhibitor, FLIP, is a critical regulator of cell death that is frequently overexpressed in NSCLC and is an established inhibitor...
08:53
Medicine
The c-Myc gene encodes an oncoprotein transcription factor which is frequently up-regulated in almost all cancer types, and is the subject of intense investigation for management of cancer because of its pleiotropic effects controlling a spectrum of cellular functions. However, due of its non-enzymatic...
08:53
Medicine
Repression of phosphoglycerate dehydrogenase sensitizes triple-negative breast cancer to doxorubicin
Abstract Purpose Approximately 70 % of triple-negative breast cancer (TNBC) cell lines are identified to upregulate phosphoglycerate dehydrogenase (PHGDH), which regulates the intracellular synthesis of serine and glycine, and promotes tumor growth. In this work, the impact of this pathway on doxorubicin...
08:53
Medicine
CNDAC (2’-C-cyano-2’-deoxy-1-β-D-arabino-pentofuranosyl-cytosine, DFP10917) and its orally bioavailable prodrug, sapacitabine, are undergoing clinical trials for hematological malignancies and solid tumors. The unique action mechanism of inducing DNA strand breaks distinguishes CNDAC from other deoxycytidine...
08:53
Medicine
from Cancer via ola Kala on Inoreader http://ift.tt/2akZZDf via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2axS3hO via IFTTT
08:53
Medicine
Both IL-7 and IL-15 have become important candidate immunomodulators for cancer treatment. However, IL-7 or IL-15 used alone suffers from shortcomings, such as short serum half-life and limited antitumor effect. We have cloned and expressed a recombinant ® IL-7/IL-15 fusion protein in which IL-7 and...
08:53
Medicine
Ribosome-inactivating proteins have been isolated from Trichosanthes kirilowii root tubers and seeds, including trichosanthin, karasurin and T 33 from root tubers and trichosanthrip, trichokirin, alpha-kirilowin, beta-kirilowin and trichoanguin from seeds. The aforementioned proteins show structural...
08:53
Medicine
It is high time now to discover novel drugs due to the increasing rate of drug resistance by the pathogen organisms and target cells as well as the dependence or tolerance of the body towards the drug. As it is obvious that significant numbers of the modern day pharmaceuticals are derived from natural...
08:53
Medicine
Both IL-7 and IL-15 have become important candidate immunomodulators for cancer treatment. However, IL-7 or IL-15 used alone suffers from shortcomings, such as short serum half-life and limited antitumor effect. We have cloned and expressed a recombinant ® IL-7/IL-15 fusion protein in which IL-7 and...
08:53
Medicine
Abstract Mutation analysis of epidermal growth factor receptor (EGFR) gene is essential for treatment selection in non-small cell lung cancer (NSCLC). Analysis is usually performed in tumor samples. We evaluated the clinical utility of EGFR analysis in plasma cell-free DNA (cfDNA) from patients under...
08:53
Medicine
Abstract Growing evidence suggests that deregulation of signalling elements of Notch and mammalian target of rapamycin (mTOR) pathways contribute to tumorigenesis. These signals play important roles in cellular functions and malignancies. Their tumorigenic role in T-cell acute lymphoblastic leukaemia...
08:36
Cancer by Sfakianakis G.Alexandros
from Cancer via xlomafota13 on Inoreader http://ift.tt/2akZZDf via IFTTT
08:36
Cancer by Sfakianakis G.Alexandros
CDK5 suppression promotes CD4+ T cell–mediated antitumor immunity in medulloblastoma. from Cancer via xlomafota13 on Inoreader http://ift.tt/2ab8GgG via IFTTT
08:36
Cancer by Sfakianakis G.Alexandros
SGK1 drives resistance to PI3Kα inhibitors in PI3KCA mutant breast cancer. from Cancer via xlomafota13 on Inoreader http://ift.tt/2anzJse via IFTTT
08:36
Cancer by Sfakianakis G.Alexandros
Replication fork protection reduces chemosensitivity in BRCA-deficient cells without restoring HR. from Cancer via xlomafota13 on Inoreader http://ift.tt/2ab8zBE via IFTTT
08:36
Cancer by Sfakianakis G.Alexandros
Combined loss of DNMT3A and TET2 in HSCs promotes lineage-specific transcription factor expression. from Cancer via xlomafota13 on Inoreader http://ift.tt/2anAdPi via IFTTT
08:36
Cancer by Sfakianakis G.Alexandros
Ceritinib Exhibits Responses in Patients with ALK-Rearranged NSCLC [Research Watch: Clinical Trials]
Ceritinib produces durable responses in heavily pretreated patients who progressed on crizotinib. from Cancer via xlomafota13 on Inoreader http://ift.tt/2ab8ZYT via IFTTT
08:36
Cancer by Sfakianakis G.Alexandros
Future Oncology Ahead of Print. from Cancer via xlomafota13 on Inoreader http://ift.tt/2alJB3c via IFTTT
08:36
Cancer by Sfakianakis G.Alexandros
Related ArticlesThyroid Ophthalmopathy, Dermopathy, and Acropachy. N Engl J Med. 2016 Jul 21;375(3):261 Authors: Guerrero C, Pittelkow MR Abstract A 56-year-old man was referred to a dermatologist for assessment of the progression of his thyroid dermopathy....
08:36
Cancer by Sfakianakis G.Alexandros
Related ArticlesThyroid Ophthalmopathy, Dermopathy, and Acropachy. N Engl J Med. 2016 Jul 21;375(3):261 Authors: Guerrero C, Pittelkow MR Abstract A 56-year-old man was referred to a dermatologist for assessment of the progression of his thyroid dermopathy....
08:24
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
from Cancer via xlomafota13 on Inoreader http://ift.tt/2akZZDf
08:24
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
Summary BackgroundPlatelet-rich plasma (PRP) is considered as a growing modality for tissue regeneration and a developing research area for clinicians and researchers. PRP injection treatment provides supraphysiological concentrations of growth factors that may help in accelerated tissue remodeling...
08:24
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
Summary Chemical relaxers are products marketed to straighten the hair and have been principally used by African Americans since the early twentieth century. They contain alkaline agents that break and reform hydrogen and disulfide bonds, leaving hair permanently straightened. Relaxers cause loss of...
08:24
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
Summary ObjectiveThe purpose of the research was to evaluate skin elasticity and reduction in the aging eye area after using a nonablative radiofrequency treatment. Material and methodsThis study included 23 patients, aged 34–58 years with Fitzpatrick skin type II and III. They received five treatment...
08:24
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
CDK5 suppression promotes CD4+ T cell–mediated antitumor immunity in medulloblastoma. from Cancer via xlomafota13 on Inoreader http://ift.tt/2ab8GgG
08:24
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
SGK1 drives resistance to PI3Kα inhibitors in PI3KCA mutant breast cancer. from Cancer via xlomafota13 on Inoreader http://ift.tt/2anzJse
08:24
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
Replication fork protection reduces chemosensitivity in BRCA-deficient cells without restoring HR. from Cancer via xlomafota13 on Inoreader http://ift.tt/2ab8zBE
08:24
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
Combined loss of DNMT3A and TET2 in HSCs promotes lineage-specific transcription factor expression. from Cancer via xlomafota13 on Inoreader http://ift.tt/2anAdPi
08:24
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
Ceritinib Exhibits Responses in Patients with ALK-Rearranged NSCLC [Research Watch: Clinical Trials]
Ceritinib produces durable responses in heavily pretreated patients who progressed on crizotinib. from Cancer via xlomafota13 on Inoreader http://ift.tt/2ab8ZYT
08:24
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
Future Oncology Ahead of Print. from Cancer via xlomafota13 on Inoreader http://ift.tt/2alJB3c
08:23
Medicine
Summary Background Platelet-rich plasma (PRP) is considered as a growing modality for tissue regeneration and a developing research area for clinicians and researchers. PRP injection treatment provides supraphysiological concentrations of growth factors that may help in accelerated tissue remodeling...
08:23
Medicine
AbstractObjectivesThis study investigated chewing function in elderly individuals with Alzheimer’s disease (AD) and correlated chewing function with cognitive status.Materials and methodsSixteen elderly individuals with mild AD (mean age 76.7 ± 6.3 years; 8 men, 8 women) and 16 age and gender-matched...
08:23
Medicine
Summary Objective The purpose of the research was to evaluate skin elasticity and reduction in the aging eye area after using a nonablative radiofrequency treatment. Material and methods This study included 23 patients, aged 34–58 years with Fitzpatrick skin type II and III. They received...
08:23
Medicine
Summary Chemical relaxers are products marketed to straighten the hair and have been principally used by African Americans since the early twentieth century. They contain alkaline agents that break and reform hydrogen and disulfide bonds, leaving hair permanently straightened. Relaxers cause loss...
08:23
Medicine
AbstractObjectivesThis study investigated chewing function in elderly individuals with Alzheimer’s disease (AD) and correlated chewing function with cognitive status.Materials and methodsSixteen elderly individuals with mild AD (mean age 76.7 ± 6.3 years; 8 men, 8 women) and 16 age and gender-matched...
08:23
Medicine
Summary Background Platelet-rich plasma (PRP) is considered as a growing modality for tissue regeneration and a developing research area for clinicians and researchers. PRP injection treatment provides supraphysiological concentrations of growth factors that may help in accelerated tissue remodeling...
08:23
Medicine
Summary Objective The purpose of the research was to evaluate skin elasticity and reduction in the aging eye area after using a nonablative radiofrequency treatment. Material and methods This study included 23 patients, aged 34–58 years with Fitzpatrick skin type II and III. They received...
08:23
Medicine
Summary Chemical relaxers are products marketed to straighten the hair and have been principally used by African Americans since the early twentieth century. They contain alkaline agents that break and reform hydrogen and disulfide bonds, leaving hair permanently straightened. Relaxers cause loss...
08:23
Medicine
Thyroid-like follicular carcinoma of the kidney (TLFCK) is a rare but emerging renal neoplasm that morphologically mimics follicular carcinoma of the thyroid but lacks immunohistochemical expression of thyroid markers such as TTF-1 and thyroglobulin. Here, a case of an incidentally discovered TLFCK in...
08:23
Medicine
Abstract Previous data suggest that patients enrolled on clinical trials for treatment of cancer have better overall survival than patients who do not enroll; however, short-term outcomes relative to trial enrollment and corresponding mediators have not been assessed. A cohort of pediatric patients...
08:23
Medicine
from #Oncology via alexandrossfakianakis on Inoreader http://ift.tt/2ajbL41 via IFTTThttp://ift.tt/2alNZ2g from #MedJournals via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2ak5M8Y via IFTTT
08:23
Medicine
Abstract Previous data suggest that patients enrolled on clinical trials for treatment of cancer have better overall survival than patients who do not enroll; however, short-term outcomes relative to trial enrollment and corresponding mediators have not been assessed. A cohort of pediatric patients...
08:23
Medicine
The equilibrium linking the intestinal microbiota, the intestinal epithelium, and the host immune system establishes host health and homeostasis, with perturbations of this balance resulting in chronic inflammatory and autoimmune immunopathologies. The mutualistic symbiosis between gut microbiota and...
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