Αρχειοθήκη ιστολογίου

Αναζήτηση αυτού του ιστολογίου

Σάββατο 30 Ιουλίου 2016

Oncology,Physiology,Occupational and Environmental Medicine

Oncology
Correlation of cognitive and masticatory function in Alzheimer’s disease
Abstract Objectives This study investigated chewing function in elderly individuals with Alzheimer’s disease (AD) and correlated chewing function with cognitive status. Materials and methods Sixteen elderly individuals with mild AD (mean age 76.7 ± 6.3 years; 8 men, 8 women) and 16 age and gender-matched...

Oncology
Predicting a pathological complete response in rectal cancer
No abstract availablehttp://ift.tt/2aE57o6
Oncology
Paralleled comparison of vectors for the generation of CAR-T cells
T-lymphocytes genetically engineered with the chimeric antigen receptor (CAR-T) have shown great therapeutic potential in cancer treatment. A variety of preclinical researches and clinical trials of CAR-T therapy have been carried out to lay the foundation for future clinical application. In these researches,...
Oncology
Amrubicin in patients with platinum-refractory metastatic neuroendocrine carcinoma and mixed adenoneuroendocrine carcinoma of the gastrointestinal tract
Although the same treatment strategy as used for small cell lung cancer, including second-line chemotherapy, is generally applied to metastatic neuroendocrine carcinoma (NEC) and mixed adenoneuroendocrine carcinoma (MANEC) of the gastrointestinal tract (GIT; GIT-NEC/MANEC), the efficacy of amrubicin...
Oncology
Knockdown of GRP78 enhances cell death by cisplatin and radiotherapy in nasopharyngeal cells
Radiotherapy and adjuvant cisplatin chemotherapy are the mainstream approaches in the treatment of nasopharyngeal carcinoma (NPC). These have been shown to effectively improve the outcome and reduce tumor recurrence. However, radiotherapy and chemotherapy resistance during the course of treatment has...
Oncology
Ototoxicity of 12 mg/kg cisplatin in the Fischer 344/NHsd rat using multiple dosing strategies
Ototoxicity continues to be a major dose-limiting side effect of cis-diamminedichloroplatinum(II) (cisplatin). With an ongoing need to develop pharmaceutical protection strategies for cisplatin’s ototoxicity, there is also a need to develop stable in-vivo mammalian models of cisplatin ototoxicity. The...
Oncology
Evofosfamide, a new horizon in the treatment of pancreatic cancer
Evofosfamide, also formerly known as TH-302, is an investigational hypoxia-activated prodrug and is used to target cancerous cells under hypoxic conditions, which is a feature possessed by multiple solid tumors including pancreatic tumors. Gemcitabine, a cytotoxic agent, has for many years been the standard...
Oncology
Heterogeneous expression of A33 in colorectal cancer: possible explanation for A33 antibody treatment failure
The A33 protein, expressed in colorectal tumors, is a target for improving treatment of patients with colorectal cancer. Over the last decade, studies have tested anti-A33 antibody as a therapeutic agent for these patients. Preclinical results were promising, but clinical trials did not confirm positive...
Oncology
Epidermal growth factor receptor inhibition in metastatic anal cancer
Metastatic squamous cell carcinoma (SCCA) anal cancer is relatively rare. With limited data, cisplatin plus 5-fluorouracil has traditionally been utilized in the first-line setting. Treatment beyond front-line cisplatin progression is not well defined. Epidermal growth factor receptor (EGFR) is highly...
Oncology
Analogs of the hepatocyte growth factor and macrophage-stimulating protein hinge regions act as Met and Ron dual inhibitors in pancreatic cancer cells
Pancreatic cancer is among the leading causes of cancer death in the USA, with limited effective treatment options. A major contributor toward the formation and persistence of pancreatic cancer is the dysregulation of the hepatocyte growth factor (HGF)/Met (HGF receptor) and the macrophage-stimulating...
Oncology
Seven low-mass ions in pretreatment serum as potential predictive markers of the chemoradiotherapy response of rectal cancer
Preoperative chemoradiotherapy (CRT) is generally performed for locally advanced rectal cancer (LARC, cStage 2 or 3) to improve local disease control and patient survival. The pathological tumor response to CRT is a surrogate marker that is associated with oncological outcome. Thus, markers that predict...
Oncology
Investigation of cellular mechanisms involved in apoptosis induced by a synthetic naphthylchalcone in acute leukemia cell lines
We have previously reported the cytotoxic effects of chalcone A1, derived from 1-naphthaldehyde, in leukemia cell lines. On the basis of these findings, the main aim of this study was to elucidate some of the molecular mechanisms involved in apoptosis induced by chalcone A1 toward K562 and Jurkat cells....
Oncology
Cytosine arabinoside and daunorubicin induction therapy in a patient with acute myeloid leukemia on chronic hemodialysis
The combination of daunorubicin and cytarabine is the cornerstone of induction therapy for acute myeloid leukemia (AML). Little data are available on the optimal chemotherapy regimen for patients with AML and advanced renal failure, with some authors recommending administration of reduced daunorubicin...
Oncology
Proteomic analysis of docetaxel resistance in human nasopharyngeal carcinoma cells using the two-dimensional gel electrophoresis method
Docetaxel-based chemotherapy has been recommended for advanced nasopharyngeal carcinoma (NPC). However, treatment failure often occurs because of acquired drug resistance. In this study, a docetaxel-resistant NPC cell line CNE-2R was established with increasing doses of docetaxel for more than 6 months....
Oncology
Antimyeloma activity of bromodomain inhibitors on the human myeloma cell line U266 by downregulation of MYCL
Bromodomain and extraterminal protein (BET) inhibitors suppress the expression of c-MYC. U266, a human myeloma cell line, expresses the MYCL gene, but not the c-MYC gene. Our aim was to analyse the antimyeloma activity of BET inhibitors on U266 cells. Two BET inhibitors, I-BET151 and JQ1, were tested....
Oncology
Apatinib in metastatic gastric cancer: can paclitaxel make the difference?
No abstract availablehttp://ift.tt/2al82zX
Oncology
Adoption of new technology.
No abstract availablehttp://ift.tt/2al6pSRhttp://ift.tt/2akeuUN
Oncology
Review of perforator flaps in head and neck cancer surgery.
Purpose of review: Perforator flaps are increasingly being used to reconstruct head and neck defects. They offer several advantages over nonperforator-based flaps with lower donor site morbidity and a versatile range of reconstructive options. The anterolateral thigh flap is well established in the head...
Oncology
Early development and function of the Xenopus tadpole retinotectal circuit
Publication date: December 2016Source:Current Opinion in Neurobiology, Volume 41 Author(s): Zhenyu Liu, Ali S Hamodi, Kara G Pratt The retinotectal circuit is the major component of the amphibian visual system. It is comprised of the retinal ganglion cells (RGCs) in the eye, which project their axons...
Oncology
Meta-analysis Does Not Support Lower Complication Rates in Minimally Invasive Transforaminal Lumbar Interbody Fusion.
No abstract availablehttp://ift.tt/2aDxEL6http://ift.tt/2aDyaIW
Oncology
High-Risk Factors in Symptomatic Patients Undergoing Carotid Artery Stenting With Distal Protection: Buffalo Risk Assessment Scale (BRASS).
No abstract availablehttp://ift.tt/2aDy8kihttp://ift.tt/2aFucw2
Oncology
Lower Risk of Intracranial Arteriovenous Malformation Hemorrhage in Patients With Hereditary Hemorrhagic Telangiectasia.
No abstract availablehttp://ift.tt/2aFuDGWhttp://ift.tt/2aFudQG
Oncology
Imaging of Intracranial Pressure Disorders.
Intracranial pressure (ICP) is the pressure inside the bony calvarium and can be affected by a variety of processes, such as intracranial masses and edema, obstruction or leakage of cerebrospinal fluid, and obstruction of venous outflow. This review focuses on the imaging of 2 important but less well...
Oncology
Carotid Artery Angioplasty and Stenting Without Distal Embolic Protection Devices.
BACKGROUND: Embolic protection devices are used during carotid artery stenting procedures to reduce risk of distal embolization. Although this is a standard procedural recommendation, no studies have shown superiority of these devices over unprotected stenting procedures. OBJECTIVE: To assess the periprocedural...
Oncology
Repression of phosphoglycerate dehydrogenase sensitizes triple-negative breast cancer to doxorubicin
Abstract Purpose Approximately 70 % of triple-negative breast cancer (TNBC) cell lines are identified to upregulate phosphoglycerate dehydrogenase (PHGDH), which regulates the intracellular synthesis of serine and glycine, and promotes...
Oncology
In Reply: Meta-analysis Does Not Support Lower Complication Rates in Minimally Invasive Transforaminal Lumbar Interbody Fusion.
No abstract availablehttp://ift.tt/2aDxFi8http://ift.tt/2aFuqmX
Oncology
MassARRAY determination of somatic oncogenic mutations in solid tumors: moving forward to personalized medicine
Publication date: Available online 29 July 2016Source:Cancer Treatment Reviews Author(s): Tania Fleitas, Maider Ibarrola-Villava, Gloria Ribas, Andrés CervantesThis article will review the impact of the recently developed MassARRAY technology on our understanding of cancer biology and treatment....
Oncology
Reproductive factors and risk of developing breast cancer according to tumor subtype: a systematic review and meta-analysis of epidemiological studies
Publication date: Available online 29 July 2016Source:Cancer Treatment Reviews Author(s): Matteo Lambertini, Luigi Santoro, Lucia Del Mastro, Bastien Nguyen, Luca Livraghi, Donatella Ugolini, Fedro A. Peccatori, Hatem A. Azim JrBackgroundBreast cancer is composed of distinct subtypes...
Oncology
Repression of phosphoglycerate dehydrogenase sensitizes triple-negative breast cancer to doxorubicin
Abstract Purpose Approximately 70 % of triple-negative breast cancer (TNBC) cell lines are identified to upregulate phosphoglycerate dehydrogenase (PHGDH), which regulates the intracellular synthesis of serine and glycine, and promotes...
Oncology
ERBB2 overexpression creates Withaferin A hypersensitivity
Abstract. The catalytically deficient ERBB3 strongly synergizes with the receptor tyrosine kinase ERBB2, and elevated levels represent an overall risk factor for unfavorable disease outcomes in breast cancer. Although itself not a target of pan ERBB kinase inhibitors, it contributes to resistance in...
Oncology
Targeting homologous recombination in glioma chemotherapy
Malignant gliomas exhibit a high level of intrinsic and acquired drug resistance and have a dismal prognosis. First and second line therapeutics for glioblastomas are alkylating agents, including the chloroethylating nitrosoureas (CNUs) lomustine, nimustine, fotemustine and carmustine. These agents target...
Oncology
In vivo antitumor Activity of a Recombinant IL-7/IL-15
Both IL-7 and IL-15 have become important candidate immunomodulators for cancer treatment. However, IL-7 or IL-15 used alone suffers from shortcomings, such as short serum half-life and limited antitumor effect. We have cloned and expressed a recombinant ® IL-7/IL-15 fusion protein in which IL-7 and...
Oncology
Wedelolactone interrupts c-Myc oncogenic signaling
The c-Myc gene encodes an oncoprotein transcription factor which is frequently up-regulated in almost all cancer types, and is the subject of intense investigation for management of cancer because of its pleiotropic effects controlling a spectrum of cellular functions. However, due of its non-enzymatic...
Oncology
Imatinib changes collagen structure and increases transport
A typical obstacle to cancer therapy is the limited distribution of low-molecular weight anti-cancer drugs within the carcinoma tissue. In experimental carcinoma, Imatinib (STI571) increases efficacy of synchronized chemotherapy, reduces tumor interstitial fluid pressure and increases interstitial fluid...
Oncology
FLIP-mediated radio-resistance in NSCLC
Resistance to radiotherapy due to insufficient cancer cell death is a significant cause of treatment failure in non-small cell lung cancer (NSCLC). The endogenous caspase-8 inhibitor, FLIP, is a critical regulator of cell death that is frequently overexpressed in NSCLC and is an established inhibitor...
Oncology
Repression of phosphoglycerate dehydrogenase sensitizes triple-negative breast cancer to doxorubicin
Abstract Purpose Approximately 70 % of triple-negative breast cancer (TNBC) cell lines are identified to upregulate phosphoglycerate dehydrogenase (PHGDH), which regulates the intracellular synthesis of serine and glycine, and promotes...
Oncology
CNDAC drug combinations
CNDAC (2’-C-cyano-2’-deoxy-1-β-D-arabino-pentofuranosyl-cytosine, DFP10917) and its orally bioavailable prodrug, sapacitabine, are undergoing clinical trials for hematological malignancies and solid tumors. The unique action mechanism of inducing DNA strand breaks distinguishes CNDAC from other deoxycytidine...
Oncology
The 5th World Symposium for Lymphedema Surgery
from Cancer via xlomafota13 on Inoreader http://ift.tt/2akZZDf via IFTTThttp://ift.tt/2akb1oX
Oncology
In vivo antitumor Activity of a Recombinant IL-7/IL-15
Both IL-7 and IL-15 have become important candidate immunomodulators for cancer treatment. However, IL-7 or IL-15 used alone suffers from shortcomings, such as short serum half-life and limited antitumor effect. We have cloned and expressed a recombinant ® IL-7/IL-15 fusion protein in which IL-7 and...
Oncology
Targeting homologous recombination in glioma chemotherapy
Malignant gliomas exhibit a high level of intrinsic and acquired drug resistance and have a dismal prognosis. First and second line therapeutics for glioblastomas are alkylating agents, including the chloroethylating nitrosoureas (CNUs) lomustine, nimustine, fotemustine and carmustine. These agents target...
Oncology
In vivo antitumor Activity of a Recombinant IL-7/IL-15
Both IL-7 and IL-15 have become important candidate immunomodulators for cancer treatment. However, IL-7 or IL-15 used alone suffers from shortcomings, such as short serum half-life and limited antitumor effect. We have cloned and expressed a recombinant ® IL-7/IL-15 fusion protein in which IL-7 and...
Oncology
Imatinib changes collagen structure and increases transport
A typical obstacle to cancer therapy is the limited distribution of low-molecular weight anti-cancer drugs within the carcinoma tissue. In experimental carcinoma, Imatinib (STI571) increases efficacy of synchronized chemotherapy, reduces tumor interstitial fluid pressure and increases interstitial fluid...
Oncology
Wedelolactone interrupts c-Myc oncogenic signaling
The c-Myc gene encodes an oncoprotein transcription factor which is frequently up-regulated in almost all cancer types, and is the subject of intense investigation for management of cancer because of its pleiotropic effects controlling a spectrum of cellular functions. However, due of its non-enzymatic...
Oncology
FLIP-mediated radio-resistance in NSCLC
Resistance to radiotherapy due to insufficient cancer cell death is a significant cause of treatment failure in non-small cell lung cancer (NSCLC). The endogenous caspase-8 inhibitor, FLIP, is a critical regulator of cell death that is frequently overexpressed in NSCLC and is an established inhibitor...
Oncology
CNDAC drug combinations
CNDAC (2’-C-cyano-2’-deoxy-1-β-D-arabino-pentofuranosyl-cytosine, DFP10917) and its orally bioavailable prodrug, sapacitabine, are undergoing clinical trials for hematological malignancies and solid tumors. The unique action mechanism of inducing DNA strand breaks distinguishes CNDAC from other deoxycytidine...
Oncology
Repression of phosphoglycerate dehydrogenase sensitizes triple-negative breast cancer to doxorubicin
Abstract Purpose Approximately 70 % of triple-negative breast cancer (TNBC) cell lines are identified to upregulate phosphoglycerate dehydrogenase (PHGDH), which regulates the intracellular synthesis of serine and glycine, and promotes tumor growth. In this work, the impact of this pathway on doxorubicin...
Oncology
The 5th World Symposium for Lymphedema Surgery
from Cancer via ola Kala on Inoreader http://ift.tt/2akZZDf via IFTTThttp://ift.tt/2axS3hO
Oncology
The 5th World Symposium for Lymphedema Surgery
from Cancer via xlomafota13 on Inoreader http://ift.tt/2akZZDf via IFTTThttp://ift.tt/2a6DZ0B
Oncology
AKT-Independent SGK1 Signaling Confers Resistance to PI3K Inhibition [Research Watch: Drug Resistance]
SGK1 drives resistance to PI3Kα inhibitors in PI3KCA mutant breast cancer. from Cancer via xlomafota13 on Inoreader http://ift.tt/2anzJse via IFTTThttp://ift.tt/2a6DJhP
Oncology
CDK5 Promotes Tumor Immune Evasion via PD-L1 Upregulation [Research Watch: Medulloblastoma]
CDK5 suppression promotes CD4+ T cell–mediated antitumor immunity in medulloblastoma. from Cancer via xlomafota13 on Inoreader http://ift.tt/2ab8GgG via IFTTThttp://ift.tt/2aRcXHq
Oncology
PTIP Loss Protects BRCA-Deficient Cells from DNA Damage and Cell Death [Research Watch: DNA Repair]
Replication fork protection reduces chemosensitivity in BRCA-deficient cells without restoring HR. from Cancer via xlomafota13 on Inoreader http://ift.tt/2ab8zBE via IFTTThttp://ift.tt/2aRdoBI
Oncology
Ceritinib Exhibits Responses in Patients with ALK-Rearranged NSCLC [Research Watch: Clinical Trials]
Ceritinib produces durable responses in heavily pretreated patients who progressed on crizotinib. from Cancer via xlomafota13 on Inoreader http://ift.tt/2ab8ZYT via IFTTThttp://ift.tt/2aRd1H3
Oncology
DNMT3A and TET2 Cooperate and Compete to Maintain HSC DNA Methylation [Research Watch: Epigenetics]
Combined loss of DNMT3A and TET2 in HSCs promotes lineage-specific transcription factor expression. from Cancer via xlomafota13 on Inoreader http://ift.tt/2anAdPi via IFTTThttp://ift.tt/2a6E4kS
Oncology
ASTRO APEx® and RO-ILS™ are applicable to medical malpractice in radiation oncology
Future Oncology Ahead of Print. from Cancer via xlomafota13 on Inoreader http://ift.tt/2alJB3c via IFTTThttp://ift.tt/2a6DuU4
Oncology
Thyroid Ophthalmopathy, Dermopathy, and Acropachy.
Related ArticlesThyroid Ophthalmopathy, Dermopathy, and Acropachy. N Engl J Med. 2016 Jul 21;375(3):261 Authors: Guerrero C, Pittelkow MR Abstract A 56-year-old man was referred to a dermatologist for assessment of the progression of his thyroid...
Oncology
In vivo antitumor Activity of a Recombinant IL-7/IL-15
Both IL-7 and IL-15 have become important candidate immunomodulators for cancer treatment. However, IL-7 or IL-15 used alone suffers from shortcomings, such as short serum half-life and limited antitumor effect. We have cloned and expressed a recombinant ® IL-7/IL-15 fusion protein in which IL-7 and...
Oncology
ERBB2 overexpression creates Withaferin A hypersensitivity
Abstract. The catalytically deficient ERBB3 strongly synergizes with the receptor tyrosine kinase ERBB2, and elevated levels represent an overall risk factor for unfavorable disease outcomes in breast cancer. Although itself not a target of pan ERBB kinase inhibitors, it contributes to resistance in...
Oncology
Targeting homologous recombination in glioma chemotherapy
Malignant gliomas exhibit a high level of intrinsic and acquired drug resistance and have a dismal prognosis. First and second line therapeutics for glioblastomas are alkylating agents, including the chloroethylating nitrosoureas (CNUs) lomustine, nimustine, fotemustine and carmustine. These agents target...
Oncology
The 5th World Symposium for Lymphedema Surgery
http://ift.tt/2akZZDf
Oncology
Growth inhibitory effect of rapamycin in Hodgkin-lymphoma cell lines characterized by constitutive NOTCH1 activation
Abstract Growing evidence suggests that deregulation of signalling elements of Notch and mammalian target of rapamycin (mTOR) pathways contribute to tumorigenesis. These signals play important roles in cellular functions and malignancies. Their tumorigenic role in T-cell acute lymphoblastic leukaemia...
Oncology
Total and mutated EGFR quantification in cell-free DNA from non-small cell lung cancer patients detects tumor heterogeneity and presents prognostic value
Abstract Mutation analysis of epidermal growth factor receptor (EGFR) gene is essential for treatment selection in non-small cell lung cancer (NSCLC). Analysis is usually performed in tumor samples. We evaluated the clinical utility of EGFR analysis in plasma cell-free DNA (cfDNA) from patients under...
Oncology
Total and mutated EGFR quantification in cell-free DNA from non-small cell lung cancer patients detects tumor heterogeneity and presents prognostic value
Abstract Mutation analysis of epidermal growth factor receptor (EGFR) gene is essential for treatment selection in non-small cell lung cancer (NSCLC). Analysis is usually performed in tumor samples. We evaluated the clinical utility of EGFR analysis in plasma cell-free DNA (cfDNA)...
Oncology
Growth inhibitory effect of rapamycin in Hodgkin-lymphoma cell lines characterized by constitutive NOTCH1 activation
Abstract Growing evidence suggests that deregulation of signalling elements of Notch and mammalian target of rapamycin (mTOR) pathways contribute to tumorigenesis. These signals play important roles in cellular functions and malignancies. Their tumorigenic role in T-cell acute lymphoblastic...
Oncology
Computer-based tools for assessing micro-longitudinal patterns of cognitive function in older adults
Abstract Patterns of cognitive change over micro-longitudinal timescales (i.e., ranging from hours to days) are associated with a wide range of age-related health and functional outcomes. However, practical issues with conducting high-frequency assessments make investigations of micro-longitudinal cognition...
Oncology
ASTRO APEx® and RO-ILS™ are applicable to medical malpractice in radiation oncology
Future Oncology Ahead of Print. from Cancer via ola Kala on Inoreader http://ift.tt/2alJB3c via IFTTThttp://ift.tt/2a6BM4U
Oncology
ASTRO APEx® and RO-ILS™ are applicable to medical malpractice in radiation oncology
Future Oncology Ahead of Print. http://ift.tt/2alJB3c
Oncology
Computer-based tools for assessing micro-longitudinal patterns of cognitive function in older adults
Abstract Patterns of cognitive change over micro-longitudinal timescales (i.e., ranging from hours to days) are associated with a wide range of age-related health and functional outcomes. However, practical issues with conducting high-frequency assessments make investigations of micro-longitudinal...
Oncology
Early discharge as a mediator of greater ICU-level care requirements in patients not enrolled on the AAML0531 clinical trial: a Children's Oncology Group report
Abstract Previous data suggest that patients enrolled on clinical trials for treatment of cancer have better overall survival than patients who do not enroll; however, short-term outcomes relative to trial enrollment and corresponding mediators have not been assessed. A cohort of pediatric patients...
Oncology
Fine-Tuning Cancer Immunotherapy through the Gut Microbiome
The equilibrium linking the intestinal microbiota, the intestinal epithelium, and the host immune system establishes host health and homeostasis, with perturbations of this balance resulting in chronic inflammatory and autoimmune immunopathologies. The mutualistic symbiosis between gut microbiota and...
Oncology
Early discharge as a mediator of greater ICU-level care requirements in patients not enrolled on the AAML0531 clinical trial: a Children's Oncology Group report
Abstract Previous data suggest that patients enrolled on clinical trials for treatment of cancer have better overall survival than patients who do not enroll; however, short-term outcomes relative to trial enrollment and corresponding mediators have not been assessed. A cohort of pediatric patients...
Oncology
RE: "EVALUATION OF MODERATE ALCOHOL USE WITH QT INTERVAL AND HEART RATE USING MENDELIAN RANDOMIZATION ANALYSIS AMONG OLDER SOUTHERN CHINESE MEN IN THE GUANGZHOU BIOBANK COHORT STUDY"
from #Oncology via alexandrossfakianakis on Inoreader http://ift.tt/2ajbL41 via IFTTThttp://ift.tt/2alNZ2g
Oncology
Early discharge as a mediator of greater ICU-level care requirements in patients not enrolled on the AAML0531 clinical trial: a Children's Oncology Group report
Abstract Previous data suggest that patients enrolled on clinical trials for treatment of cancer have better overall survival than patients who do not enroll; however, short-term outcomes relative to trial enrollment and corresponding mediators have not been assessed. A cohort of pediatric patients...
Oncology
Fine-Tuning Cancer Immunotherapy through the Gut Microbiome
The equilibrium linking the intestinal microbiota, the intestinal epithelium, and the host immune system establishes host health and homeostasis, with perturbations of this balance resulting in chronic inflammatory and autoimmune immunopathologies. The mutualistic symbiosis between gut microbiota and...
Oncology
Fine-Tuning Cancer Immunotherapy through the Gut Microbiome
The equilibrium linking the intestinal microbiota, the intestinal epithelium, and the host immune system establishes host health and homeostasis, with perturbations of this balance resulting in chronic inflammatory and autoimmune immunopathologies. The mutualistic symbiosis between gut microbiota and...
Physiology by Alexandros G.Sfakianakis
Single-dose effects on the P3no-go ERP component predict clinical response to stimulants in pediatric ADHD
Attention-deficit hyperactivity disorder (ADHD) is a common developmental disorder involving problems with attention and/or hyperactivity and impulsivity. It is typically identified in childhood, with symptoms often persisting throughout adulthood (Faraone, et al. 2000). Comorbid disorders in behavior,...
Physiology by Alexandros G.Sfakianakis
Evidence of alterations in transcallosal motor inhibition as a possible long-term consequence of concussions in sports: a transcranial magnetic stimulation study
In the last two decades, concussions have been in the spotlight because of their high incidence in in youth sports such as football and ice hockey, accounting for 3-8% of all sport-related injuries presenting at the emergency (Pfister et al., 2016). Concussions are classified as mild traumatic brain...
Physiology by Alexandros G.Sfakianakis
Low-volume high-intensity swim training is superior to high-volume low-intensity training in relation to insulin sensitivity and glucose control in inactive middle-aged women
AbstractPurposeWe tested the hypothesis that low-volume high-intensity swimming has a larger impact on insulin sensitivity and glucose control than high-volume low-intensity swimming in inactive premenopausal women with mild hypertension.MethodsSixty-two untrained premenopausal women were randomised...
Physiology by Alexandros G.Sfakianakis
The impact of repetition mechanics on the adaptations resulting from strength-, hypertrophy- and cluster-type resistance training
AbstractPurposeThe purpose of this study was to examine the acute and chronic training responses to strength-, hypertrophy- and cluster-type resistance training.MethodsThirty-four trained males were assigned to a strength [STR: 4 × 6 repetitions, 85 % of one repetition maximum, (1RM), 900 s total rest],...
Physiology by Alexandros G.Sfakianakis
Does knee joint cooling change in vivo patellar tendon mechanical properties?
AbstractPurposeThis study aimed to assess the influence of knee joint cooling on the in vivo mechanical properties of the patellar tendon.MethodsTwenty young, healthy women volunteered for the study. B-mode ultrasonography was used to record patellar tendon elongation during isometric ramp contraction...
Rathiotherapy by Alexandros G. Sfakianakis
Non-coplanar trajectories to improve organ at risk sparing in volumetric modulated arc therapy for primary brain tumors
To evaluate non-coplanar volumetric modulated arc radiotherapy (VMAT) trajectories for organ at risk (OAR) sparing in primary brain tumor radiotherapy.from Rathiotherapy via xlomafota13 on Inoreader http://ift.tt/2awHLjp
Physiology by Alexandros G.Sfakianakis
Omega-3 fatty acids control productions of superoxide and nitrogen oxide and insulin content in INS-1E cells
AbstractOmega-3 fatty acids have multiple effects in peripheral tissues and pancreatic beta cell function. Dietary depletion of omega-3 fatty acids is associated with pancreatic islet dysfunction and insulin resistance in rats. Herein, the effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid...
Rathiotherapy by Alexandros G. Sfakianakis
Non-coplanar trajectories to improve organ at risk sparing in volumetric modulated arc therapy for primary brain tumors
Publication date: Available online 29 July 2016Source:Radiotherapy and OncologyAuthor(s): Gregory Smyth, Philip M. Evans, Jeffrey C. Bamber, Henry C. Mandeville, Liam C. Welsh, Frank H. Saran, James L. BedfordBackground and purposeTo evaluate non-coplanar volumetric modulated arc radiotherapy (VMAT)...
Occupational and Environmental Medicine by Alexandros G.Sfakianakis
Cross-shift study of exposure-response relationships between bioaerosol exposure and respiratory effects in the Norwegian grain and animal feed production industry
Objective We have studied cross-shift respiratory responses of several individual bioaerosol components of the dust in the grain and feed industry in Norway.Methods Cross-shift changes in lung function and nasal congestion, as well as in respiratory and systemic symptoms of 56 exposed workers and 36...
Oncology
Prognostic value of baseline seric Syndecan-1 in initially unresectable metastatic colorectal cancer patients: A simple biological score
Abstract In first-line metastatic colorectal cancer (mCRC), baseline prognostic factors allowing death risk and treatment strategy stratification are lacking. Syndecan-1 (CD138) soluble form was never described as a prognostic biomarker in mCRC. We investigated its additional prognostic value for overall...
Physiology by Alexandros G.Sfakianakis
Spatial orientation in patients with chronic unilateral vestibular hypofunction is ipsilesionally distorted
Innervation of the vestibular organs is provided by two branches of the vestibular nerve: the superior branch receives input from the horizontal and anterior semicircular canal (SCC) and the utriculus, the inferior branch contains axons from the posterior SCC and the sacculus (Gianoli et al., 2005; Curthoys,...
Oncology
Treatment of hemophilia: A qualitative study of mothers’ perspectives
Abstract BackgroundIn Norway, boys with hemophilia usually begin treatment after their first bleeding episode. Boys with severe hemophilia usually start prophylactic treatment around 18–24 months. Health professionals administer factor concentrate initially, but when boys are around 4 years old most...
Oncology
Atypical teratoid/rhabdoid tumor arising in a malignant glioma
Abstract Atypical teratoid/rhabdoid tumor (AT/RT), a highly malignant brain tumor in young children, usually arises de novo and has only rarely been described as a secondary malignancy. Here, we present a case of a child with glioblastoma, who was treated postoperatively by a combination of temozolomide,...
Oncology
Quality-assured cancer surgery for Wilms tumour: What is the role of the clinical trials groups?
http://ift.tt/2amffzY
Oncology
Preoperative systemic levels of VEGFA, IL-7, IL-17A, and TNF-β delineate two distinct groups of children with brain tumors
Abstract BackgroundPrimary brain tumors are the most common solid tumors in children. Increasing evidence demonstrates diverse intratumoral immune signatures, which are tentatively reflected in peripheral blood. ProcedureTwenty cytokines were analyzed in preoperative plasma samples from five healthy...
Oncology
Does socioeconomic status impact physical activity and sleep among children with cancer?
BackgroundCompared with healthy children, pediatric oncology patients have impaired sleep and engage in less physical activity (PA). Socioeconomic status (SES) may be one determinant of PA and sleep among pediatric oncology patients. ProcedureBetween November 12, 2009 and March 27, 2013, 50 pediatric...
Online Journals of Otolaryngology Head and Neck Surgery by Alexandros G.Sfakianakis
Cuatro líneas no bancarias para pymes
Cuatro líneas fuera del sistema bancario No computan en CIRBE y están completamente al margen de los bancos. Descúbrelas 1. Enisa Enisa es una empresa pública dependiente del Ministerio de Industria, Energía y Turismo. Su objetivo es promover proyectos empresariales viables e innovadores...
Oncology
Metastatic Ocular Melanoma to the Liver Exhibits Infiltrative and Nodular Growth Patterns
We examined liver specimens from 15 patients with uveal melanoma (UM) who had succumbed to their disseminated disease. We found two distinct growth patterns of UM metastasis: infiltrative (n=12) and nodular (n=3). In the infiltrative pattern, individual UM cells with a CD133+ cancer stem cell-like phenotype...
Oncology
Pregnancy complicated by haemorrhagic ascites in a woman with newly diagnosed HIV
A young pregnant Zambian woman was referred from a district hospital in South Zambia to the university teaching hospital, Lusaka with severe anaemia and ascites. The ascites had developed over a month and the woman was currently 15 weeks pregnant. Further workup revealed that the patient was HIV-positive...
Oncology
Calcific tendinitis of biceps femoris: an unusual site and cause for lateral knee pain
A 37-year-old man presented to the acute knee and sports medicine clinic with atraumatic lateral knee pain. He had point tenderness over the lateral aspect of his knee which had not settled with anti-inflammatory medications. Imaging revealed a large opaque lesion lateral to the knee and although there...
Oncology
Migration of peripherally inserted central catheter likely into the azygos vein: a conservative management
Description A 31-year-old female patient with systolic heart failure (ejection fraction of 30%) and automatic implantable cardioverter-defibrillator (AICD) was admitted to the hospital with sepsis from Staphylococcus hominis and Staphylococcus capitis bacteraemia. A transesophageal echocardiogram...
Oncology
Retraction
Retraction: “Response to dual blockade of epidermal growth factor receptor (EGFR) and cyclooxygenase-2 in nonsmall cell lung cancer may be dependent on the EGFR mutational status of the tumor” by Gadgeel SM, Ali S, Philip PA, Ahmed F, Wozniak A, Sarkar FH.The above article, published in Wiley Online...
Oncology
Retraction
Retraction: “Cisplatin-induced antitumor activity is potentiated by the soy isoflavonen genistein in BxPC-3 pancreatic tumor xenografts” by Mohammad RM, Banerjee S, Li Y, Aboukameel A, Kucuk O, Sarkar FH.The above article, published in Wiley Online Library (wileyonlinelibrary.com), has been retracted...
Oncology
Retraction
Retraction: “Notch-1 down-regulation by curcumin is associated with the inhibition of cell growth and the induction of apoptosis in pancreatic cancer cells” by Wang Z, Zhang Y, Banerjee S, Li Y, Sarkar FH.The above article, published in Wiley Online Library (wileyonlinelibrary.com), has been retracted...
Oncology
Retraction
Retraction: “Genistein enhances the effect of epidermal growth factor receptor tyrosine kinase inhibitors and inhibits nuclear factor kappa B in nonsmall cell lung cancer cell lines” by Gadgeel SM, Ali S, Philip PA, Wozniak A, Sarkar FH.The above article, published in Wiley Online Library (wileyonlinelibrary.com),...
Radiology by Alexandros G. Sfakianakis
Regression model analysis of the decreasing trend of cesium-137 concentration in the atmosphere since the Fukushima accident
Publication date: November 2016Source:Journal of Environmental Radioactivity, Volume 164Author(s): Kyo Kitayama, Kenji Ohse, Nagayoshi Shima, Kencho Kawatsu, Hirofumi TsukadaThe decreasing trend of the atmospheric 137Cs concentration in two cities in Fukushima prefecture was analyzed by a regression...
Oncology
"Anticancer Res"[jour]; +122 new citations
122 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: “Anticancer Res”[jour] These pubmed results were generated on 2016/07/29PubMed comprises more than 24 million citations for biomedical literature from MEDLINE,...
Oncology
Salt-Inducible Kinase 2 Couples Ovarian Cancer Cell Metabolism with Survival at the Adipocyte-Rich Metastatic Niche
Publication date: Available online 28 July 2016Source:Cancer Cell Author(s): Fabrizio Miranda, David Mannion, Shujuan Liu, Yiyan Zheng, Lingegowda S. Mangala, Clara Redondo, Sandra Herrero-Gonzalez, Ruoyan Xu, Charlotte Taylor, Donatien Fotso Chedom, Mohammad Karaminejadranjbar,...
Oncology
High-throughput Phenotyping of Lung Cancer Somatic Mutations
Publication date: Available online 28 July 2016Source:Cancer Cell Author(s): Alice H. Berger, Angela N. Brooks, Xiaoyun Wu, Yashaswi Shrestha, Candace Chouinard, Federica Piccioni, Mukta Bagul, Atanas Kamburov, Marcin Imielinski, Larson Hogstrom, Cong Zhu, Xiaoping Yang, Sasha...
Oncology
Dual Role of the Adaptive Immune System in Liver Injury and Hepatocellular Carcinoma Development
Publication date: Available online 28 July 2016Source:Cancer Cell Author(s): Jessica Endig, Laura Elisa Buitrago-Molina, Silke Marhenke, Florian Reisinger, Anna Saborowski, Jutta Schütt, Florian Limbourg, Christian Könecke, Alina Schreder, Alina Michael, Ana Clara Misslitz,...
Physiology by Alexandros G.Sfakianakis
Cross-modal distractors modulate oscillatory alpha power: the neural basis of impaired task performance
AbstractUnexpected novel sounds capture one's attention, even when irrelevant to the task pursued (e.g., playing video game). This often comes at a cost to the task (e.g., slower responding). The neural basis for this behavioral distraction effect is not well understood and is subject of this study....
Occupational and Environmental Medicine by Alexandros G.Sfakianakis
IJERPH, Vol. 13, Pages 768: Analysis of Consumption of Energy Drinks by a Group of Adolescent Athletes
Background: Energy drinks (EDs) have become widely popular among young adults and, even more so, among adolescents. Increasingly, they are consumed by athletes, particularly those who have just begun their sporting career. Uncontrolled and high consumption of EDs, in addition to other sources of caffeine,...
Occupational and Environmental Medicine by Alexandros G.Sfakianakis
IJERPH, Vol. 13, Pages 770: Prevalence and Risk Factors of Heart Failure with Preserved Ejection Fraction: A Population-Based Study in Northeast China
Background: Heart failure with preserved ejection fraction (HFpEF) has attracted increasing attention worldwide. We aimed to estimate the prevalence of HFpEF and analyze its correlates in a sample of residents of northeast China; Methods: A population-based study of 2230 participants ≥35 years old was...
Medicine by Sfakianakis G. Alexandros
OtoRhinoLaryngology & Medicine,New Articles,July 29th,2016,afternoon
15:52OtoRhinoLaryngology - Alexandros G. SfakianakisVascularized Lymph Node TransferA Review of the Current Evidence: Correction:15:50OtoRhinoLaryngology - Alexandros G. SfakianakisMandible Fracture Complications and Infection The Influence of Demographics and Modifiable Factors: Background: Mandible...

Δεν υπάρχουν σχόλια:

Δημοσίευση σχολίου

Σημείωση: Μόνο ένα μέλος αυτού του ιστολογίου μπορεί να αναρτήσει σχόλιο.