David J Browning,1 Chong Lee,1 Michael W Stewart,2 Maurice B Landers III3
1Charlotte Eye, Ear, Nose and Throat Associates, Charlotte, NC, 2Mayo Clinic, Jacksonville, FL, 3Kittner Eye Center, University of North Carolina, Chapel Hill, NC, USA
Purpose: To determine the effect of vitrectomy for center-involved diabetic macular edema (CI-DME).
Methods: This was a retrospective study of 53 eyes of 45 patients who had vitrectomy for CI-DME and were followed up for at least 12 months. Charts were reviewed for visual acuity (VA), central subfield mean thickness measured by optical coherence tomography, presurgical and postsurgical interventions for CI-DME, and number of office visits in the first 12 months after surgery. Preoperative spectral domain optical coherence tomography was performed on 38 patients, and they were graded for ellipsoid zone (EZ) intactness by three independent graders with assessment of agreement between graders using intraclass correlation coefficients and Bland–Altman analysis.
Results: The median VA improved from 20/100 (interquartile range [IQR], 20/63–20/200) at baseline to 20/63 (IQR, 20/32–20/125) at 12 months. The median central subfield mean thickness improved from 505 µm (IQR, 389–597 µm) at baseline to 279 µm (IQR, 246–339 µm) at 12 months. Intergrader agreement for EZ intactness was moderate (intraclass correlation coefficients 0.4294–0.6356). There was no relationship between preoperative intactness of the EZ and the 12-month change in VA.
Conclusion: Vitrectomy consistently thins the macula in CI-DME and, on average, leads to clinically significant improvement in VA comparable in size to that reported with serial intravitreal anti-vascular endothelial growth factor injections. A large, comparative, prospective, randomized clinical trial of these two treatments is needed to determine which is more effective and cost-effective.
Keywords: center-involved diabetic macular edema, diabetic macular edema, vitrectomy, spectral domain OCT
from #Medicine via ola Kala on Inoreader http://ift.tt/1NRMPbd
via IFTTT
Αρχειοθήκη ιστολογίου
-
►
2023
(138)
- ► Φεβρουαρίου (74)
- ► Ιανουαρίου (64)
-
►
2022
(849)
- ► Δεκεμβρίου (61)
- ► Σεπτεμβρίου (74)
- ► Φεβρουαρίου (65)
-
►
2021
(2936)
- ► Δεκεμβρίου (59)
- ► Σεπτεμβρίου (180)
- ► Φεβρουαρίου (325)
-
►
2020
(1624)
- ► Δεκεμβρίου (293)
- ► Σεπτεμβρίου (234)
- ► Φεβρουαρίου (28)
-
►
2019
(13362)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (5586)
- ► Ιανουαρίου (5696)
-
►
2018
(66471)
- ► Δεκεμβρίου (5242)
- ► Σεπτεμβρίου (5478)
- ► Φεβρουαρίου (4835)
- ► Ιανουαρίου (5592)
-
►
2017
(44259)
- ► Δεκεμβρίου (5110)
- ► Σεπτεμβρίου (5105)
-
▼
2016
(7467)
- ► Δεκεμβρίου (514)
- ► Σεπτεμβρίου (1038)
-
▼
Μαΐου
(630)
-
▼
Μαΐ 22
(46)
- Clinical utility of the KAMRA corneal inlay
- Time of maximum cycloplegia after instillation of ...
- Ranibizumab in monotherapy and combined with photo...
- Segmentation and removal of fibrovascular membrane...
- Neurofibromatosis: an update of ophthalmic charact...
- Tear volume estimation using a modified Schirmer t...
- Ocular manifestations of Sturge–Weber syndrome: pa...
- The IMPACT study: a prospective evaluation of the ...
- An exploratory study evaluating the effects of mac...
- Pre- and postsynaptic effects of brimonidine on is...
- Comparison of intraocular pressure adjusted by cen...
- Comparison of visual outcomes and subjective visua...
- A randomized, double-blind, placebo-controlled stu...
- Effect of benzalkonium chloride-free latanoprost o...
- A nonrandomized, open-label study to evaluate the ...
- Risk factors for visual impairment associated with...
- Pharmacokinetics and aqueous humor penetration of ...
- Outcomes of excimer laser enhancements in pseudoph...
- Feasibility study of sustained-release travoprost ...
- Vitrectomy for center-involved diabetic macular edema
- Glycan Node Analysis: A Bottom-up Approach to Glyc...
- Light-driven Enzymatic Decarboxylation
- Assessment of Startle Response and Its Prepulse In...
- Plasma miR-10a: A Potential Biomarker for Coronary...
- Two-Year Follow-Up after Contact Force Sensing Rad...
- The Utility of a Digital Virtual Template for Juni...
- A Review of Animal Models of Intervertebral Disc D...
- Volatiles from Subtropical Convolvulaceae That Int...
- Unveiling alterative splice diversity from human o...
- Proteomic characterization of Nα- and Nε-acetylati...
- A proteomic signature of ovarian cancer tumor flui...
- Transcriptomic and proteomic analyses provide new ...
- A cost-effective method to get insight into the pe...
- Screening for target toxins of the antiophidic pro...
- Oncogenic KIT mutations in different exons lead to...
- From great kivas to great houses: Community format...
- Antigenic characterization of influenza viruses pr...
- A national examination of pharmacy-based immunizat...
- Report of the Cent Gardes HIV Vaccines Conference....
- The impact of implementing a demand forecasting sy...
- Humoral, T-cell and B-cell immune responses to sea...
- Effectiveness of seasonal trivalent influenza vacc...
- Ultrastructural Changes and Death of Leishmania in...
- Responding to the existentials of non-life-threate...
- Home-applied IPL epilation may prevent the problem...
- General vulnerability to stuttering: The experienc...
-
▼
Μαΐ 22
(46)
- ► Φεβρουαρίου (793)
Αναζήτηση αυτού του ιστολογίου
Κυριακή 22 Μαΐου 2016
Vitrectomy for center-involved diabetic macular edema
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
-
Αλέξανδρος Γ. Σφακιανάκης Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,0030693260717...
-
heory of COVID-19 pathogenesis Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Yuichiro J. Suzuki ScienceD...
-
https://ift.tt/2MQ8Ai8
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου
Σημείωση: Μόνο ένα μέλος αυτού του ιστολογίου μπορεί να αναρτήσει σχόλιο.