Lower back pain is the leading cause of disability worldwide. Discogenic pain secondary to intervertebral disc degeneration is a significant cause of low back pain. Disc degeneration is a complex multifactorial process. Animal models are essential to furthering understanding of the degenerative process and testing potential therapies. The adult human lumbar intervertebral disc is characterized by the loss of notochordal cells, relatively large size, essentially avascular nature, and exposure to biomechanical stresses influenced by bipedalism. Animal models are compared with regard to the above characteristics. Numerous methods of inducing disc degeneration are reported. Broadly these can be considered under the categories of spontaneous degeneration, mechanical and structural models. The purpose of such animal models is to further our understanding and, ultimately, improve treatment of disc degeneration. The role of animal models of disc degeneration in translational research leading to clinical trials of novel cellular therapies is explored.
from #Medicine via ola Kala on Inoreader http://ift.tt/1TPcZNV
via IFTTT
Αρχειοθήκη ιστολογίου
-
►
2023
(138)
- ► Φεβρουαρίου (74)
- ► Ιανουαρίου (64)
-
►
2022
(849)
- ► Δεκεμβρίου (61)
- ► Σεπτεμβρίου (74)
- ► Φεβρουαρίου (65)
-
►
2021
(2936)
- ► Δεκεμβρίου (59)
- ► Σεπτεμβρίου (180)
- ► Φεβρουαρίου (325)
-
►
2020
(1624)
- ► Δεκεμβρίου (293)
- ► Σεπτεμβρίου (234)
- ► Φεβρουαρίου (28)
-
►
2019
(13362)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (5586)
- ► Ιανουαρίου (5696)
-
►
2018
(66471)
- ► Δεκεμβρίου (5242)
- ► Σεπτεμβρίου (5478)
- ► Φεβρουαρίου (4835)
- ► Ιανουαρίου (5592)
-
►
2017
(44259)
- ► Δεκεμβρίου (5110)
- ► Σεπτεμβρίου (5105)
-
▼
2016
(7467)
- ► Δεκεμβρίου (514)
- ► Σεπτεμβρίου (1038)
-
▼
Μαΐου
(630)
-
▼
Μαΐ 22
(46)
- Clinical utility of the KAMRA corneal inlay
- Time of maximum cycloplegia after instillation of ...
- Ranibizumab in monotherapy and combined with photo...
- Segmentation and removal of fibrovascular membrane...
- Neurofibromatosis: an update of ophthalmic charact...
- Tear volume estimation using a modified Schirmer t...
- Ocular manifestations of Sturge–Weber syndrome: pa...
- The IMPACT study: a prospective evaluation of the ...
- An exploratory study evaluating the effects of mac...
- Pre- and postsynaptic effects of brimonidine on is...
- Comparison of intraocular pressure adjusted by cen...
- Comparison of visual outcomes and subjective visua...
- A randomized, double-blind, placebo-controlled stu...
- Effect of benzalkonium chloride-free latanoprost o...
- A nonrandomized, open-label study to evaluate the ...
- Risk factors for visual impairment associated with...
- Pharmacokinetics and aqueous humor penetration of ...
- Outcomes of excimer laser enhancements in pseudoph...
- Feasibility study of sustained-release travoprost ...
- Vitrectomy for center-involved diabetic macular edema
- Glycan Node Analysis: A Bottom-up Approach to Glyc...
- Light-driven Enzymatic Decarboxylation
- Assessment of Startle Response and Its Prepulse In...
- Plasma miR-10a: A Potential Biomarker for Coronary...
- Two-Year Follow-Up after Contact Force Sensing Rad...
- The Utility of a Digital Virtual Template for Juni...
- A Review of Animal Models of Intervertebral Disc D...
- Volatiles from Subtropical Convolvulaceae That Int...
- Unveiling alterative splice diversity from human o...
- Proteomic characterization of Nα- and Nε-acetylati...
- A proteomic signature of ovarian cancer tumor flui...
- Transcriptomic and proteomic analyses provide new ...
- A cost-effective method to get insight into the pe...
- Screening for target toxins of the antiophidic pro...
- Oncogenic KIT mutations in different exons lead to...
- From great kivas to great houses: Community format...
- Antigenic characterization of influenza viruses pr...
- A national examination of pharmacy-based immunizat...
- Report of the Cent Gardes HIV Vaccines Conference....
- The impact of implementing a demand forecasting sy...
- Humoral, T-cell and B-cell immune responses to sea...
- Effectiveness of seasonal trivalent influenza vacc...
- Ultrastructural Changes and Death of Leishmania in...
- Responding to the existentials of non-life-threate...
- Home-applied IPL epilation may prevent the problem...
- General vulnerability to stuttering: The experienc...
-
▼
Μαΐ 22
(46)
- ► Φεβρουαρίου (793)
Αναζήτηση αυτού του ιστολογίου
Κυριακή 22 Μαΐου 2016
A Review of Animal Models of Intervertebral Disc Degeneration: Pathophysiology, Regeneration, and Translation to the Clinic
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
-
Αλέξανδρος Γ. Σφακιανάκης Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,0030693260717...
-
heory of COVID-19 pathogenesis Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Yuichiro J. Suzuki ScienceD...
-
Alimentary Pharmacology &Therapeutics, EarlyView. https://ift.tt/2qECBIJ
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου
Σημείωση: Μόνο ένα μέλος αυτού του ιστολογίου μπορεί να αναρτήσει σχόλιο.