Shamira A Perera,1–3 Daniel SW Ting,1,2 Monisha E Nongpiur,1–3 Paul T Chew,3 Maria Cecilia D Aquino,3 Chelvin CA Sng,3 Sue-Wei Ho,1,2 Tin Aung1–3
1Singapore Eye Research Institute, Singapore; 2Singapore National Eye Centre, Singapore; 3Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
Purpose: To investigate the efficacy and safety of a punctum plug-based sustained drug release system for a prostaglandin analog, travoprost (OTX-TP), for intraocular pressure (IOP) reduction in an Asian population.
Methods: This is an initial feasibility, prospective, single-arm study involving 26 eyes and a bioresorbable punctum plug containing OTX-TP. An OTX-TP was placed in the vertical portion of the superior or inferior canaliculus of patients with primary open-angle glaucoma or ocular hypertension. The main outcome measure was the IOP-lowering efficacy of OTX-TP at 3 (8 am) and 10, 20, and 30 days (8 am, 10 am, and 4 pm), compared to baseline.
Results: A total of 26 OTX-TP were inserted for 17 subjects. The mean (standard deviation) age was 57.2 (13.8) years. At 10 days, all plugs were still present, and the IOP reduction from baseline was 6.2 (23%), 5.4 (21%), and 7.5 mmHg (28%) at 8 am, 10 am, and 4 pm, respectively. At 10 days, the mean IOP (standard error of mean) was 21.2 (1.2), 20.4 (0.8), and 19.7 (1.0) at 8 am, 10 am, and 4 pm, respectively, showing no discernible IOP trend during the course of the day. At 30 days, plug retention had declined to 42%, and the overall IOP reduction had decreased to 16%.
Conclusion: The sustained-release OTX-TP is able to reduce IOP by 24% (day 10) and 15.6% (day 30), respectively. It is a potentially well-tolerable ocular hypotensive for glaucoma patients with a history of poor compliance.
Keywords: ocular hypertension, travoprost, bioresorbable, punctum plug, glaucoma, Asian
from #Medicine via ola Kala on Inoreader http://ift.tt/26t0nFw
via IFTTT
Αρχειοθήκη ιστολογίου
-
►
2023
(138)
- ► Φεβρουαρίου (74)
- ► Ιανουαρίου (64)
-
►
2022
(849)
- ► Δεκεμβρίου (61)
- ► Σεπτεμβρίου (74)
- ► Φεβρουαρίου (65)
-
►
2021
(2936)
- ► Δεκεμβρίου (59)
- ► Σεπτεμβρίου (180)
- ► Φεβρουαρίου (325)
-
►
2020
(1624)
- ► Δεκεμβρίου (293)
- ► Σεπτεμβρίου (234)
- ► Φεβρουαρίου (28)
-
►
2019
(13362)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (5586)
- ► Ιανουαρίου (5696)
-
►
2018
(66471)
- ► Δεκεμβρίου (5242)
- ► Σεπτεμβρίου (5478)
- ► Φεβρουαρίου (4835)
- ► Ιανουαρίου (5592)
-
►
2017
(44259)
- ► Δεκεμβρίου (5110)
- ► Σεπτεμβρίου (5105)
-
▼
2016
(7467)
- ► Δεκεμβρίου (514)
- ► Σεπτεμβρίου (1038)
-
▼
Μαΐου
(630)
-
▼
Μαΐ 22
(46)
- Clinical utility of the KAMRA corneal inlay
- Time of maximum cycloplegia after instillation of ...
- Ranibizumab in monotherapy and combined with photo...
- Segmentation and removal of fibrovascular membrane...
- Neurofibromatosis: an update of ophthalmic charact...
- Tear volume estimation using a modified Schirmer t...
- Ocular manifestations of Sturge–Weber syndrome: pa...
- The IMPACT study: a prospective evaluation of the ...
- An exploratory study evaluating the effects of mac...
- Pre- and postsynaptic effects of brimonidine on is...
- Comparison of intraocular pressure adjusted by cen...
- Comparison of visual outcomes and subjective visua...
- A randomized, double-blind, placebo-controlled stu...
- Effect of benzalkonium chloride-free latanoprost o...
- A nonrandomized, open-label study to evaluate the ...
- Risk factors for visual impairment associated with...
- Pharmacokinetics and aqueous humor penetration of ...
- Outcomes of excimer laser enhancements in pseudoph...
- Feasibility study of sustained-release travoprost ...
- Vitrectomy for center-involved diabetic macular edema
- Glycan Node Analysis: A Bottom-up Approach to Glyc...
- Light-driven Enzymatic Decarboxylation
- Assessment of Startle Response and Its Prepulse In...
- Plasma miR-10a: A Potential Biomarker for Coronary...
- Two-Year Follow-Up after Contact Force Sensing Rad...
- The Utility of a Digital Virtual Template for Juni...
- A Review of Animal Models of Intervertebral Disc D...
- Volatiles from Subtropical Convolvulaceae That Int...
- Unveiling alterative splice diversity from human o...
- Proteomic characterization of Nα- and Nε-acetylati...
- A proteomic signature of ovarian cancer tumor flui...
- Transcriptomic and proteomic analyses provide new ...
- A cost-effective method to get insight into the pe...
- Screening for target toxins of the antiophidic pro...
- Oncogenic KIT mutations in different exons lead to...
- From great kivas to great houses: Community format...
- Antigenic characterization of influenza viruses pr...
- A national examination of pharmacy-based immunizat...
- Report of the Cent Gardes HIV Vaccines Conference....
- The impact of implementing a demand forecasting sy...
- Humoral, T-cell and B-cell immune responses to sea...
- Effectiveness of seasonal trivalent influenza vacc...
- Ultrastructural Changes and Death of Leishmania in...
- Responding to the existentials of non-life-threate...
- Home-applied IPL epilation may prevent the problem...
- General vulnerability to stuttering: The experienc...
-
▼
Μαΐ 22
(46)
- ► Φεβρουαρίου (793)
Αναζήτηση αυτού του ιστολογίου
Κυριακή 22 Μαΐου 2016
Feasibility study of sustained-release travoprost punctum plug for intraocular pressure reduction in an Asian population
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
-
Αλέξανδρος Γ. Σφακιανάκης Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,0030693260717...
-
heory of COVID-19 pathogenesis Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Yuichiro J. Suzuki ScienceD...
-
https://ift.tt/2MQ8Ai8
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου
Σημείωση: Μόνο ένα μέλος αυτού του ιστολογίου μπορεί να αναρτήσει σχόλιο.