Publication date: December 2015
Source:Medical Hypotheses, Volume 85, Issue 6
Author(s): Jong Joo Kim, Rajani Rai
BackgroundChemo-resistance is the main obstacle in cancer therapy, limiting the effectiveness of drug treatment. Epigenetics-mediated changes are suggested as a critical factor paying the chemo-resistance phenotype. Since epigenetic modulations are a reversible phenomenon, reversion of epigenetic changes represents a promising therapeutic approach for cancer. However, heterogeneity in epigenetic marks in tumor cells makes it difficult to identify the specific epigenetic aberrations contributing to chemo-resistance. Our hypothesis aimed to explore this issue to add therapeutic options for cancer.Presentation of the hypothesisEpigenetic alterations, the main mediator of cellular reprogramming, occur rapidly upon exposure to chemotherapy. Recent studies have demonstrated that reprogramming resets/erases the epigenetic marks established during differentiation to specific somatic cell types. To overcome the heterogeneous nature of cancer cells, we will attempt to make homogenous cancer cell colonies by reprogramming. Comparison of the drug-resistant cancer cells obtained from these colonies to parent cancer cells and reprogrammed cancer cells is an effective way to determine the precise epigenetic alterations underlying specific chemo-resistance.Testing the hypothesisCellular reprogramming of cancer cells led to generation of homogenous colonies. Following lineage specification and long term drug treatment, the obtained drug resistance cells will be compared with parent cancer cells for whole genome epigenetic signature.Implications of the hypothesisA key implication of this hypothesis is that determination of the usefulness of cellular reprogramming of cancer cells enabling the identification of specific epigenetic modulation associated with particular drug resistance will enable exploration of new research avenues for cancer treatment.
from #Medicine via ola Kala on Inoreader http://ift.tt/1OPynCv
via IFTTT
Αρχειοθήκη ιστολογίου
-
►
2023
(138)
- ► Φεβρουαρίου (74)
- ► Ιανουαρίου (64)
-
►
2022
(849)
- ► Δεκεμβρίου (61)
- ► Σεπτεμβρίου (74)
- ► Φεβρουαρίου (65)
-
►
2021
(2936)
- ► Δεκεμβρίου (59)
- ► Σεπτεμβρίου (180)
- ► Φεβρουαρίου (325)
-
►
2020
(1624)
- ► Δεκεμβρίου (293)
- ► Σεπτεμβρίου (234)
- ► Φεβρουαρίου (28)
-
►
2019
(13362)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (5586)
- ► Ιανουαρίου (5696)
-
►
2018
(66471)
- ► Δεκεμβρίου (5242)
- ► Σεπτεμβρίου (5478)
- ► Φεβρουαρίου (4835)
- ► Ιανουαρίου (5592)
-
►
2017
(44259)
- ► Δεκεμβρίου (5110)
- ► Σεπτεμβρίου (5105)
-
►
2016
(7467)
- ► Δεκεμβρίου (514)
- ► Σεπτεμβρίου (1038)
- ► Φεβρουαρίου (793)
-
▼
2015
(2119)
-
▼
Δεκεμβρίου
(940)
-
▼
Δεκ 07
(50)
- Smart modification of the single conical nanochann...
- Bioluminescent bioreporter pad biosensor for monit...
- Exploring the Link between the Components of Metab...
- IJMS, Vol. 16, Pages 29148-29160: Primary Phenomen...
- Photonics, Vol. 2, Pages 1152-1163: InP-Based Wave...
- IJMS, Vol. 16, Pages 29120-29133: Phenolic Phytoal...
- IJMS, Vol. 16, Pages 29161-29178: Antioxidant and ...
- IJMS, Vol. 16, Pages 29134-29147: Allyl Isothiocya...
- IJMS, Vol. 16, Pages 29103-29119: Tumor-Associated...
- IJMS, Vol. 16, Pages 29179-29206: Bioinformatics M...
- Risks, Vol. 3, Pages 573-598: Information-Based Tr...
- Molecules, Vol. 20, Pages 21854-21869: Comparative...
- Molecules, Vol. 20, Pages 21840-21853: Alkylation ...
- Pharmaceutics, Vol. 7, Pages 542-553: Genomic Disc...
- Symmetry, Vol. 7, Pages 2195-2205: Estrada Index o...
- Sensors, Vol. 15, Pages 30810-30826: Calibration T...
- Technologies, Vol. 3, Pages 285-301: Effect of Ext...
- Sensors, Vol. 15, Pages 30827-30838: Maximum-Likel...
- Buildings, Vol. 5, Pages 1346-1360: The Use of Sou...
- Micromachines, Vol. 6, Pages 1914-1922: High Speed...
- Micromachines, Vol. 6, Pages 1923-1934: A Simple a...
- Gels, Vol. 1, Pages 235-255: Precise Control over ...
- Laws, Vol. 4, Pages 755-770: Embryonic Human Life ...
- Editorial Board/Aims and Scope
- A Brazilian report using serological and molecular...
- Emotion socialization practices in Italian and Hon...
- The Role of Toll-Like Receptors and Myeloid Differ...
- Protective effects of exercise in metabolic disord...
- Identification of the specific epigenetic alterati...
- “Cystic fibrotics could survive cholera, choleraic...
- A suggestion about the cause of inflammation in ac...
- A hypothesis about how to achieve anticoagulation ...
- Title page/Editorial Board
- Possible scenarios of the influence of low-dose io...
- Adiponutrin (PNPLA3) in liver fibrogenesis: Is una...
- Effect of protein arginine methyltransferase-1 inh...
- The transcription, translation, transport-trail an...
- Size of quadriceps femoris may contribute to thyro...
- Fatty acyl composition of lysophosphatidylcholine ...
- Possible role of granulysin in pathogenesis of ost...
- Baicalin may have a therapeutic effect in attentio...
- Myalgic encephalomyelitis, chronic fatigue syndrom...
- Mechanism of failure of the Cabrol procedure: A co...
- Review of Amyotrophic Lateral Sclerosis, Parkinson...
- Non-pharmacological treatment for neuropathic pain...
- On the origins of autism: The Quantitative Thresho...
- PET Radioligands Reveal the Basis of Dementia in P...
- IJERPH, Vol. 12, Pages 15516-15530: Adult Lifespan...
- IJERPH, Vol. 12, Pages 15531-15539: Association of...
- IJERPH, Vol. 12, Pages 15498-15515: A Systematic R...
-
▼
Δεκ 07
(50)
-
▼
Δεκεμβρίου
(940)
Αναζήτηση αυτού του ιστολογίου
Δευτέρα 7 Δεκεμβρίου 2015
Identification of the specific epigenetic alterations associated with chemo-resistance via reprogramming of cancer cells
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
-
Αλέξανδρος Γ. Σφακιανάκης Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,0030693260717...
-
heory of COVID-19 pathogenesis Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Yuichiro J. Suzuki ScienceD...
-
Alimentary Pharmacology &Therapeutics, EarlyView. https://ift.tt/2qECBIJ
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου
Σημείωση: Μόνο ένα μέλος αυτού του ιστολογίου μπορεί να αναρτήσει σχόλιο.