Publication date: December 2015
Source:Medical Hypotheses, Volume 85, Issue 6
Author(s): Chellan Kumarasamy, Gurpreet Singh, Pachaiappan Raman, Kanchana Mala
Hypoxia is defined as a decrease in the oxygen supply to a level below physiological levels which is insufficient to maintain cellular function, in the presence of unrestricted coronary inflow. It is one of the leading causes of global mortality and morbidity, due to its association with the pathology of cancer, cardiovascular disease and stroke. The common feature in these pathologies is the limitation of oxygen availability that participates in the development of these conditions. The pulmonary response to hypoxia, when hypoxia is localized, is hypoxic pulmonary vasoconstriction (HPV). HPV is a physiological and self-regulatory mechanism by which pulmonary capillary blood flow is automatically adjusted to alveolar ventilation for maintaining the optimal balance of ventilation and perfusion. In pathological conditions, HPV occurs as an acute episode during progressive critical illness or as a sustained response with vascular remodeling and pulmonary hypertension. Inspite of the hypoxia-induced shift in the redox status to a more oxidized state, the endothelium-dependent mediators of HPV that cause vasoconstrictor response to hypoxia include nitric oxide (NO), endothelin-1 and angiotensin-II. Indeed, in chronic hypoxia, due to the enhanced reactive oxygen species (ROS) generation, inhibition of endothelial nitric oxide synthase (eNOS) activity and reduced nitric oxide (NO) production there is an imbalance in the vasoconstriction–vasodilation status toward constriction. It is our hypothesis that, in hypoxic stress, a key player in initiating this imbalance is the enzyme, protein arginine methyltransferase-1 (PRMT1) which indirectly affects eNOS activity by increased production of asymmetric dimethylarginine (ADMA), a NOS-inhibitor. Thus, pharmacological inhibition of PRMT1 should restore the cellular and vascular homeostasis in hypoxic conditions.
from #Medicine via ola Kala on Inoreader http://ift.tt/1NQIHgv
via IFTTT
Αρχειοθήκη ιστολογίου
-
►
2023
(138)
- ► Φεβρουαρίου (74)
- ► Ιανουαρίου (64)
-
►
2022
(849)
- ► Δεκεμβρίου (61)
- ► Σεπτεμβρίου (74)
- ► Φεβρουαρίου (65)
-
►
2021
(2936)
- ► Δεκεμβρίου (59)
- ► Σεπτεμβρίου (180)
- ► Φεβρουαρίου (325)
-
►
2020
(1624)
- ► Δεκεμβρίου (293)
- ► Σεπτεμβρίου (234)
- ► Φεβρουαρίου (28)
-
►
2019
(13362)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (5586)
- ► Ιανουαρίου (5696)
-
►
2018
(66471)
- ► Δεκεμβρίου (5242)
- ► Σεπτεμβρίου (5478)
- ► Φεβρουαρίου (4835)
- ► Ιανουαρίου (5592)
-
►
2017
(44259)
- ► Δεκεμβρίου (5110)
- ► Σεπτεμβρίου (5105)
-
►
2016
(7467)
- ► Δεκεμβρίου (514)
- ► Σεπτεμβρίου (1038)
- ► Φεβρουαρίου (793)
-
▼
2015
(2119)
-
▼
Δεκεμβρίου
(940)
-
▼
Δεκ 07
(50)
- Smart modification of the single conical nanochann...
- Bioluminescent bioreporter pad biosensor for monit...
- Exploring the Link between the Components of Metab...
- IJMS, Vol. 16, Pages 29148-29160: Primary Phenomen...
- Photonics, Vol. 2, Pages 1152-1163: InP-Based Wave...
- IJMS, Vol. 16, Pages 29120-29133: Phenolic Phytoal...
- IJMS, Vol. 16, Pages 29161-29178: Antioxidant and ...
- IJMS, Vol. 16, Pages 29134-29147: Allyl Isothiocya...
- IJMS, Vol. 16, Pages 29103-29119: Tumor-Associated...
- IJMS, Vol. 16, Pages 29179-29206: Bioinformatics M...
- Risks, Vol. 3, Pages 573-598: Information-Based Tr...
- Molecules, Vol. 20, Pages 21854-21869: Comparative...
- Molecules, Vol. 20, Pages 21840-21853: Alkylation ...
- Pharmaceutics, Vol. 7, Pages 542-553: Genomic Disc...
- Symmetry, Vol. 7, Pages 2195-2205: Estrada Index o...
- Sensors, Vol. 15, Pages 30810-30826: Calibration T...
- Technologies, Vol. 3, Pages 285-301: Effect of Ext...
- Sensors, Vol. 15, Pages 30827-30838: Maximum-Likel...
- Buildings, Vol. 5, Pages 1346-1360: The Use of Sou...
- Micromachines, Vol. 6, Pages 1914-1922: High Speed...
- Micromachines, Vol. 6, Pages 1923-1934: A Simple a...
- Gels, Vol. 1, Pages 235-255: Precise Control over ...
- Laws, Vol. 4, Pages 755-770: Embryonic Human Life ...
- Editorial Board/Aims and Scope
- A Brazilian report using serological and molecular...
- Emotion socialization practices in Italian and Hon...
- The Role of Toll-Like Receptors and Myeloid Differ...
- Protective effects of exercise in metabolic disord...
- Identification of the specific epigenetic alterati...
- “Cystic fibrotics could survive cholera, choleraic...
- A suggestion about the cause of inflammation in ac...
- A hypothesis about how to achieve anticoagulation ...
- Title page/Editorial Board
- Possible scenarios of the influence of low-dose io...
- Adiponutrin (PNPLA3) in liver fibrogenesis: Is una...
- Effect of protein arginine methyltransferase-1 inh...
- The transcription, translation, transport-trail an...
- Size of quadriceps femoris may contribute to thyro...
- Fatty acyl composition of lysophosphatidylcholine ...
- Possible role of granulysin in pathogenesis of ost...
- Baicalin may have a therapeutic effect in attentio...
- Myalgic encephalomyelitis, chronic fatigue syndrom...
- Mechanism of failure of the Cabrol procedure: A co...
- Review of Amyotrophic Lateral Sclerosis, Parkinson...
- Non-pharmacological treatment for neuropathic pain...
- On the origins of autism: The Quantitative Thresho...
- PET Radioligands Reveal the Basis of Dementia in P...
- IJERPH, Vol. 12, Pages 15516-15530: Adult Lifespan...
- IJERPH, Vol. 12, Pages 15531-15539: Association of...
- IJERPH, Vol. 12, Pages 15498-15515: A Systematic R...
-
▼
Δεκ 07
(50)
-
▼
Δεκεμβρίου
(940)
Αναζήτηση αυτού του ιστολογίου
Δευτέρα 7 Δεκεμβρίου 2015
Effect of protein arginine methyltransferase-1 inhibition on hypoxia-induced vasoconstriction
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
-
Αλέξανδρος Γ. Σφακιανάκης Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,0030693260717...
-
heory of COVID-19 pathogenesis Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Yuichiro J. Suzuki ScienceD...
-
Alimentary Pharmacology &Therapeutics, EarlyView. https://ift.tt/2qECBIJ
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου
Σημείωση: Μόνο ένα μέλος αυτού του ιστολογίου μπορεί να αναρτήσει σχόλιο.