Publication date: December 2015
Source:Medical Hypotheses, Volume 85, Issue 6
Author(s): Arnold E. Eggers
The hypothesis is set forth that a prothrombotic state is frequently caused by epinephrine-activated platelets initiating the intrinsic coagulation cascade by binding factor XII, a pathway which is enhanced by stasis. This pathway explains spontaneous non-injury related thrombosis in atrial fibrillation on the arterial side of the circulation and deep vein thrombosis/pulmonary embolism on the venous side of the circulation. Pharmacological interventions directed against targets in this pathway, for example factor XII, the putative factor XII receptor on activated platelets, and the α2-adrenoceptor on platelets, would be expected to provide effective anticoagulation for most clinical indications for anticoagulation without incurring the bleeding risk associated with pharmacological blockade of the extrinsic pathway, which is the limiting factor for conventional anticoagulants. Thrombotic stroke is another possible indication for such a treatment.
from #Medicine via ola Kala on Inoreader http://ift.tt/1NQIHNv
via IFTTT
Αρχειοθήκη ιστολογίου
-
►
2023
(138)
- ► Φεβρουαρίου (74)
- ► Ιανουαρίου (64)
-
►
2022
(849)
- ► Δεκεμβρίου (61)
- ► Σεπτεμβρίου (74)
- ► Φεβρουαρίου (65)
-
►
2021
(2936)
- ► Δεκεμβρίου (59)
- ► Σεπτεμβρίου (180)
- ► Φεβρουαρίου (325)
-
►
2020
(1624)
- ► Δεκεμβρίου (293)
- ► Σεπτεμβρίου (234)
- ► Φεβρουαρίου (28)
-
►
2019
(13362)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (5586)
- ► Ιανουαρίου (5696)
-
►
2018
(66471)
- ► Δεκεμβρίου (5242)
- ► Σεπτεμβρίου (5478)
- ► Φεβρουαρίου (4835)
- ► Ιανουαρίου (5592)
-
►
2017
(44259)
- ► Δεκεμβρίου (5110)
- ► Σεπτεμβρίου (5105)
-
►
2016
(7467)
- ► Δεκεμβρίου (514)
- ► Σεπτεμβρίου (1038)
- ► Φεβρουαρίου (793)
-
▼
2015
(2119)
-
▼
Δεκεμβρίου
(940)
-
▼
Δεκ 07
(50)
- Smart modification of the single conical nanochann...
- Bioluminescent bioreporter pad biosensor for monit...
- Exploring the Link between the Components of Metab...
- IJMS, Vol. 16, Pages 29148-29160: Primary Phenomen...
- Photonics, Vol. 2, Pages 1152-1163: InP-Based Wave...
- IJMS, Vol. 16, Pages 29120-29133: Phenolic Phytoal...
- IJMS, Vol. 16, Pages 29161-29178: Antioxidant and ...
- IJMS, Vol. 16, Pages 29134-29147: Allyl Isothiocya...
- IJMS, Vol. 16, Pages 29103-29119: Tumor-Associated...
- IJMS, Vol. 16, Pages 29179-29206: Bioinformatics M...
- Risks, Vol. 3, Pages 573-598: Information-Based Tr...
- Molecules, Vol. 20, Pages 21854-21869: Comparative...
- Molecules, Vol. 20, Pages 21840-21853: Alkylation ...
- Pharmaceutics, Vol. 7, Pages 542-553: Genomic Disc...
- Symmetry, Vol. 7, Pages 2195-2205: Estrada Index o...
- Sensors, Vol. 15, Pages 30810-30826: Calibration T...
- Technologies, Vol. 3, Pages 285-301: Effect of Ext...
- Sensors, Vol. 15, Pages 30827-30838: Maximum-Likel...
- Buildings, Vol. 5, Pages 1346-1360: The Use of Sou...
- Micromachines, Vol. 6, Pages 1914-1922: High Speed...
- Micromachines, Vol. 6, Pages 1923-1934: A Simple a...
- Gels, Vol. 1, Pages 235-255: Precise Control over ...
- Laws, Vol. 4, Pages 755-770: Embryonic Human Life ...
- Editorial Board/Aims and Scope
- A Brazilian report using serological and molecular...
- Emotion socialization practices in Italian and Hon...
- The Role of Toll-Like Receptors and Myeloid Differ...
- Protective effects of exercise in metabolic disord...
- Identification of the specific epigenetic alterati...
- “Cystic fibrotics could survive cholera, choleraic...
- A suggestion about the cause of inflammation in ac...
- A hypothesis about how to achieve anticoagulation ...
- Title page/Editorial Board
- Possible scenarios of the influence of low-dose io...
- Adiponutrin (PNPLA3) in liver fibrogenesis: Is una...
- Effect of protein arginine methyltransferase-1 inh...
- The transcription, translation, transport-trail an...
- Size of quadriceps femoris may contribute to thyro...
- Fatty acyl composition of lysophosphatidylcholine ...
- Possible role of granulysin in pathogenesis of ost...
- Baicalin may have a therapeutic effect in attentio...
- Myalgic encephalomyelitis, chronic fatigue syndrom...
- Mechanism of failure of the Cabrol procedure: A co...
- Review of Amyotrophic Lateral Sclerosis, Parkinson...
- Non-pharmacological treatment for neuropathic pain...
- On the origins of autism: The Quantitative Thresho...
- PET Radioligands Reveal the Basis of Dementia in P...
- IJERPH, Vol. 12, Pages 15516-15530: Adult Lifespan...
- IJERPH, Vol. 12, Pages 15531-15539: Association of...
- IJERPH, Vol. 12, Pages 15498-15515: A Systematic R...
-
▼
Δεκ 07
(50)
-
▼
Δεκεμβρίου
(940)
Αναζήτηση αυτού του ιστολογίου
Δευτέρα 7 Δεκεμβρίου 2015
A hypothesis about how to achieve anticoagulation without bleeding
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
-
Αλέξανδρος Γ. Σφακιανάκης Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,0030693260717...
-
heory of COVID-19 pathogenesis Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Yuichiro J. Suzuki ScienceD...
-
Alimentary Pharmacology &Therapeutics, EarlyView. https://ift.tt/2qECBIJ
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου
Σημείωση: Μόνο ένα μέλος αυτού του ιστολογίου μπορεί να αναρτήσει σχόλιο.