Dengue Virus Immunity Increases Zika Virus-Induced Damage during Pregnancy

Dengue-specific antibodies can cross-react to Zika virus. Brown et al. demonstrate that dengue-specific antibodies can enhance Zika virus pathogenesis during pregnancy by increasing damage to the placenta. These findings suggest a possible mechanism for the recent increase in severe pregnancy outcomes after Zika virus infection in areas where dengue co-circulates.

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