Survival of Single Positive Thymocytes Depends upon Developmental Control of RIPK1 Kinase Signaling by the IKK Complex Independent of NF-κB

Survival of developing thymocytes depends upon activation of the IKK complex downstream of TNFR1 signaling by TNF. Webb and colleagues demonstrate that the pro-survival activity of IKK is mediated not by NF-κB activation but by direct repression of RIPK1 that otherwise triggers cell death in the absence of IKK activity.

http://bit.ly/2G8fuiU