The expressions and significance of APN, D-D, IL-17 and hs-CRP in patients with acute exacerbation of chronic obstructive pulmonary disease

OBJECTIVE: Inflammatory reactions and imbalance of oxidant/antioxidant and protease/anti-protease are the major causes of chronic obstructive pulmonary disease. Based on the information mentioned, the expressions and significance of adiponectin (APN), D-dimer (DD), Interleukin (IL)-17, and high-sensitivity CRP (hs-CRP) in patients with acute exacerbation of chronic obstructive pulmonary disease were investigated in this study.

PATIENTS AND METHODS: A total of 70 patients with chronic obstructive pulmonary disease were enrolled and divided into stable group (group A, 28 cases) and acute exacerbation group (group B, 42 cases). Thirty-five healthy volunteers were included in the control group (group C, 35 cases). The levels of serum APN, IL- 17, D-D, and hs-CRP were tested and compared

RESULTS: Levels of APN from Group B were significantly lower than that of Group A or Group C, while levels of APN of Group A were also significantly lower than that of Group C, (p < 0.05). Levels of IL-17, D-D, and Hs-CRP of group b were significantly increased compared to that of Group A or Group C, and levels of IL-17, D-D, and Hs-CRP of Group A were significantly elevated compared to that of Group C (p < 0.05). A negative statistical correlation was found between APN and IL-17, D-D, and Hs-CRP (p < 0.05).

CONCLUSIONS: Levels of APN were downregulated in patients with acute exacerbation of chronic obstructive pulmonary disease. The expression levels of APN, IL-17, D-D, and Hs-CRP were closely correlated with clinical stages and can be used as parameters for the evaluation of the severity of chronic obstructive pulmonary disease.

L'articolo The expressions and significance of APN, D-D, IL-17 and hs-CRP in patients with acute exacerbation of chronic obstructive pulmonary disease sembra essere il primo su European Review.

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