Interleukin-6 signaling blockade exacerbates acute and late injury from focal intestinal irradiation

The time-dependent immune response to focal intestinal irradiation has not been investigated. Therefore, we used immunofluorescence to quantify changes in leukocyte populations after focal irradiation. Subsequently, we investigated the role of interleukin-6 signaling using knockout mice and antibody mediated signaling blockade. We identified time-dependent fluctuations in leukocyte populations in the irradiated intestine and further noted interleukin-6 signaling blockade exacerbates intestinal radiation injury.

https://ift.tt/2pTFFQn