Learning About “Known Unknowns” and “Unknown Unknowns” to Cure HIV

An allogeneic hematopoietic stem cell transplant (allo-HSCT) cured Timothy Ray Brown of HIV and cancer, adding more "known unknowns" to the HIV cure research agenda. How are latent HIV reservoirs so radically depleted by allo-HSCT? In this issue, Salgado and colleagues report on the largest number of HIV-infected patients receiving allo-HSCT with CCR5 wild-type donor cells for hematologic disease who have been studied to date and begin to address this question. The editorialist discusses the implications of the findings.

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