p53-loss mitigates early volume deficits in the brains of irradiated young mice

In the brain, radiation-induced apoptosis is largely mediated by p53. We used longitudinal magnetic resonance imaging in a mouse model to map radiation-induced changes in neuroanatomy and quantified the impact of knocking out p53. We observed mitigation of radiation-induced volume loss by p53-knockout one week after treatment, but this was not maintained to adulthood due to decreased growth.

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