What Is the Diagnostic Accuracy of Cardiac Biomarkers for the Prediction of Adverse Cardiac Events in Patients Presenting With Acute Syncope?

The initial search identified 1,595 articles, and 104 met the inclusion criteria and underwent a full test review. Eleven studies met the inclusion criteria for analysis and were included in the review. Four of the included studies used contemporary troponins, 4 used brain-type natriuretic peptides, and 3 used high-sensitivity troponins. The majority of included studies (9) enrolled emergency department (ED) patients, but 2 included hospitalized patients who were admitted from the ED. According to the Quality Assessment of Diagnostic Accuracy Studies instrument, the included studies were at low to moderate risk of bias.

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