An Atomistic Model of a Precursor State of Light-Induced Channel Opening of Channelrhodopsin

Channelrhodopsins (ChRs) are microbial light-gated ion channels with a retinal chromophore, and are widely utilized in optogenetics to precisely control neuronal activity with light. Despite increasing understanding of their structures and photo-activation kinetics, the atomistic mechanism of light gating and ion conduction remains elusive. Here, we present an atomic structural model of a chimeric ChR in a precursor state of the channel opening determined by an accurate hybrid molecular simulation technique and a statistical theory of internal water distribution.

https://ift.tt/2MBOwnB