Chronic lymphocytic leukemia with proliferation centers in bone marrow is associated with younger age at initial presentation, complex karyotype and TP53 disruption

The presence of expanded proliferation centers (PCs) in lymph nodes involved by chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) has been associated with adverse clinical outcomes, but the frequency and significance of PCs in bone marrow (BM) remains unclear. The study group included 36 patients with BM involvement by CLL in which PCs were present. We compared this group with 110 randomly selected BM samples involved by CLL without morphologically discernable PCs. Patients with PCs in BM were younger (median age, 53years [range,18–71] versus 58years [range, 31–82]; P=.007), more frequently experienced B-symptoms (27.8% versus 8.2%, P=.0076), more often had Rai stage IV disease (30.6% versus 17.3, P=.020), higher serum lactate dehydrogenase (P=.0037) and beta-2- microglobulin (P=.0001) levels, and lower median hemoglobin (P=.026) and platelet counts (P=.0422).

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